Abstract：【Objective】 To investigate the effects of intrarenal capsule injection of hydrocortisone sodium succinate on oxidative stress and renal function in patients with nephrotic syndrome(NS). 【Methods】 A total of 116 patients with NS were randomly divided into the observation group (hydrocortisone sodium succinate + oral glucocorticoid therapy,58 cases) and the control group (oral glucocorticoid therapy alone,58 cases). To compare the treatment effect between the two groups,glutathione transferase (GSH),superoxide dismutase (SOD),malondialdehyde (MDA),urea nitrogen (BUN),creatinine (Scr) and 24 h urinary protein were measured and compared between the two groups before and after treatment. The incidence of insomnia,elevated blood sugar,digestive tract reaction,obesity and other adverse reactions were compared between the two groups during treatment as well. 【Results】 The total effective rate of the observation group was 89.66%,which was significantly higher than that of the control group (74.14%) (P<0.05). Levels of both GSH and SOD after treatment were significantly higher than those before treatment,while MDA level was significantly lower than before treatment (P<0.05),Levels of GSH and SOD after treatment in the observation group were significantly higher than those after treatment in the control group,while MDA level was significantly lower than that in the control group (P<0.05). After treatment,BUN,Scr and 24 h urinary protein of the two groups were significantly lower than those before treatment (P<0.05),and levels of BUN,Scr and 24 h urinary protein of the observation group after treatment was significantly lower than those of the control group after treatment (P<0.05). The total incidence of adverse reactions in the observation group was 13.79%,which was no significant difference compared with 6.90% in the control group (P>0.05). 【Conclusion】 Intracapsular administration of hydrocortisone sodium succinate improves oxidative stress and renal function in patients with nephrotic syndrome.
孙琪, 王燕. 肾囊内注射氢化可的松琥珀酸钠对肾病综合征患者氧化应激及肾功能的影响[J]. 医学临床研究, 2023, 40(3): 389-391.
SUN Qi, WANG Yan. Effects of Intrarenal Capsule Injection of Hydrocortisone Sodium Succinate on Oxidative Stress and Renal Function in Patients with Nephrotic Syndrome. JOURNAL OF CLINICAL RESEARCH, 2023, 40(3): 389-391.
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2023, Vol. 40 
