医学临床研究
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医学临床研究  2022, Vol. 39 Issue (9): 1385-1388    DOI: 10.3969/j.issn.1671-7171.2022.09.029
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不同剂量卡托普利治疗成人病毒感染性心肌炎的疗效
陈永国, 王冬红, 尚江
商洛市商南县医院心血管内科,陕西 商洛 726300
Efficacy of Captopril with different doses in Treatment of Adult Viral Myocarditis
CHEN Yong-guo, WANG Dong-hong, SHANG Jiang
Department of Cardiovascular Medicine,Shangluo Shangnan County Hospital,Shangluo Shaanxi 726300
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摘要 【目的】探讨不同剂量卡托普利治疗成人病毒感染性心肌炎的疗效。【方法】本院收治的106例成人病毒感染性心肌炎患者,在常规治疗基础上加用卡托普利,根据用药剂量不同分为小剂量组(n=50,剂量为25 mg)和大剂量组(n=56,剂量为50 mg)。比较两组临床疗效和治疗前后血清肌钙蛋白T(cTnT)、血清肌钙蛋白I(cTnI)、心肌酶谱[α-羟丁酸脱氢酶(α-HBDH)、乳酸脱氢酶(LDH)、肌酸激酶同工酶(CK-MB)、天门冬酸氨基转移酶(AST)]水平;对比两组治疗前后心功能[左心室射血分数(LVEF)、心脏每搏输出量(SV)、心室短轴缩短率(FS)]指标变化和不良反应发生率。【结果】大剂量组总有效率高于小剂量组(P<0.05)。两组治疗后cTnT、cTnI水平较治疗前降低(P<0.05);大剂量组治疗后cTnT水平低于小剂量组(P<0.05),cTnI水平与小剂量组比较,差异无统计学意义(P>0.05)。两组治疗后α-HBDH、LDH、CK-MB、AST水平较治疗前降低(P<0.05);大剂量组治疗后α-HBDH、LDH、CK-MB、AST水平低于小剂量组(P<0.05)。两组治疗后LVEF、SV、FS水平较治疗前升高(P<0.05);大剂量组治疗后LVEF、SV、FS水平高于小剂量组(P<0.05)。大剂量组不良反应发生率高于小剂量组(P<0.05)。【结论】相较于小剂量用药,大剂量卡托普利治疗成人病毒感染性心肌炎患者疗效显著,但可增加患者不良反应发生的风险。
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陈永国
王冬红
尚江
关键词 心肌炎病毒性疾病卡托普利/治疗应用治疗结果    
Abstract:【Objective】To explore the efficacy of Captopril with different doses in the treatment of adult viral myocarditis.【Methods】A total of 106 patients with viral myocarditis treated in our hospital were divided into the low-dose group (n= 50,25 mg) and the high-dose group (n= 56,50 mg) according to different doses of captopril on the basis of conventional treatment.The clinical efficacy and the levels of serum troponin T (cTnT),serum troponin I (cTnI),myocardial enzyme profile [α-hydroxybutyrate dehydrogenase (α-HBDH),lactate dehydrogenase (LDH),creatine kinase isoenzyme (CK-MB),aspartic aminotransferase (AST)] before and after treatment were compared between the two groups.The changes of cardiac function [left ventricular ejection fraction (LVEF),cardiac output per stroke (SV),ventricular short axis shortening rate (FS)] and the incidence of adverse reactions were compared between the two groups before and after treatment as well.【Results】The total effective rate in the high-dose captopril group was higher than that in the low-dose group (P<0.05).The levels of cTnT and cTnI in both groups were lower after treatment than before (P<0.05).The cTnT level in the high-dose group was lower than that in the low-dose group (P<0.05),while there was no significant difference in the cTnI level between the high-dose group and the low-dose group (P>0.05).After treatment,the levels of α-HBDH,LDH,CK-MB and AST in both groups were decreased compared to those before treatment (P<0.05).After treatment,the levels of α-HBDH,LDH,CK-MB and AST in the high-dose group were lower than those in the low-dose group (P<0.05).After treatment,the levels of LVEF,SV and FS in both groups were higher than those before treatment (P<0.05).The levels of LVEF,SV and FS in the high-dose group were higher than those in the low-dose group (P<0.05).The incidence of adverse reactions in the high-dose group was higher than that in the low-dose group (P<0.05).【Conclusion】Compared to captopril low-dose medication,high-dose captopril is more effective in the treatment of adult viral myocarditis,however,it increases the risk of adverse reactions.
Key wordsMyocarditis    Virus Diseases    Captopril/TU    Treatment Outcome
收稿日期: 2022-04-07     
中图分类号:  R542.211  
引用本文:   
陈永国, 王冬红, 尚江. 不同剂量卡托普利治疗成人病毒感染性心肌炎的疗效[J]. 医学临床研究, 2022, 39(9): 1385-1388.
CHEN Yong-guo, WANG Dong-hong, SHANG Jiang. Efficacy of Captopril with different doses in Treatment of Adult Viral Myocarditis. JOURNAL OF CLINICAL RESEARCH, 2022, 39(9): 1385-1388.
链接本文:  
http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2022.09.029     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2022/V39/I9/1385
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