Abstract：【Objective】 To observe the changes and significance of serum neurospecific enolase (NSE) and neurofilament protein-3 (NFP-3) levels in patients with acute ischemic stroke (AIS). 【Methods】 A total of 65 patients with AIS were selected as the observation group, and another 40 healthy people in the same period were selected as the control group. Peripheral blood samples were collected in the observation group within 24 hours and on D3, D7 and D14, and peripheral blood samples were collected in the control group on the day of admission for detection of NSE and NFP-3 levels, and the differences between the two groups at different time points were compared; ROC curve was drawn to analyze the diagnostic value of NSE and NFP and their combination in patients with AIS.【Results】 The levels of NSE and NFP-3 in the observation group were significantly higher than those in the control group within 24 hours, 3 and 7 days after admission (P<0.05); there was no significant difference between the two groups on 14 days after admission (P>0.05); the levels of NSE and NFP-3 in the observation group increased first and then decreased with the change of admission time. The AUC of NSE, nfp-3 and their combination in predicting AIS were 0.874, 0.926 and 0.967, respectively. The sensitivity was 72.3%, 76.9% and 85.2%, and the specificity was 90.3%, 92.5% and 95.6%, respectively. The best cut-off values of NSE and NFP-3 were 17.25ng/mL and 15.55ng/mL, respectively.【Conclusion】 Serum NSE and NFP-3 levels in AIS patients were significantly increased, and with the improvement of the disease, their levels showed a downward trend. NSE and NFP-3 have higher diagnostic value for AIS, and the diagnostic value of nfp-3 is higher than that of NSE. The combination of NSE and nfp-3 can significantly improve the diagnostic value of AIS, suggesting that NFP-3 can be used for the diagnosis and assessment of AIS.
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2021, Vol. 38 
