2型糖尿病患者血清尿酸水平与心血管事件发生的相关性分析

doi:10.3969/j.issn.1671-7171.2021.10.011

摘要
图/表
参考文献
相关文章 (15)

全文: PDF (1160 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要【目的】探讨2型糖尿病(T2DM)患者血清尿酸(SUA)水平与心血管事件发生的相关性。【方法】选取2017年1月至2018年12月在本院诊治的132例T2DM患者(T2DM组),根据是否发生心血管事件分为发生心血管疾病组(n=43)和未发生心血管疾病组(n=89),另外选取同期在本院体检的健康志愿者138例(对照组)。比较三组SUA水平, Logistic多因素回归分析T2DM患者SUA水平与心血管事件发生的相关性。【结果】T2DM组患者血清SUA水平显著高于对照组,其差异有统计学意义(P<0.05);T2DM患者心血管疾病发生率32.58%(43/132),高于对照组的15.94%(22/138),其差异有统计学意义(χ²=10.21,P=0.00)。发生心血管疾病组与未发生心血管疾病组患者性别、年龄、糖尿病病程、体重指数(BMI)、SUA、C反应蛋白(CRP)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、三酰甘油(TG)及舒张压(DBP)指标比较,差异均无统计学意义(P>0.05);发生心血管疾病组患者的SUA、糖化血红蛋白(HbA1c)水平及收缩压(SBP)显著高于未发生心血管疾病组(P<0.05);多因素Logistic回归分析结果显示:SUA、HbA1c水平及DBP是T2DM患者心血管疾病发生的独立危险因素。【结论】高SUA水平是T2DM患者心血管疾病发生的危险因素。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章

关键词 ：糖尿病,2型/并发症, 尿酸/血液, 心血管疾病, 危险因素

Abstract：【Objective】To explore the relationship between serum uric acid (SUA) levels and the risk of cardiovascular events in patients with type 2 diabetes (T2DM). 【Methods】A total of 132 patients with type 2 diabetes who were admitted to our hospital from January 2017 to December 2018 were selected. According to whether a cardiovascular event occurred, patients were divided into the cardiovascular disease group (43 cases) and the non-cardiovascular disease group (89 cases).During the same period, 138 healthy people on physical examination were selected as the control group. SUA levels among groups were compared, and the correlation between the levels of SUA in T2DM patients and the occurrence of cardiovascular events was analyzed by Logistic multivariate analysis. 【Results】The level of SUA in the T2DM group was higher than that in the control group (P<0.05).The incidence of cardiovascular disease in T2DM patients was 32.58% (43/132), which was higher than 15.94% (22/132) in the control group (χ²=10.212,P=0.001).There were no significant differences in gender, age, course of diabetes, BMI, C-reactive protein (CRP), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), serum total cholesterol (TC), triglycerides (TG) and diastolic blood pressure (DBP) between the cardiovascular disease group and the non-occurring group (P>0.05).The levels of SUA, HbA1c and SBP in the cardiovascular disease group were higher than those in the non-cardiovascular disease group (P<0.05). The results of multivariate logistic regression analysis show that SUA, HbA1c and systolic blood pressure were independent risk factors for cardiovascular disease. 【Conclusion】SUA level is related to the risk of cardiovascular disease in 2T2DM patients.

Key words： Diabetes Mellitus, Type 2/CO Uric Acid/BL Cardiovascular Diseases Risk Factors

收稿日期: 2019-02-26

中图分类号:

R587.1

基金资助:陕西省重点研发计划项目(编号:2021SF-353)

通讯作者: **E-mail:yanfyy@163.com

引用本文:

闫凤, 常焕, 吕岩, 张红霞, 常明则, 张薇, 史丽娜. 2型糖尿病患者血清尿酸水平与心血管事件发生的相关性分析[J]. 医学临床研究, 2021, 38(10): 1480-1482.
YAN Feng, CHANG Huan, LYU Yan, et al. Study on the Relationship between Serum Uric Acid Level and the Risk of Cardiovascular Events in Patients with Type 2 Diabetes. JOURNAL OF CLINICAL RESEARCH, 2021, 38(10): 1480-1482.

链接本文:

http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2021.10.011 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2021/V38/I10/1480