Abstract：【Objective】To investigate expression and significance of tumor necrosis factor-alpha inducible protein-8-like molecule-2 (TIPE-2), p65 mRNA, tumor necrosis factor-α(TNF-α ) and interleukin-6 (IL-6) in peripheral blood of patients with rheumatoid arthritis (RA).【Methods】According to the disease activity score 28 (DAS28), 147 RA patients from our hospital from December 2015 to December 2018 were divided into RA remission group (DAS28≤3.2 score, n=65) and RA active group (DAS28＞3.2, n=82), while 45 healthy volunteers were selected as the control group. the levels of TIPE-2, p65 protein, TNF-α and IL-6 were detected and compared among the three groups. The relationship of TIPE-2 with p65 mRNA, TNF-α and IL-6 in peripheral blood of RA patients was analyzed by Sperman correlation analysis. 【Results】The levels of TIPE-2, DAS28, p65 mRNA, TNF-α and IL-6 in peripheral blood of RA group were higher than those of control group (P<0.05).P. Those indicators of RA active group were higher than those of RA remission group and control group; and the difference was statistically significant (P<0.05).Pearson correlation analysis showed that there was a positive correlation of TIPE-2 with DAS28 score, p65 mRNA, TNF-α and IL-6 in peripheral blood of RA patients, with r values of 0.322, 0.620, 0.705 and 0.632,respectively (P<0.001). 【Conclusion】The levels of TIPE-2, DAS28 score, p65 mRNA, TNF-α and IL-6 in peripheral blood of RA patients increased, where the level of TIPE-2 was positively correlated with DAS28 score, p65 mRNA, TNF-α and IL-6, which can provide certain value for the progress and prognosis evaluation of RA.
汪学耀, 荆成宝, 王婵. 类风湿关节炎患者外周血TIPE-2表达水平及其临床意义[J]. 医学临床研究, 2020, 37(11): 1650-1653.
WANG Xue-yao, JING Cheng-bao, WANG Chan. Expression and Significance of TIPE-2 in Peripheral Blood of Patients with Rheumatoid Arthritis. JOURNAL OF CLINICAL RESEARCH, 2020, 37(11): 1650-1653.
2020, Vol. 37 
