医学临床研究
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医学临床研究  2020, Vol. 37 Issue (1): 86-88    DOI: 10.3969/j.issn.1671-7171.2020.01.027
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血清NT-proBNP、Cys-C水平评估对老年慢性心衰患者合并急性肾损伤的预后价值
刘英华, 高晓丽, 张小坤, 谢明, 刘亚宁, 崔慎情
河北省任丘市华北石油管理局总医院,河北 任丘 062550
Prognostic Value of Serum NT-proBNP and Cys-C Levels in Elderly Patients with Chronic Heart Failure Complicated with Acute Renal Injury
LIU Ying-hua, GAO Xiao-li, ZHANG Xiao-kun,et al
Huabei Petroleum General Hospital,renqiu 062550
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摘要 【目的】 分析血清氨基末端B型脑钠肽前体(NT-proBNP)、胱抑素C(Cys-C)水平对老年慢性心衰(CHF)患者合并急性肾损伤(AKI)的预后价值。【方法】 回顾性分析2016年7月至2018年3月本院收治的年龄≥60岁的104例CHF合并AKI患者的临床资料,根据患者随访6个月的预后情况将其分为预后良好组(n=73)和预后不良组(n=31)。收集并比较不同心功能分级患者血清NT-proBNP、Cys-C水平的差异,并分析NT-proBNP、Cys-C水平对患者预后的影响。【结果】 预后不良组患者入院时血清NT-proBNP、Cys-C水平显著高于预后良好组,差异有统计学意义(P<0.05)。NYHA Ⅳ级患者血清NT-proBNP、Cys-C水平显著高于NYHA Ⅱ级、Ⅲ级患者,NYHA Ⅲ级患者血清NT-proBNP、Cys-C水平显著高于NYHA Ⅱ级,差异均有统计学意义(P<0.05)。死亡亚组患者血清NT-proBNP、Cys-C水平显著高于非死亡亚组,差异均有统计学意义(P<0.05)。血清NT-proBNP、Cys-C水平均为CHF合并AKI患者预后不良的危险因素(ORNT-proBNP=1.34,ORCys-C=1.49,均P<0.05)。NT-proBNP、Cys-C及两者联合应用预测CHF合并AKI患者预后ROC曲线下面积分别为0.676、0.749、0.842。【结论】 检测血清NT-proBNP、Cys-C水平可较好的预测老年CHF合并AKI患者预后,两者联合检测预测价值更高。
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关键词 心力衰竭/并发症慢性病肾/损伤利钠肽,脑/血液    
Abstract【Objective】To analyze the prognostic value of serum NT proBNP and Cys-C levels in elderly patients with chronic heart failure (CHF) combimed with acute renal injury (AKI).【Methods】 The clinical data of 104 patients with CHF and AKI aged ≥ 60 years in our hospital from July 2016 to March 2018 were analyzed retrospectively. According to the prognosis of patients who were followed up for 6 months, they were divided into good prognosis group (n=73) and bad prognosis group (n=31) The difference of serum NT proBNP and Cys-C levels in patients with different functional grades, and the influence of NT-proBNP and Cys-C levels on the prognosis of patients were collected and compared.【Results】 The levels of NT proBNP and Cys-C in patients with poor prognosis at admission were significantly higher than those in patients with good prognosis (P<0.05).The levels of NT-proBNP and Cys-C in patients with NYHA Ⅳ were significantly higher than those of patients with NYHA Ⅱ and Ⅲ, and the levels of NT -proBNP and Cys-C in patients with NYHA Ⅲ were significantly higher than those of patients with NYHA Ⅱ (P<0.05).The levels of NT proBNP and Cys-C in the dead subgroup were significantly higher than those in the non dead subgroup (P<0.05). The serum levels of NT-proBNP and Cys-C were the risk factors of poor prognosis in CHF patients with AKI (ORNT-proBNP=1.34,ORCys-C=1.49,all P<0.05); NT-proBNP, Cys-C and their combination predict the area under ROC curve of CHF patients with AKI was 0.676, 0.749 and 0.842, respectively.【Conclusion】Detection of serum NT-proBNP and Cys-C levels can better predict the prognosis of elderly patients with CHF with AKI, and the combined detection of them has a higher predictive value.
Key wordsHeart failure/CO    Chronic Disease    Kidney/IN    Natriuretic Peptide,Brain/BL
收稿日期: 2019-05-05     
PACS:  R541.61  
引用本文:   
刘英华, 高晓丽, 张小坤, 谢明, 刘亚宁, 崔慎情. 血清NT-proBNP、Cys-C水平评估对老年慢性心衰患者合并急性肾损伤的预后价值[J]. 医学临床研究, 2020, 37(1): 86-88.
LIU Ying-hua, GAO Xiao-li, ZHANG Xiao-kun,et al. Prognostic Value of Serum NT-proBNP and Cys-C Levels in Elderly Patients with Chronic Heart Failure Complicated with Acute Renal Injury. JOURNAL OF CLINICAL RESEARCH, 2020, 37(1): 86-88.
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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2020.01.027     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2020/V37/I1/86
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