Abstract：【Objective】To investigate the effect of multi-modal analgesia on primary hepatocellular carcinoma (PHC) treated with hepatic arterial chemoembolization (TACE). 【Methods】A total of 68 cases of PHC patients received TACE treatment were randomly divided into two groups, with 34 cases in each group. The control group used traditional analgesia and the observation group used multimodal analgesia. Visual pain simulation score (VAS) was used to assess the degree of pain in the patient at 1 h before surgery, at the time of administration, immediately after surgery (T0), 2 h after surgery (T2), 4 h (T4), 6 h (T6), 12 h (T12), 24 h (T24) and 48 h (T48) after surgery. The levels of IL-6 and S100β protein were detected and compared at 1 day before surgery and d1,d3 after operation. The adverse reactions within 48 hours after surgery were recorded in both groups. 【Results】The VAS scores of the T0, T2, T4, T6, T12, and T24 in the observation group were significantly lower than those in the control group (P<0.05). There was no significant difference in the VAS scores of the two groups at T48 after surgery (P>0.05). There was no significant difference in the levels of serum IL-6 and S100β between the two groups at 1 day before operation (P>0.05). The levels of serum IL-6 and S100β in the observation group were significantly lower than those in the control group at 1d and 3d after operation (P<0.05). The incidence of total adverse reactions in two group was no significant difference (P>0.05). 【Conclusion】The use of multimodal analgesia in TACE can help reduce postoperative pain in PHC patients and reduce the level of inflammatory response without increasing adverse reactions.
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2019, Vol. 36 
