Abstract：【Objective】To investigate the effect of microwave ablation on serum levels of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) in patients with advanced non-small cell lung cancer (NSCLC).【Methods】A total of 57 patients with advanced non-small cell lung cancer were randomly divided into two groups:30 cases in the observation group who received microwave ablation therapy, and 27 cases in the control group who did not receive microwave ablation treatment. Blood was drawn on the day of treatment and two weeks after treatment. Serum levels of VEGF and MMP-9 were measured by enzyme-linked immunosorbent assay (ELISA). Meanwhile, complications associated with the treatment were evaluated.【Results】Serum levels of MMP-9 and VEGF were not significantly different between the two groups before treatment (P＞0.05). After treatment, serum VEGF levels in both groups showed a decreasing trend, but the difference was not statistically significant (P＞0.05). However, after treatment, the serum MMP-9 levels of two groups were significantly lower than those before treatment (P<0.05), and the decrease in the observation group was greater than that in the control group (P<0.05). No serious adverse reactions occurred in the observation group.【Conclusion】Microwave ablation therapy can significantly reduce the serum level of MMP-9 levels in patients with advanced non-small cell lung cancer. It provides the therapeutic evidence for the application of local hyperthermia in advanced peripheral lung cancer.
亓久德,任刚,王继松,牟坤,施明亮. 微波消融治疗对进展期NSCLL患者血清MMP-9和VEGF的影响[J]. 医学临床研究, 2018, 35(2): 266-267,270.
QI Jiu-de, REN Gang, WANG Ji-song, et al. Influence of Microwave Ablation Therapy on Serum Levels of VEGF and MMP-9 in Patients with Advanced Non-small Cell Lung Cancer. JOURNAL OF CLINICAL RESEARCH, 2018, 35(2): 266-267,270.
2018, Vol. 35 
