医学临床研究
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医学临床研究  2019, Vol. 36 Issue (9): 1671-1673    DOI: 10.3969/j.issn.1671-7171.2019.09.003
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GDF-15 miRNA在宫颈癌患者血清中的表达及其意义
黄江梅1a, 肖芳1a, 赵敏1a**, 陈艳昕1a, 王慧芳1b, 孙红2
1. 秦皇岛市第一医院:a. 病理科; b. 妇科,河北 秦皇岛 066000;
2. 华北理工大学附属医院病理科, 河北 唐山 063015
Expression and Significance of GDF-15 microRNAs in Serum of Patients with Cervical Cancer
HUANG Jiang-mei, XIAO Fang, ZHAO Min, et al
Department of Pathology,Qinhuangdao First Hospital, Qinhuangdao Hebei 066000
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摘要 目的】探讨生长分化因子15(GDF-15) miRNA在宫颈癌患者血清中的表达及其意义。【方法】选择2012年5月至2016年3月在本院诊治的64例宫颈癌患者(宫颈癌组)和54例宫颈上皮内瘤变(CIN)患者(CIN组),另外选取同期在本院体检健康者46例作为对照组。采用RT-PCR法检测三组受试者血清GDF-15 miRNA表达量,并分析GDF-15 miRNA表达量与宫颈癌患者临床病理及预后的关系。【结果】宫颈癌组患者血清GDF-15 miRNA表达量为(3.12±1.11),高于CIN组的1.97±0.53和健康对照组的1.07±0.37;宫颈癌患者血清GDF-15 miRNA表达与年龄、病理类型和肿瘤大小无关(P>0.05),与FIGO分期、淋巴结转移和分化程度有关(P<0.05)。对64例宫颈癌患者进行3年跟踪随访,45例(70.31%)幸存,19例(9.69%)死亡,平均生存时间(29.39±1.36)个月;GDF-15 miRNA>3.12宫颈癌患者总生存时间为(25.87±2.27)个月,明显少于GDF-15 miRNA≤3.12的(32.50±1.39)个月,其差异均有统计学意义(P<0.05)。【结论】宫颈癌患者血清GDF-15 miRNA表达量升高,并与患者FIGO分期、淋巴结转移和分化程度有关;对GDF-15进行监测有助于宫颈癌患者预后评估。
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关键词 宫颈肿瘤/病理生理学    
Abstract:【Objective】 To investigate the expression and significance of growth differentiation factor 15 (GDF-15) miRNA in serum of patients with cervical cancer.【Methods】 Sixty-four patients with cervical cancer (cervical cancer group) and 54 patients with cervical intraepithelial neoplasia (CIN) (CIN group) were enrolled in our hospital from May 2012 to March 2016. Forty-six healthy subjects in the hospital were used as a control group.The expression of GDF-15 miRNA in serum of three groups was detected by RT-PCR, and the relationship between GDF-15 miRNA expression and clinical pathology and prognosis of cervical cancer patients was analyzed.【Results】 The expression of serum GDF-15 miRNA in cervical cancer patients was (3.12±1.11), which was higher than 1.97±0.53 in the CIN group and 1.07±0.37 in the healthy control group.The expression of serum GDF-15 miRNA in cervical cancer patients was not correlated with age, pathological type and tumor size (P>0.05), and was associated with FIGO stage, lymph node metastasis and differentiation (P<0.05).Sixty-four patients with cervical cancer were followed up for 3 years. 45 patients (70.31%) survived, 19 patients (9.69%) died, and the average survival time was (29.39±1.36) months.The total survival time of patients with GDF-15 miRNA>3.12 cervical cancer was 25.87(±2.27) months, which was significantly less than that of GDF-15 miRNA≤3.12 (32.50±1.39 months) , the difference was statistically significant (P<0.05). 【Conclusion】 The expression of serum GDF-15 microRNAs increases in cervical cancer patients, which is related to FIGO staging, lymph node metastasis and differentiation. Monitoring GDF-15 is helpful to evaluate the prognosis of cervical cancer patients.
Key wordsUterine Cervical Neoplasms/PP
收稿日期: 2018-11-06     
PACS:  R711.74  
基金资助:秦皇岛市科技计划项目(201602A199)
通讯作者: E-mail:496437510@qq.com   
引用本文:   
黄江梅, 肖芳, 赵敏, 陈艳昕, 王慧芳, 孙红. GDF-15 miRNA在宫颈癌患者血清中的表达及其意义[J]. 医学临床研究, 2019, 36(9): 1671-1673.
HUANG Jiang-mei, XIAO Fang, ZHAO Min, et al. Expression and Significance of GDF-15 microRNAs in Serum of Patients with Cervical Cancer. JOURNAL OF CLINICAL RESEARCH, 2019, 36(9): 1671-1673.
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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2019.09.003     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2019/V36/I9/1671
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