医学临床研究
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医学临床研究  2019, Vol. 36 Issue (6): 1041-1043    DOI: 10.3969/j.issn.1671-7171.2019.06.001
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CD147、FOXM1在宫颈癌中的表达及其意义
吴湘1, 吴菲1, 阳丽1, 曾伟奇2, 申竑3, 罗军1
1.湖南省妇幼保健院妇科,湖南 长沙 410008;
2.中南大学湘雅医院皮肤病学、皮肤癌与银屑病人体重点实验室,湖南 长沙 410013;
3.中南大学湘雅医院中心实验室,湖南 长沙 410013
Expression and Significance Of CD147 and FOXM1 in Cervical Cancer
WU Xiang, WU Fei, YANG Li,et al
Department of Gynecology, Hunan Provincial Maternal and Child Health Care Hospital, Changsha 410008, Hunan, China
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摘要 【目的】探讨宫颈癌组织细胞外基质金属蛋白酶诱导因子(CD147)、叉头框转录因子M1(FOXM1)蛋白的表达及意义。【方法】应用免疫组织化学染色SP法检测31例宫颈癌及35例对照组CD147和FOXM1的表达情况。【结果】宫颈癌中CD147、FOXM1的阳性表达率均明显高于对照组; 且CD147、FOXM1的阳性表达与FIGO 2018宫颈癌分期呈正相关(P<0.01)。【结论】CD147和FOXM1在宫颈癌的浸润和转移方面起重要作用,联合检测CD147 和FOXM1有望成为判断宫颈癌预后的新指标。
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Abstract【Objective】To investigate the expression and significance of CD147 and FOXM1 in cervical cancer. 【Methods】SP immunohistochemical staining was used to detect the expression of CD147 and FOXM1 in 31 cases of cervical cancer and 35 cases in the control group.【Results】The results showed that the positive rates of CD147 and FOXM1 in the cervical cancer group were significantly higher than those in control group,and the positive expression of CD147 and FOXM1 was closely related to the stage of FIGO 2018 cervical cancer; moreover, in cervical cancer, expression of CD147 was positively related with FOXM1(P<0.01). 【Conclusions】CD147 and FOXM1 played an important role in invasion and metastasis of cervical cancer. Joint detection of CD147 and FOXM1 was expected to be new index for judging the prognosis of cervical cancer.
收稿日期: 2019-05-28     
PACS:  R711.74  
基金资助:湖南省卫生计生委科研课题(B2016066)
引用本文:   
吴湘, 吴菲, 阳丽, 曾伟奇, 申竑, 罗军. CD147、FOXM1在宫颈癌中的表达及其意义[J]. 医学临床研究, 2019, 36(6): 1041-1043.
WU Xiang, WU Fei, YANG Li,et al. Expression and Significance Of CD147 and FOXM1 in Cervical Cancer. JOURNAL OF CLINICAL RESEARCH, 2019, 36(6): 1041-1043.
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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2019.06.001     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2019/V36/I6/1041
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