Abstract：【Objective】 To investigate the expression and significance of growth differentiation factor 15 (GDF-15) miRNA in serum of patients with cervical cancer.【Methods】 Sixty-four patients with cervical cancer (cervical cancer group) and 54 patients with cervical intraepithelial neoplasia (CIN) (CIN group) were enrolled in our hospital from May 2012 to March 2016. Forty-six healthy subjects in the hospital were used as a control group.The expression of GDF-15 miRNA in serum of three groups was detected by RT-PCR, and the relationship between GDF-15 miRNA expression and clinical pathology and prognosis of cervical cancer patients was analyzed.【Results】 The expression of serum GDF-15 miRNA in cervical cancer patients was (3.12±1.11), which was higher than 1.97±0.53 in the CIN group and 1.07±0.37 in the healthy control group.The expression of serum GDF-15 miRNA in cervical cancer patients was not correlated with age, pathological type and tumor size (P>0.05), and was associated with FIGO stage, lymph node metastasis and differentiation (P<0.05).Sixty-four patients with cervical cancer were followed up for 3 years. 45 patients (70.31%) survived, 19 patients (9.69%) died, and the average survival time was (29.39±1.36) months.The total survival time of patients with GDF-15 miRNA>3.12 cervical cancer was 25.87(±2.27) months, which was significantly less than that of GDF-15 miRNA≤3.12 (32.50±1.39 months) , the difference was statistically significant (P<0.05). 【Conclusion】 The expression of serum GDF-15 microRNAs increases in cervical cancer patients, which is related to FIGO staging, lymph node metastasis and differentiation. Monitoring GDF-15 is helpful to evaluate the prognosis of cervical cancer patients.
2019, Vol. 36 
