[1] Fowkes FGR,Rudan D,Rudan I,et al. Comparison of global estimates of prevalence and risk factors for peripheral artery disease in 2000 and 2010: a systematic review and analysis[J].Lancet,2013, 382(9901):1329-1340. [2] Bockhorn J, Dalton R, Nwachukwu C, et al. MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11[J].Nature Communications,2017, 4(1):1393. [3] Huang S, Chen Z, Wu W, et al. MicroRNA-31 promotes arterial smooth muscle cell proliferation and migration by targeting mitofusin-2 in arteriosclerosis obliterans of the lower extremitie[J].Exp Ther Med,2018, 15(1):633-640. [4] He XM, Zheng YQ, Liu SZ,et al. Altered Plasma MicroRNAs as Novel Biomarkers for Arteriosclerosis Obliterans[J].J Atheroscler Thromb,2016,23(2):196-206. [5] Fodor J, Gomba-Tóth A, Oláh T, et al. Alteration of sarcoplasmic reticulum Ca(2+) ATPase expression in lower limb ischemia caused by atherosclerosis obliterans[J].Physiol Int,2017, 104(2):102-104. [6] Wang M , Li W , Chang G Q , et al. MicroRNA-21 regulates vascular smooth muscle cell function via targeting tropomyosin 1 in arteriosclerosis obliterans of lower extremitie[J].Arteriosc Thromb Vasc Biol,2011, 31(9):2044. [7] Wang Z, Zhao Z, Yang Y, et al. MiR-99b-5p and miR-203a-3p Function as Tumor Suppressors by Targeting IGF-1R in Gastric Cancer[J].Sci Rep,2018, 8(1):10119. [8] Huang SC,Wang M,Wu WB, et al. Mir-22-3p Inhibits Arterial Smooth Muscle Cell Proliferation and Migration and Neointimal Hyperplasia by Targeting HMGB1 in Arteriosclerosis Obliterans[J].Cell Physiol Biochem,2017:2492-2506. [9] Schlosser K, White RJ, Stewart DJ.miR-26a Linked to Pulmonary Hypertension by Global Assessment of Circulating Extracellular MicroRNAs[J].Am J Respir Crit Care Med,2013, 188(12):1472-1475. [10] Lacolley P,Regnault V,Nicoletti A,et al. The vascular smooth muscle cell in arterial pathology: a cell that can take on multiple roles[J].Cardiovasc Res,2012, 95(2):194-204.