Abstract:【Objective】 To analyze the factors influencing the mortality of patients with lower limbs arteriosclerosis obliterans (ASO). 【Methods】 The clinical data of 235 patients with ASO from January 2011 to June 2015 from our hospital were retrospectively collected. According to followup results, patients were divided into two groups i.e. survival and death . Methods of treatment,classification of ischemia, hematology indices, and complications which may affect the prognosis were analyzed. 【Results】 Only 186 patients out of the original 235 patients completed their followup; 58 patients died and the mortality rate was 31%. In the death group, the percentages of aging (more than 70 years old), critical limb ischemia (CLI),heart disease, cerebrovascular disease, chronic renal insufficiency, anemia, hypoalbuminemia, conservative treatment were higher than those of the survival group (significant differences with p<0.05). Further statistical results showed that CLI, hypoalbuminemia, heart disease, and conservative therapy method were independent risk factors of the mortality of ASO patients. 【Conclusion】 CLI, hypoalbuminemia, heart disease, and conservative therapy were independent risk factors of the mortality of ASO patients. Therefore it is very important to deal with these indicators properly in patients with ASO.