Abstract:【Objective】To explore the diagnostic value of bedside lung ultrasound in neonatal pulmonary hyaline membrane disease (HMD). 【Methods】A total of 90 neonatal patients with lung hyaline membrane disease admitted to our hospital from May 2017 to December 2018 were selected as research objects. They were divided into the control group and the observation group by random number table method, with 45 cases in each group. The control group was given bedside computer radiography (CR) for HMD diagnosis, while the observation group was given bedside lung ultrasound (US). Taking the neonatal digital imaging (DR) examination as the gold diagnostic standard, the HMD diagnostic methods of CR and US were compared. Furthermore, bedside lung ultrasound was evaluated to assess the severity of the disease. 【Results】There were no significant differences in the sensitivity and positive predictive value between the observation group (US) and the control group (CR) (P>0.05), while the specificity and negative predictive value of US were significantly higher than those of CR (P<0.05). The total pulmonary ultrasound score of severe HMD children was significantly higher than that of mild HMD children, however, PaO2/FiO2 of the severe group was significantly lower than that of the mild group. The differences were statistically significant (P<0.05). Pearson correlation analysis results showed that there was a negative correlation between pulmonary ultrasound assessment of HMD and PaO2/FiO2 (r=-1.655,P<0.05). 【Conclusion】Bedside lung ultrasound has the advantages of non-invasive and repeatable in the diagnosis of neonatal pulmonary hyaline membrane disease. Its high diagnostic efficiency also reflects the severity of the disease which is worthy of clinical promotion.