TgAb与TRAb联合检测对甲状腺癌的诊断价值

doi:10.3969/j.issn.1671-7171.2025.07.008

摘要
图/表
参考文献
相关文章 (15)

全文: PDF (1234 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要【目的】探讨甲状腺球蛋白抗体(TgAb)与促甲状腺素受体抗体(TRAb)联合检测对甲状腺癌的诊断价值。【方法】85例甲状腺癌患者设为观察组,92例甲状腺良性病变患者设为对照组。比较两组患者的基本资料和影像学检查结果及血清甲状腺球蛋白(TG)、促甲状腺激素(TSH)、TgAb、TRAb水平。采用Logistic回归分析发生甲状腺癌的风险因素,采用受试者工作特征(ROC)曲线评估TgAb、TRAb联合检测对甲状腺癌的诊断价值。【结果】观察组影像学结果中肿瘤形态不规则、纵横比≥1、存在微小钙化、边界模糊且极低回声的占比及收缩期峰值流速(PSV)、阻力系数(RI)高于对照组(P<0.05);观察组TG、TSH、TgAb、TRAb水平均高于对照组(P<0.05)。Logistic回归分析显示,患者的影像学检测指标、TG、TSH、TgAb、TRAb水平均是发生甲状腺癌的风险因素(P<0.05)。ROC曲线显示,TgAb、TRAb联合检测诊断甲状腺癌的准确度为0.926。【结论】TgAb与TRAb的联合检测在甲状腺癌诊断中具有较高的应用价值。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	李源
	贾雷鸣
	刘丰

关键词 ：甲状腺肿瘤, 甲状腺素结合球蛋白, 甲状腺激素类

Abstract：【Objective】To explore the diagnostic value of combined detection of thyroglobulin antibody (TgAb) and thyrotropin receptor antibody (TRAb) in thyroid cancer.【Methods】 A total of 85 patients with thyroid cancer were included in the observation group, and 92 patients with benign thyroid lesions served as the control group. Basic clinical data, imaging results, and serum levels of thyroglobulin (TG), thyroid-stimulating hormone (TSH), TgAb, and TRAb were compared between the two groups. Logistic regression was used to analyze the risk factors for thyroid cancer. The diagnostic value of TgAb and TRAb was assessed using the receiver operating characteristic (ROC) curve.【Results】 In the observation group, the proportions of patients with irregular tumor morphology, aspect ratio ≥1, microcalcifications, blurred margins, and hypoechoic patterns on imaging, as well as higher peak systolic velocity (PSV) and resistance index (RI), were significantly greater than those in the control group (P<0.05). The levels of TG, TSH, TgAb, and TRAb were also significantly higher in the observation group (P<0.05). Logistic regression analysis indicated that imaging features, TG, TSH, TgAb, and TRAb were all significant risk factors for thyroid cancer (P<0.05). The ROC curve analysis showed that the combined detection of TgAb and TRAb had an area under the curve (AUC) of 0.926, indicating high diagnostic accuracy.【Conclusion】 Combined detection of TgAb and TRAb has significant value in the diagnosis of thyroid cancer.

Key words： Thyroid Neoplasms Thyroxine-Binding Globulin Thyroid Hormones

收稿日期: 2024-12-02

中图分类号:

R736.1

引用本文:

李源, 贾雷鸣, 刘丰. TgAb与TRAb联合检测对甲状腺癌的诊断价值[J]. 医学临床研究, 2025, 42(7): 1131-1133.
LI Yuan, JIA Leiming, LIU Feng. Diagnostic Value of Combined Detection of TgAb and TRAb in Thyroid Cancer. JOURNAL OF CLINICAL RESEARCH, 2025, 42(7): 1131-1133.

链接本文:

http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2025.07.008 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2025/V42/I7/1131

[1] 中国抗癌协会甲状腺癌专业委员会.中国抗癌协会甲状腺癌整合诊治指南(2022精简版)[J].中国肿瘤临床,2023,50(7):325-330.
[2] KIM T H, LEE M Y, JIN S M, et al. The association between serum concentration of thyroid hormones and thyroid cancer: a cohort study[J].Endocr Relat Cancer,2022,29(12):635-644.
[3] 谢磊,柴凡,鲍刚,等.血清Tg、TgAb对甲状腺癌根治术联合¹³¹I治疗后随访期间复发/转移的评估价值[J].中国现代医学杂志,2023,33(19):74-79.
[4] ZHANG C F, ZHANG Q E, QIN L L,et al. Dioscin ameliorates experimental autoimmune thyroiditis via the mTOR and TLR4/NF-κB signaling[J].Drug Des Devel Ther,2023, 17(12):2273-2285.
[5] 中华医学会内分泌学分会,中华医学会外科学分会内分泌学组,中国抗癌协会头颈肿瘤专业委员会,等.甲状腺结节和分化型甲状腺癌诊治指南[J].中华核医学与分子影像杂志,2013,33(2):96-115.
[6] WEI B, YAO J C, PENG C J,et al. Clinical features and imaging examination assessment of cervical lymph nodes for thyroid carcinoma[J].BMC Cancer,2023, 23(1):1225.
[7] LI L, WANG Z, GUO H,et al. Nanomaterials: a promising multimodal theranostics platform for thyroid cancer[J].J Mater Chem B,2023,11(32):7544-7566.
[8] XIAO Q, JIA Q, TAN J,et al. Serum biomarkers for thyroid cancer[J].Biomark Med,2020,14(9):807-815.
[9] SHEN H Z, ZHU R, LIU Y Y,et al. Radioiodine-refractory differentiated thyroid cancer: Molecular mechanisms and therapeutic strategies for radioiodine resistance[J].Drug Resist Updat,2024,72:101013.
[10] KHAN M A, TANIA M. Cordycepin and kinase inhibition in cancer[J].Drug Discov Today,2023,28(3):103481.
[11] LIU Y J, ZHAO Y R, FU J,et al. Ultrasonographic differentiation and Ultrasound-based management of partially cystic thyroid nodules[J].Arch Endocrinol Metab,2021, 65(3):336-341.
[12] 杨光旭,万静,吴作辉,等.超微血管成像评估甲状腺影像报告和数据系统(TI-RADS)4级甲状腺结节血流特征[J].中国医学影像技术,2021,37(6):867-870.
[13] 宋青,康林立,兰雨,等.微血流成像模式鉴别甲状腺结节良恶性的价值[J].中国医学科学院学报,2022,44(1):40-44.
[14] WANG K, CHEN Q H, LIU N X,et al. Recent advances in, and challenges of, anti-angiogenesis agents for tumor chemotherapy based on vascular normalization[J].Drug Discov Today,2021,26(11):2743-2753.
[15] FROHLICH E, WAHL R. Pars Distalis and pars tuberalis thyroid-stimulating hormones and their roles in macro-thyroid-stimulating hormone formation[J].Int J Mol Sci,2023, 24(14):11699.