Abstract:【Objective】To explore the clinical application value of multimodal ultrasound in cervical lymph node metastasis of papillary thyroid carcinoma.【Methods】A retrospective analysis was conducted on the clinical data of 90 patients with PTC and cervical lymph node enlargement admitted to our hospital from August 2021 to July 2023. All selected patients underwent DUS CUES, UE inspection. Using pathological results as reference standards, DUS was analyzed Sensitivity, specificity, and accuracy of CUES and UE single and combined examinations in diagnosing cervical lymph node metastasis in PTC. The ultrasound characteristics of PTC patients with cervical lymph node metastasis and those without metastasis were analyzed.【Results】The pathological results of 90 patients with PTC and cervical lymph node enlargement showed that 55 patients (61.11%) had cervical lymph node metastasis, and 35 patients (38.89%) did not have cervical lymph node metastasis. The accuracy of DUS, CUES, and UE combined examination in diagnosing PTC with cervical lymph node metastasis was 92.22%(83/90), which was significantly higher than DUS (73.33%), CUES (80.00%) and UE(81.11%) single check, the difference was statistically significant (P<0.05). There was no significant difference in the sensitivity and specificity of joint diagnosis compared with CUES, but they were all higher than DUS, UE single item examination with statistically significant differences (P<0.05). The blood supply pattern, lesion tissue location, perfusion uniformity, elasticity score, edge regularity, and microcalcification of patients in the metastatic group were compared with those in the non metastatic group, and the differences were statistically significant (P<0.05).【Conclusion】The application of multimodal ultrasound in the clinical diagnosis of PTC cervical lymph node metastasis has high diagnostic efficacy. Clinical attention should be paid to lesions that exhibit peripheral blood flow patterns, lesions located in the upper and middle parts of the neck, irregular edges, microcalcifications, and other ultrasound features to improve diagnostic accuracy.