Abstract：【Objective】To explore the clinical effect of endoscopic dacryocystorhinostomy combined with self-cross-linked sodium hyaluronate gel in the treatment of dacryocystitis and its influence on dry eye symptoms in patients. 【Methods】A total of 92 patients with dacryocystitis admitted to our hospital from January 2019 to December 2022 were selected. The patients were divided into the observation group and the control group according to different treatment methods, with 46 cases in each group. The control group was treated with the traditional external nasal dacryocystorhinostomy, while the observation group was treated with endoscopic dacryocystorhinostomy combined with self-crosslinking sodium hyaluronate gel. The lacrimal gland secretion function (Schirmer Ⅰ test filter paper tear adhesion length), tear discharge degree score, tear film rupture time, ocular surface Disease Index Scale (OSDI) score, and inflammatory indicators [tumor necrosis factor-α(TNF-α), C-reactive protein (CRP), interleukin-6(IL-6), and interleukin-10 (IL-10)],bleeding conditions, and the occurrence and recurrence of postoperative complications were compared between the two groups. 【Results】One month after the operation, the tear staining length of the filter paper in the Schirmer Ⅰ test in the observation group was longer than that in the control group (P<0.05); Two months after the operation, the score of tear overflow degree in the observation group was lower than that in the control group (P<0.05). One month after the operation, The tear film break-up time in the observation group was longer than that in the control group (P<0.05). Two months after the operation, the OSDI score of the observation group was lower than that of the control group (P<0.05). One month after the operation, the levels of TNF-α, CRP and IL-6 in the observation group were lower than those in the control group, while the level of IL-10 was higher than that in the control group (P<0.05). The bleeding rate, the incidence of postoperative complications and the recurrence rate in the observation group were all lower than those in the control group (P<0.05). 【Conclusion】Endoscopic dacryocystorhinostomy combined with self-cross-linked sodium hyaluronate gel in the treatment of patients with dacryocystitis can significantly improve the secretory function of the lacrimal gland, effectively alleviate dry eye symptoms, reduce inflammatory responses, and lower the incidence and recurrence rate of postoperative complications. It is a safe and effective treatment method.
余超良. 鼻内镜下泪囊鼻腔吻合术联合自交联透明质酸钠凝胶治疗泪囊炎患者的疗效及对患者干眼症状的影响[J]. 医学临床研究, 2025, 42(6): 966-969.
YU Chaoliang. Effect of Endoscopic Dacryocystorhinostomy Combined with Cross-Linked Hyaluronic Acid Gel on the Treatment of Dacryocystitis and Dry Eye Symptoms. JOURNAL OF CLINICAL RESEARCH, 2025, 42(6): 966-969.
2025, Vol. 42 
