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医学临床研究  2024, Vol. 41 Issue (1): 81-84    DOI: 10.3969/j.issn.1671-7171.2024.01.022
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SOX2、CARM1在子宫内膜样腺癌 Ⅰ 期组织中的表达及其意义
闫瑞娟1, 张林燕2*
1.巴彦淖尔市医院妇科,内蒙古 巴彦淖尔 015000;
2.内蒙古医科大学附属医院妇产科, 内蒙古 呼和浩特 010059
The Expression and Clinical Significance of SOX2 and CARM1 in Stage Ⅰ Endometrioid Adenocarcinoma
YAN Ruijuan, ZHANG Linyan
Department of Gynaecology, the Bayannaoer Hospital,015000
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摘要 【目的】 探讨SOX2和CARM1在子宫内膜样腺癌Ⅰ期组织中的表达及其意义。【方法】 收集2013年1月至2015年12月内蒙古医科大学附属医院妇科收治的因高中分化子宫内膜样腺癌行全子宫双附件切除术患者的癌组织病理石蜡标本(观察组)和因子宫肌瘤、子宫腺肌症等良性疾病行子宫全切术患者的增生期子宫内膜病理石蜡标本(对照组)。采用免疫组化SP法检测两组相关基因簇2(SOX2)蛋白和精氨酸甲基转移酶1(CARM1)蛋白表达水平并比较。【结果】 观察组SOX2蛋白、CARM1蛋白阳性表达率显著高于对照组,差异有统计学意义(P<0.05)。在子宫内膜样腺癌中,SOX2与CARM1蛋白阳性表达均与组织学分化有关(P<0.05);与患者年龄、FIGO分期以及CA125值无关(P>0.05)。SOX2蛋白与CARM1蛋白在子宫内膜样腺癌中的表达呈正相关(P=0.010)。【结论】 高表达的SOX2蛋白与CARM1蛋白可能参与子宫内膜样腺癌的发病过程,二者协同促进子宫内膜样腺癌的发生与发展,在中分化组织中呈高表达状态,可能是导致子宫内膜样腺癌恶性行为的因素。
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闫瑞娟
张林燕
关键词 子宫内膜肿瘤/病理学SOXB2转录因子类    
Abstract:【Objective】 To explore the expression and clinical significance of SOX2 and CARM1 in stage Ⅰ endometrial adenocarcinoma tissue.【Methods】 Pathological paraffin specimens of cancer tissue from patients with total hysterectomy for high and medium differentiated endometrioid adenocarcinoma, who admitted to the Department of Gynecology at the Affiliated Hospital of Inner Mongolia Medical University from January 2013 to December 2015, were enrolled in the observation group. While proliferative endometrial pathological paraffin specimens from patients who underwent total hysterectomy due to benign diseases such as uterine fibroids and adenomyosis were recruited in the control group. Immunohistochemical SP method was used to detect the expression levels of SOX2 protein and CARM1 protein in two groups and the results were compared between the two groups. 【Results】 The positive expression rates of both SOX2 protein and CARM1 protein in the observation group were significantly higher than those in the control group, with a statistically significant difference (P<0.05). The positive expression of SOX2 and CARM1 protein was related to histological differentiation in endometrioid adenocarcinoma (P<0.05). However, their expression was not related to patients' age, International Federation of Gynecology and Obstetrics (FIGO) and CA125 value (P> 0.05). There was a significant positive correlation between SOX2 and CARM1 protein expression in in endometrioid adenocarcinoma (P=0.010). 【Conclusion】 Highly expressed SOX2 protein and CARM1 protein may be involved in the pathogenesis of endometrioid adenocarcinoma. The two synergistically promote the occurrence and development of endometrioid adenocarcinoma. The higher expression level of SOX2 and CARM1 was found in moderately differentiated EAC compared to well differentiated ones, which may be novel factors that cause malignant behavior.
Key wordsEndometrial Neoplasms/PA    SOXB2 Transcription Factors
收稿日期: 2023-08-09     
中图分类号:  R737.33  
通讯作者: *E-mail:zhanglinyan0471@163.com   
引用本文:   
闫瑞娟, 张林燕. SOX2、CARM1在子宫内膜样腺癌 Ⅰ 期组织中的表达及其意义[J]. 医学临床研究, 2024, 41(1): 81-84.
YAN Ruijuan, ZHANG Linyan. The Expression and Clinical Significance of SOX2 and CARM1 in Stage Ⅰ Endometrioid Adenocarcinoma. JOURNAL OF CLINICAL RESEARCH, 2024, 41(1): 81-84.
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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2024.01.022     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2024/V41/I1/81
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