Abstract：【Objective】 To explore the expressions of brainderived neurotrophic factor (BDNF) and tyrosine kinase receptor B (TrkB) in endometrial carcinoma and analyze their clinical significances. 【Methods】 The expressions of BDNF and TrkB were detected by immunohistochemistry in normal endometrium (n=22), hyperplasia endometrium (n=32) and endometrial carcinoma (n=62). And the relationship with their clinicopathological characteristics were analyzed. 【Results】 BDNF and TrkB were negatively or weakly positively expressed in normal endometrium while positively in hyperplasia endometrium and endometrial carcinoma. And statistically significant differences existed among three groups (P<0.05). The expressions of BDNF and TrkB in endometrial carcinoma were significantly correlated with tumor cell differentiation, clinicopathologic staging, myometrial invasion and lymph node metastasis of endometrial carcinoma (P<0.05). 【Conclusion】 The interaction of BDNF with TrkB may play an important synergistic role in the occurrence and development of endometrial carcinoma.
陈旭娜1 叶志中2**. 脑源性神经生长因子及酪氨酸激酶受体B在子宫内膜癌中的表达及其意义[J]. 医学临床研究, 2015, 32(8): 1477-1479.
CHEN Xu na, YE Zhi zhong. Expressions and Significances of BrainDerived Neurotrophic Factor and Tyrosine Kinase Receptor B in Endometrial Carcinoma. JOURNAL OF CLINICAL RESEARCH, 2015, 32(8): 1477-1479.
2015, Vol. 32 
