Abstract:【Objective】To investigate the value of indocyanine green angiography in the treatment of anterior circulation aneurysms by craniotomy. 【Methods】From March 2017 to March 2019, 90 cases of anterior circulation aneurysms were clipped by fluorescence-assisted microsurgery in neurosurgery department of Xiangtan Central Hospital. The clipping effect of aneurysms was evaluated by head CTA or DSA within 3 days after operation, and the prognosis was evaluated by GOS score three months after operation. 【Results】Six patients had parent artery stenosis after the first clipping. After changing the appropriate aneurysm clip or adjusting the position of the aneurysm clip, fluorescence angiography showed that the parent artery was unobstructed; 4 patients found residual aneurysm neck, 2 of these 4 patients added an aneurysm clip, and the other 2 timely adjusted the position of the aneurysm clip, and finally completely clipped the aneurysm. In 9 patients, the perforating vessels were mistakenly clipped. After angiography, the location of the aneurysm clip was adjusted to avoid the false clipping. The results of postoperative reexamination showed that there were no parent artery stenosis, residual tumor neck and perforating vessel injury in 90 patients. After 3 months of follow-up, all patients were evaluated by gos score. The GOS score was 4 points and 5 points in 68 cases, that is, mild disability but can live independently or return to normal life belongs to good recovery. The excellent and good rate of patients in this study was 75.6% (68/90). 【Conclusion】Indocyanine green fluorescence angiography assisted anterior circulation aneurysm clipping can effectively reduce the incidence of complications such as parent artery stenosis, residual aneurysm neck, perforating vessel injury, etc., and can improve the quality of life of patients, which has high clinical application value.