Abstract：【Objective】To investigate the diagnostic value of hypoxia-inducible factor-1a (HIF-1a) combined with the ratio of umbilical artery/middle cerebral artery (UA/MCA), ratio of renal artery/middle cerebral artery (RA/MCA)and venous catheter shunt rate (VCSR) in intrauterine distress. 【Methods】A total of 50 pregnant women with intrauterine distress received treatment in our hospital from January 2016 to May 2018 were selected as the observation group, while in the same period 60 normal pregnant women with birth examination were enrolled as the control group. All pregnant women took blood test to measure HIF-1a and received color Doppler ultrasound detection for fetal umbilical artery (UA), renal artery (RA) and middle cerebral artery (MCA). The maximum systolic flow rate/maximum diastolic flow rate (S/D)of MCA, the resistance index (RI), the pulse index (PI) and venous catheter shunt rate (VCSR) were calculated and compared between the two groups. 【Results】The detection value of maternal blood HIF-1a in observation group was higher than that in normal control group; The difference was statistically significant (P<0.05).The resistance ratio (S/D) of MCA and UA (MCA/UA), RI and PI in the observation group were significantly lower than those in the control group (P<0.05). Fetal RA and MCA resistance ratio of RA/MCA S/D, RI and PI in the observation group were significantly higher than those in the control group; The differences were statistically significant (P<0.05).The venous catheter shunt rate (VSCR) in the observation group was significantly higher than that in the control group. The difference was statistically significant (P<0.05).The fetal distress diagnostic sensitivity, specificity, positive predictive value, negative predictive value and the correct diagnosis rate of HIF-1a in combination with MCA/UA,RA/MCA and VCSR were significantly better than HIF-1a, MCA/UA, RA/MCA, VCSR alone. The differences were statistically significant (P<0.05). 【Conclusion】Maternal blood HIF-1a in combination with MCA/UA,RA/MCA and VCSR has higher diagnostic value for intrauterine distress which can provide timely clinical monitoring and intervention.
曹硕, 马征戈, 王园园, 李江华, 闫崇超. 缺氧诱导因子-1a联合MCA/UA和RA/MCA及VCSR在胎儿宫内窘迫中的诊断价值[J]. 医学临床研究, 2019, 36(12): 2326-2328.
CAO Shuo, MA Zheng-ge, WANG Yuan-Yuan, et al. Value of HIF-1a Combined with UA/MCA, RA/MCA and VSCR for Fetal Distress Diagnosis. JOURNAL OF CLINICAL RESEARCH, 2019, 36(12): 2326-2328.
2019, Vol. 36 
