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Quick Search     Adv Search 2024 Vol. 41, No. 1 Published: 2024-01-26 Review and lecture Original Articles          Original Articles 6 A Network Meta Analysis of Traditional Chinese Medicine External Treatment for Opioid Drug Related Constipation YAO Nian, XU Ran, HU Jiaji, et al DOI: 10.3969/j.issn.1671-7171.2024.01.002 【Objective】 To explore the efficacy of different traditional Chinese medicine external treatment methods in treating opioid related constipation through network meta-analysis. 【Methods】 Computer retrieval of literature on the treatment of opioid related constipation in cancer patients using traditional Chinese medicine external treatment methods in databases such as China National Knowledge Infrastructure, Wanfang, China Biomedical Literature Database, VIP, PubMed, Embase, Web of Science, and The Cochrane Library. The retrieval deadline is from the establishment of the database until March 20, 2023. At the same time, trace the relevant system evaluations and include references in the research. Two researchers independently screened the literature and extracted data to evaluate the quality of the literature. Statistical analysis was conducted using the Gemtc package from RevMan 5.3 software, Stata 17.0 software, and R 4.2.3 software. 【Results】 A total of 1570 patients were included in 17 studies, involving 7 intervention measures. The results of the network meta-analysis showed that the efficacy of acupoint application+conventional treatment (OR=7.00, 95%CI=3.90-13.00, P<0.05), moxibustion+conventional treatment (OR=6.20, 95%CI=2.20-21.00, P<0.05), and abdominal massage+conventional treatment (OR=8.80, 95%CI=2.40-46.00, P<0.05) was superior to conventional treatment. The SUCRA value showed that the top three traditional Chinese medicine external treatment methods in terms of efficacy were abdominal massage+conventional treatment (80.36%), acupoint application + conventional treatment (74.54%), and Moxibustion+conventional treatment (68.76%) respectively.【Conclusion】 It is recommended to use abdominal massage combined with conventional treatment to alleviate opioid related constipation. However, in practical clinical work, multiple factors such as patient willingness and physical condition should be considered for decision-making. 2024 Vol. 41 (1): 6-10 [Abstract] ( 47 ) HTML (1 KB)  PDF (1522 KB)  ( 114 ) 11 Clinical Effects of Conbercept in Combination with Vitrectomy for Proliferative Diabetic Retinopathy WANG Huiyan, HU Peng, JIANG Lijuan, et al DOI: 10.3969/j.issn.1671-7171.2024.01.003 【Objective】 To investigate the clinical effect of conbercept combined with vitrectomy (PPV) in the treatment of proliferative diabetic retinopathy (PDR). 【Methods】 Totally 46 patients (50 eyes) with PDR, who visited our hospital from August 2020 to October 2022, were selected as the study subjects, and they were randomly divided into two groups. There were 23 patients (25 eyes) in the conventional group who were treated with 23 G PPV alone and 23 patients (25 eyes) in the study group who were treated with conbercept-assisted 23 G PPV. Postoperative follow-up included a comparison of surgical duration and changes in intraoperative and postoperative conditions between the two groups. 【Results】 The average surgical duration in the study group was significantly lower than that in the conventional group (t=2.47, P<0.05). Postoperatively, the best corrected visual acuity (BCVA) in the study group was higher than that in the conventional group. Additionally, the rates of iatrogenic retinal break and retinal detachment treated with silicone oil tamponade were lower in the study group if compared to the conventional group (P<0.05). 【Conclusion】 PDR patients treated with conbercept-assisted 23 G PPV can effectively reduce surgical duration, enhance postoperative visual acuity, and decrease the incidence of complications. 2024 Vol. 41 (1): 11-13 [Abstract] ( 33 ) HTML (1 KB)  PDF (1157 KB)  ( 46 ) 14 Comparison of Minimally Invasive Single-incision Endobutton Plate with Clavicle Hook Plate in Treatment of Rockwood Ⅲ Acromioclavicular Dislocation HE Zhiling, SHUANG Feng, WANG Chao, et al DOI: 10.3969/j.issn.1671-7171.2024.01.004 【Objective】 To compare the effects of minimally invasive single-incision endobutton plate with clavicle hook plate in the treatment of Rockwood Ⅲacromioclavicular joint dislocation. 【Methods】 A total of 33 patients with Rockwood Ⅲ acromioclavicular joint dislocation who were treated in our hospital from January 2016 to January 2018 were selected and divided into the endobutton plate group (the observation group,16 cases)and the clavicle hook plate group(the control group,17 cases) according to the random number table.The perioperative indicators, operating time, hospital stays, intraoperative blood loss, length of the incision, shoulder pain(visual analogue scale,VAS) score,shoulder function Constant-Murley score and postoperative complications were compared between the two groups. 【Results】 The length of the incision and hospital stays in the observation group were shorter than those in the control group (P<0.05). The intraoperative blood loss in the observation group was less than that in the control group (P<0.05). After 1 week,1 month,3 months, 6 months and the last time of follow- up,the Constant-Murley score of the observation group was higher than that of the control group and the VAS score of the observation group was lower than that of the control group (P<0.05). The complication rate of the observation group was 12.5%(2/16), which was significantly lower than that of control group 52.9%(9/17), and the difference was statistically significant (P<0.05). 【Conclusion】 For patients with Rockwood Ⅲ acromioclavicular joint dislocation, Single-incision double button plate fixation obtains less complications, fewer operative trauma and good shoulder joint function, which is an ideal treatment. 2024 Vol. 41 (1): 14-17 [Abstract] ( 34 ) HTML (1 KB)  PDF (1436 KB)  ( 72 ) 18 The Correlation between Chemerin, Gal-3, Visfatin and Recurrence after First Catheter Radiofrequency Ablation in Patients with Atrial Fibrillation ZHANG Lixia, DONG Jinli DOI: 10.3969/j.issn.1671-7171.2024.01.005 【Objective】 To explore the correlation between serum levels of Galactin-3 (Gal-3), Visfatin, and Chemerin and recurrence after first catheter radiofrequency ablation in patients with atrial fibrillation.【Methods】 A total of 184 patients with atrial fibrillation admitted to our hospital from August 2019 to August 2021 were selected. All patients underwent radiofrequency ablation treatment after admission. They were divided into a recurrence group (n=53) and a non recurrence group (n=131) based on whether they recurred within 6 months after surgery. We compared two clinical data sets and serum levels of Chemerin, Gal-3, and Visfatin before and 1 month after surgery, and analyzed the correlation and predictive value of these indicators with postoperative recurrence of atrial fibrillation at 1 month after surgery.【Results】 The proportion of recurrent group, concomitant hypertension, coronary heart disease, and left atrial volume index (LAVI) were higher than those of the non recurrent group, and the left ventricular ejection fraction (LVEF) was higher than those of the non recurrent group, with statistical significance (P<0.05). The serum levels of Gal-3, Visfatin, and Chemerin in the recurrent group were higher than those in the non recurrent group before and 1 month after surgery, with statistical significance (P<0.05). Logistic regression analysis showed that serum Gal-3, Visfatin, and Chemerin levels at one month post surgery were independent risk factors for postoperative atrial fibrillation recurrence (P<0.05). The risk of postoperative atrial fibrillation recurrence in patients with high levels of Gal-3, Visfatin, and Chemerin was 4.076 times, 2.847 times, and 6.272 times higher than that in patients with low levels (P<0.05).【Conclusion】 Serum Gal-3, Visfatin, and Chemerin are closely related to postoperative recurrence in patients with atrial fibrillation after the first radiofrequency ablation, which can predict the risk of postoperative recurrence in patients early and help clinical physicians formulate targeted treatment plans to reduce recurrence rates. 2024 Vol. 41 (1): 18-21 [Abstract] ( 43 ) HTML (1 KB)  PDF (1188 KB)  ( 42 ) 22 Clinical Efficacy of Microscopic and Foraminal Surgery in the Treatment of Lumbar Disc Herniation CHEN Tao, TONG Xinzhou, ZHENG Yang, et al DOI: 10.3969/j.issn.1671-7171.2024.01.006 【Objective】 To investigate the efficacy and safety of microsurgical lumbar discectomy (MSLD) and percutaneous endoscopic lumbar discectomy (PELD)in the treatment of lumbar disc herniation. 【Methods】 A total of 486 patients with lumbar disc herniation undergoing minimally invasive surgery at Loudi Central Hospital from December 2013 to May 2022 were retrospectively analyzed. Among them, 192 patients underwent MSLD treatment (the MSLD group) and 294 patients underwent PELD (the PEID group). The pain visual simulation scores (visual analogue scale, VAS), the muscle strength score (manual muscle testing, MMT) at 1 week, 3 months, 6 months, 12 months and 24 months after surgery and complication rates were compared between the two groups. 【Results】 The VAS scores of the two groups at each time point after surgery were significantly lower than those before surgery(P<0.05); however, there were no statistically significant differences in the VAS scores at each time point before and after treatment between the two groups (P>0.05). The MMT scores of the two groups of patients at each time point after surgery were significantly higher than those before surgery(P<0.05); however, there were no statistically significant differences in the MMT scores at each time point before and after treatment between the two groups (P>0.05).The total complication rate in the MSLD group was 2.60%(5/192), which was significantly lower than the 8.50%(25/294) in the PELD group, and the difference was statistically significant (P<0.05). 【Conclusion】 Both MSLD and PELD can effectively reduce the pain of patients with lumbar disc herniation. PELD is operated under local anesthesia, which can check the muscle strength of lower limbs, the feedback of pain and numbness during the operation. Its warning effect can reduce nerve damage and reduce the incidence of complications. 2024 Vol. 41 (1): 22-24 [Abstract] ( 48 ) HTML (1 KB)  PDF (1224 KB)  ( 43 ) 25 Correlation between the Expression of miR-143 and miR-33a in Peripheral Blood and the Clinical Prognosis of Bladder Cancer Patients GAO Yonghui, PENG Beibei DOI: 10.3969/j.issn.1671-7171.2024.01.007 【Objective】 To investigate the relationship between the expression of miR-143 and miR-33a in peripheral blood and the clinical prognosis of bladder cancer patients. 【Methods】 A total of 60 patients with bladder cancer admitted to our hospital from May 2017 to April 2021 (observation group) were selected, and 60 healthy volunteers who underwent physical examination in the same period were selected as the control group. The expression levels of miR-143 and miR-33a in the peripheral blood of the two groups of subjects and the expression levels of miR-143 and miR-33a in the peripheral blood of patients with different pathological characteristics were compared. The diagnostic value of miR-143 and miR-33a in the peripheral blood for bladder cancer was evaluated. The survival curves of bladder cancer patients with different expressions of miR-143 and miR-33a in the peripheral blood were compared. The relationship between the expression of miR-143 and miR-33a in the peripheral blood and the death risk of bladder cancer patients was analyzed.【Result】 The expression levels of miR-143 and miR-33a in the peripheral blood of the observation group were lower than those of the control group, and the difference was statistically significant (P<0.05). The expression levels of miR-143 and miR-33a in peripheral blood of patients with different clinical stages, degree of tissue differentiation, initial and recurrent stages, and presence or absence of distant metastasis were compared, and the differences were statistically significant (P<0.05). The area under the curve of miR-143 and miR-33a in the combined diagnosis of bladder cancer was 0.922, significantly higher than that of miR-143 and miR-33a (P<0.05). The postoperative 3-year survival rates of patients with low expression of miR-143 and miR-33a in peripheral blood were lower than those of patients with high expression of miR-143 and miR-33a in peripheral blood (P<0.05). The 3-year postoperative mortality risk of patients with low expression of miR-143 and miR-33a in peripheral blood is 4.550 times and 5.223 times higher than that of patients with high expression (P<0.05).【Conclusion】 The expression of miR-143 and miR-33a in the peripheral blood of patients with bladder cancer is down regulated, which is closely related to the pathological characteristics. The detection of their expression level is helpful to evaluate the prognosis of patients, and has high clinical value. 2024 Vol. 41 (1): 25-28 [Abstract] ( 32 ) HTML (1 KB)  PDF (1375 KB)  ( 21 ) 29 The Correlation between Life Satisfaction and Mental Health of Left Behind Children WANG Rui, MA Xiang, ZHOU Yanlin DOI: 10.3969/j.issn.1671-7171.2024.01.008 【Objective】 To explore the correlation between life satisfaction and psychological health of left behind children.【Methods】 A random sampling method was used to conduct a survey questionnaire on 202 left behind children (left behind children group) and 202 non left behind children (non left behind children group) in the local area. A questionnaire survey was conducted on left behind children and non left behind children using the Life Satisfaction Scale and 90 Symptom Checklist (SCL-90). The life satisfaction and SCL-90 scores of the two groups of research subjects were compared, and the life satisfaction and SCL-90 scores of left behind children of different genders were compared. Pearson correlation analysis was used to examine the correlation between life satisfaction and SCL-90 scores of left behind children.【Results】 The life satisfaction scores and SCL-90 scores of somatization, obsessive-compulsive symptoms, interpersonal sensitivity, depression, anxiety, hostility, terror, paranoia, and psychosis in the left behind children group were higher than those in the non left behind children group, and the differences were statistically significant (P<0.05). There was no statistically significant difference (P>0.05) in the life satisfaction scores of left behind children of different genders and the somatization, obsessive-compulsive symptoms, interpersonal sensitivity, depression, anxiety, hostility, terror, paranoia, and other scores of the SCL-90 scale. Pearson correlation analysis showed that life satisfaction of left behind children was significantly negatively correlated with somatization, obsessive-compulsive symptoms, interpersonal sensitivity, depression, anxiety, hostility, terror, paranoia, psychosis, and other scores(P<0.05).【Conclusion】 The life satisfaction and mental health level of left behind children are lower than those of non left behind children, and the life satisfaction of left behind children is closely related to their mental health status. 2024 Vol. 41 (1): 29-31 [Abstract] ( 31 ) HTML (1 KB)  PDF (1219 KB)  ( 59 ) 32 The Efficacy of Letrozole Combined with Urinary Gonadotropin in the Treatment of Infertility Patients with Polycystic Ovary Syndrome and its Impact on IL-6, CRP, and TNF-α Levels SHAN Linling, KANG Hongmei DOI: 10.3969/j.issn.1671-7171.2024.01.009 【Objective】 To explore the therapeutic effect of letrozole combined with urotropin in the treatment of infertility patients with polycystic ovary syndrome and its effects on interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor (TNF-α).【Methods】 A total of 94 infertile patients with polycystic ovary syndrome treated at the Ankang Traditional Chinese Medicine Hospital from January 2019 to January 2021 were collected. They were randomly divided into an observation group and a control group, with 47 cases in each group, using a random number table method. The control group received treatment with letrozole, while the observation group received combined treatment with urotropin on the basis of the control group. We compared the ovulation and pregnancy status of two groups, as well as the levels of endometrial receptivity [endometrial thickness, resistance index (RI), pulsatility index (PI)], inflammatory factors (IL-6, CRP, TNF-α), sex hormones [estradiol (E2), testosterone (T), follicle stimulating hormone (FSH), and luteinizing hormone (LH)] before and after treatment. 【Results】 Compared with the control group, the observation group had a higher ovulation rate and pregnancy rate (P<0.05); After treatment, the thickness of the endometrium in both groups increased, and the thickness of the endometrium in the observation group was greater than that in the control group (P<0.05); After treatment, there was no statistically significant difference in RI and PI levels between the two groups (P>0.05); After treatment, the serum levels of IL-6, CRP, and TNF-α decreased in both groups, and the observation group was lower than the control group (P<0.05); After treatment, the levels of E2, FSH, and LH in both groups increased, while the levels of T decreased. The levels of E2, FSH, and LH in the observation group were higher than those in the control group, while the levels of T were lower than those in the control group (P<0.05).【Conclusion】 The combination of letrozole and urotropin can improve the levels of sex hormones and endometrial receptivity in infertile patients with polycystic ovary syndrome, alleviate chronic inflammation, increase ovulation and pregnancy rates, and is worthy of clinical promotion and application. 2024 Vol. 41 (1): 32-35 [Abstract] ( 37 ) HTML (1 KB)  PDF (1185 KB)  ( 53 ) 36 Analysis of Abnormal Blood Test of AIDS Patients in Prison DENG Dongsheng, YAO Xiaoyan DOI: 10.3969/j.issn.1671-7171.2024.01.010 【Objective】 To investigate the blood test of AIDS patients in prison.【Methods】 Eighty AIDS patients serving sentences in this prison from November 2019 to June 2023 were selected as the observation group, and 80 healthy prisoners serving sentences at the same time were selected as the control group, and the hematological testing of all selected subjects was analyzed. 【Results】 The number of CD4+T lymphocytes, CD8+T lymphocytes, red blood cells, hemoglobin, and lymphocyte ratio in the control group were significantly higher than those in the observation group (P<0.05); The levels of C-reactive protein (CRP), alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and serum total bilirubin in the control group were significantly lower than those in the observation group, while the levels of cholinesterase, albumin/globulin, total protein, and albumin were significantly higher than those in the observation group (P<0.05). 【Conclusion】 Hematological testing can understand the immune function of the body, and can be used for early diagnosis and treatment monitoring of AIDS, so as to detect and timely intervene AIDS as soon as possible, improve the quality of life of patients and extend life span, which is of positive significance for AIDS diagnosis. 2024 Vol. 41 (1): 36-38 [Abstract] ( 32 ) HTML (1 KB)  PDF (1155 KB)  ( 35 ) 39 Clinical Value of Serum CRP, RDW and NT-proBNP in Predicting Different Severity of Chronic Obstructive Pulmonary Disease Complicated with Heart Failure CHANG Kaiyue, CHEN Xueqian DOI: 10.3969/j.issn.1671-7171.2024.01.011 【Objective】 To investigate the clinical value of serum CRP (C-reactive protein), RDW (red blood cell distribution width) and NT-proBNP in predicting different severity of chronic obstructive pulmonary disease complicated with heart failure. 【Methods】 A total of 90 patients with chronic obstructive pulmonary disease (COPD) admitted to the Department of Infectious Diseases of The First Affiliated Hospital of Xi'an Jiaotong University Yulin Hospital,the Department of Respiratory and Critical Care Medicine of Ankang Hospital of Traditional Chinese Medicine from October 2019 to December 2020 were selected. According to the examination results and clinical manifestations, the patients were divided into the simple COPD group (50 cases) and the COPD combined with heart failure group (40 cases). Another 50 healthy volunteers who underwent physical examination during the same period were selected as the control group. The serum levels of CRP, RDW and NT-proBNP were compared among the three groups. Forty patients with COPD combined with heart failure group were further divided into grade Ⅱ, Ⅲ and Ⅳ according to cardiac function complianced with New York Heart Association classification (NYHA). Serum levels of CRP, RDW and NT-proBNP were compared among different grades. The relationship of short-term efficacy with levels of CRP, RDW and NT-proBNP in patients with different severity were analyzed. The receiver operating characteristic (ROC) curve was used to analyze the predictive value of CRP, RDW and NT-proBNP alone and in combination in chronic obstructive pulmonary disease patients with heart failure.【Results】 The levels of serum CRP, RDW and NT-proBNP in the simple COPD group and the COPD combined with heart failure group were higher than those in the control group. The levels of serum CRP, RDW and NT-proBNP in the COPD combined with heart failure group were higher than those in the simple COPD group (P<0.05). The levels of serum CRP, RDW and NT-proBNP in patients with grade Ⅳ and Ⅲ COPD combined with heart failure were higher than those in grade Ⅱ (P<0.05). The levels of serum CRP, RDW and NT-proBNP in patients with grade IV COPD were higher than those in grade Ⅲ (P<0.05). The levels of RDW and pro-BNP in patients with the acute exacerbation phase of chronic obstructive pulmonary disease were higher than those in stable stage (P<0.05). In terms of treatment effect, the clinical treatment efficiency of patients in stable stage was higher than that in acute exacerbation stage (P<0.05). The sensitivity and specificity of serum CRP, RDW and NT-proBNP in predicting COPD patients with heart failure were higher than those of single test. 【Conclusion】 The levels of serum CRP, RDW and NT-proBNP in patients with chronic obstructive pulmonary disease complicated with heart failure are abnormally elevated, and their levels are closely related to the severity of the disease and prognosis. The combined detection of the three is of great significance for judging the patient's condition, guiding treatment and evaluating the prognosis. 2024 Vol. 41 (1): 39-42 [Abstract] ( 32 ) HTML (1 KB)  PDF (1309 KB)  ( 68 ) 43 Clinical Efficacy of Pudilan Anti-inflammatory Oral Liquid Combined with Tobramycin Eye Drops in the Treatment of Bacterial Keratitis YANG Fan, WANG Guan, FANG Ying DOI: 10.3969/j.issn.1671-7171.2024.01.012 【Objective】 To explore the clinical efficacy of Pudilan anti-inflammatory oral liquid combined with Tobramycin eye drops in the treatment of bacterial keratitis. 【Methods】 A total of 82 patients with bacterial keratitis admitted to our hospital from April 2020 to April 2023 were randomly divided into an observation group and a control group, with 41 cases in each group, using a random number table method. The control group was treated with tobramycin eye drops, while the observation group was treated with Pudilan anti-inflammatory oral solution in addition to the control group. Both groups were treated for 14 days. We compared the clinical efficacy, incidence of adverse reactions, clinical symptom scores before and after treatment, levels of interferon γ(IFN-γ), interleukin-6 (IL-6), tumor necrosis factor-α(TNF-α), and immune function indicators between two groups. 【Results】 After treatment, the pain symptom score, secretion symptom score, ulcer area symptom score, and conjunctival congestion symptom score of both groups decreased (P<0.05), and the observation group had a lower score (P<0.05). The total effective rate of the observation group was 92.68%, significantly higher than the control group's 75.61%, and the difference was statistically significant (P<0.05). Compared with before treatment, the serum IFN-γ levels in both groups increased after treatment (P<0.05), and the observation group had a higher level (P<0.05); After treatment, the serum levels of IL-6 and TNF-α decreased in both groups (P<0.05), and the observation group had lower levels (P<0.05). Compared with before treatment, the levels of CD3+ and CD4+ in both groups increased after treatment (P<0.05), and the observation group had a higher level (P<0.05); After treatment, the levels of CD8+ decreased in both groups (P<0.05), and the observation group had a lower level (P<0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P>0.05).【Conclusion】 The combination of Pudilan anti-inflammatory oral liquid and Tobramycin eye drops is effective in treating bacterial keratitis, improving clinical symptoms and immune function, reducing inflammatory reactions, and is safe and reliable. 2024 Vol. 41 (1): 43-46 [Abstract] ( 23 ) HTML (1 KB)  PDF (1180 KB)  ( 51 ) 47 Application of Linked Color Imaging Combined with Chemical Staining Technique in the Classification of Laterally Spreading Tumor of Large Intestine QIN Shizhao, PAN Xiaoli, YIN Yuefei, et al DOI: 10.3969/j.issn.1671-7171.2024.01.013 【Objective】 To explore the application of linked color imaging (LCI) combined with chemical staining technology in the classification of laterally spreading tumor of colorectal tumors (LST). 【Methods】 The examination images of 82 patients with colorectal tumors (89 lesions) diagnosed by LCI combined with chemical staining technology in our hospital were retrospectively analyzed, and the morphology of small pits on the surface of the lesions of the patients was evaluated. The characteristics of the lesions was predicted according to the morphological classification of small glandular canal opening (Pit) on the mucosal surface, And the Pit classification was compared with the pathologic results after endoscopic resection. 【Results】 The diagnosis of type Ⅰ, Ⅱ and Ⅱ-0 were mostly serrated lesions (SSP)/hyperplastic polyps (HP). The sensitivity, specificity and accuracy were 55.56%, 96.25% and 92.13%, respectively. The sensitivity, specificity and accuracy of type ⅢS alone in the diagnosis of submucosal invasive carcinoma with an invasion depth ≥100 mm (SMd) were 20.00%, 98.81%, and 94.38%, respectively. The sensitivity, specificity and accuracy of the diagnosis of low-grade dysplasia (LGD)/high-grade dysplasia (HGD) for types ⅢL and Ⅳ were 92.31%, 83.33%, and 89.89%, respectively. The sensitivity, specificity and accuracy of type Ⅴn alone in the diagnosis of SMd were 40.00%, 97.62%, and 94.38%, respectively. The sensitivity, specificity and accuracy of type Ⅴi and Ⅴn in the diagnosis of intramucosal carcinoma or submucosal invasive carcinoma with an invasion depth of less than 100 mm (m-SMs)/SMd were 86.67%, 97.30%, and 95.51%, respectively. The sensitivity, specificity and accuracy of type ⅢS and type Ⅴn in the diagnosis of SMd were 60.00%, 96.43%, and 94.38%, respectively. 【Conclusion】 LCI combined with chemical staining can accurately and completely display the Pit shape of rectal mass, which makes it easier to assess whether the mass is neoplasm. And the predicted depth of tumor invasion of the has a high coincidence rate with the pathological diagnosis result. 2024 Vol. 41 (1): 47-50 [Abstract] ( 29 ) HTML (1 KB)  PDF (1443 KB)  ( 18 ) 51 The Correlation between Coronary Artery Calcium Score and Short-Term Prognosis after Coronary Artery Disease Interventional Surgery ZHANG Hongwei, LI Xinguo DOI: 10.3969/j.issn.1671-7171.2024.01.014 【Objective】 To explore the correlation between Coronary Artery Calcium Score (CCS) and the short-term prognosis of patients with Coronary Artery Disease (CAD) after interventional surgery. 【Methods】 A total of 120 patients who underwent coronary artery interventional treatment and coronary artery CT angiography (CTA) were included in the study. CCS was calculated for each patient. Patients were followed up for 6 months outside the hospital to record the occurrence of major adverse cardiac events (MACE) and the survival time without events. Based on those information, patients were divided into two groups: the poor prognosis group (n=27) and the good prognosis group (n=93). The relationship and predictive value of CCS in patients with their prognosis were analyzed. 【Results】 The age, CCS, serum creatinine (Scr), and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels in the poor prognosis group were significantly higher than those in the good prognosis group (P<0.05). The time without MACE and Left Ventricular Ejection Fraction (LVEF) were significantly lower in the poor prognosis group compared to the good prognosis group (P<0.05).CCS showed a positive correlation with age (r=0.518, P<0.05) and Scr (r=0.407, P<0.05), and a negative correlation with LVEF (r=-0.215, P<0.05).The area under the curve (AUC) of the receiver operating characteristic (ROC) curve for predicting MACE using CCS was 0.84(95%CI: 0.76-0.92).CCS, LVEF, and NT-proBNP were correlated with poor prognosis in patients, with odds ratios (OR) (95%CI) of 1.46 (0.61-3.49), 1.01 (0.98-1.05), and 1.24 (1.03-1.82), respectively. 【Conclusion】 CCS is an independent risk factor for poor short-term prognosis in patients undergoing interventional treatment for CAD and is a potential clinical indicator for assessing MACE. 2024 Vol. 41 (1): 51-53 [Abstract] ( 32 ) HTML (1 KB)  PDF (1240 KB)  ( 36 ) 54 Effects of Qingxuan Jieyu Decoction on Blood Pressure, Homocysteine, and Vascular Endothelial Growth Factor Levels in Elderly Patients with Hypertension and Vertigo WANG Liang, WANG Xiaorong DOI: 10.3969/j.issn.1671-7171.2024.01.015 【Objective】 To explore the effects of Qingxuan Jieyu Decoction on blood pressure and levels of homocysteine (Hcy) and vascular endothelial growth factor (VEGF) in elderly patients with hypertension and vertigo. 【Methods】 A total of 102 elderly patients with hypertension and vertigo treated at two hospital were randomly divided into an observation group (Qingxuan Jieyu Decoction + Western medicine treatment) and a control group (Western medicine treatment), with 51 patients in each group. The therapeutic effect, adverse reactions, traditional Chinese medicine (TCM) syndrome scores, systolic blood pressure (SBP), diastolic blood pressure (DBP), dizziness assessment rating scale (DARS) scores, and levels of Hcy and VEGF before and after treatment were compared in both groups. 【Results】 The total effective rate in the observation group was 88.24%, which was significantly higher than 70.59% in the control group (P<0.05). After treatment, scores for vertigo, headache, chest tightness, irritability, palpitations, and insomnia in both groups were significantly lower than before treatment, with the observation group showing even lower scores than the control group (P<0.05). After treatment, SBP, DBP, and DARS scores in both groups were significantly lower than before treatment (P<0.05), and the observation group showed even lower scores of SBP, DBP, and DARS than the control group (P<0.05). After treatment, levels of Hcy and VEGF in both groups were significantly lower than before treatment, while levels of Hcy and VEGF in the observation group were lower than those in the control group (P<0.05). The total incidence of adverse reactions in both groups showed no significant difference (P>0.05). 【Conclusion】 Qingxuan Jieyu Decoction can effectively alleviate vertigo symptoms in elderly patients with hypertension and vertigo, control blood pressure levels, protect vascular endothelial function, and has few adverse reactions. 2024 Vol. 41 (1): 54-57 [Abstract] ( 27 ) HTML (1 KB)  PDF (1180 KB)  ( 64 ) 58 The Influence of Traditional Chinese Medicine Brain-awakening Acupuncture on the Recovery of Limb Function during the Rehabilitation Phase in Patients with Post-stroke Hemiplegia GUO Bao, SU Xing, REN Xuezhi, et al DOI: 10.3969/j.issn.1671-7171.2024.01.016 【Objective】 To explore the effect of brain-awakening acupuncture and moxibustion on the recovery process of limb function of stroke patients with hemiplegia during rehabilitation. 【Methods】 A total of 102 patients with post-stroke hemiplegia were randomly divided into two groups, with 51 cases in each group. The patients in the control group received routine rehabilitation training, and the patients in the observation group were treated with traditional Chinese medicine (TCM) acupuncture and moxibustion on this basis; After treatment for 4 weeks, the clinical efficacy, traditional Chinese medicine symptom scores, Brunnstrom staging, motor function [fugl meyer motor function (FMA) assessment scale, berg balance scale (BBS)], neurological function, and daily living activities [national institutes of health stroke scale (NIHSS), modified Rankin Scale (mRS)] were compared between two groups of patients【Results】 The total effective rate of the observation group was higher than that of the control group (P<0.05). After treatment, the scores of symptoms such as dark red tongue, dark purple claws, dull complexion, numbness, swelling of hands and feet, and dark lips and gums in both groups of patients decreased compared to before treatment (P<0.05), and the observation group had lower scores than the control group (P<0.05). After treatment, the proportion of Brunnstrom stage Ⅲ in the upper limbs, lower limbs, and hands in the observation group was higher than that in the control group (P<0.05). After treatment, the FMA upper and lower limb scores and BBS scores in both groups increased compared to before treatment (P<0.05), and the FMA upper and lower limb scores and BBS scores in the observation group were higher than those in the control group after treatment (P<0.05). After treatment, the NIHSS score and mRS score of both groups decreased compared to before treatment (P<0.05), and the observation group had lower NIHSS score and mRS score than the control group after treatment (P<0.05).【Conclusion】 Brain-awakening acupuncture and moxibustion can effectively improve the TCM syndromes of hemiplegia patients in the rehabilitation period after stroke, improve the Brunstrom stage and motor ability of limbs, and improve neural function defects. The comprehensive effect is good, and it is recommended to promote its application. 2024 Vol. 41 (1): 58-61 [Abstract] ( 27 ) HTML (1 KB)  PDF (1178 KB)  ( 41 ) 62 Clinical Significance of Serum sVCAM1, MIF and IgE in Patients with Acute Asthma LIANG Caiyan, MA Min DOI: 10.3969/j.issn.1671-7171.2024.01.017 【Objective】 To explore the changes of adhesion factor (sVCAM1), macrophage migration inhibitory factor (MIF) and immunoglobulin E (IgE) expressed by serum soluble vascular endothelial cells during the acute attack of bronchial asthma and their prognostic value. 【Methods】 A total of 126 patients with acute attack of bronchial asthma and 110 patients with non-acute attack of bronchial asthma admitted to our hospital from October 2018 to March 2021 were recorded as acute attack group and non-acute attack group, respectively, and 100 healthy volunteers were recorded as the control group. The serum sVCAM1, MIF and IgE levels of the three groups of subjects were compared. The prognosis of patients with acute attack of bronchial asthma was analyzed and divided into the poor prognosis group and the good prognosis group according to treatment progress and recovery degree. The clinical data of the poor prognosis group and the good prognosis group were compared. Logistic multivariate regression analysis of factors affecting the prognosis of patients with acute bronchial asthma attacks. A receiver operating characteristic curve (ROC) was made to analyze the predictive value of serum sVCAM1, MIF and IgE on the prognosis of patients with acute bronchial asthma attacks. 【Results】 The serum sVCAM1, MIF and IgE levels of the three groups were compared, and the differences were statistically significant (P<0.05). The levels of serum sVCAM1, MIF and IgE in the acute attack group were higher than those in the non-acute attack group and the control group (P<0.05). The serum sVCAM1, MIF and IgE levels of patients in the acute attack group were higher than those in the non-acute attack group (P<0.05). In this study, the incidence of adverse prognosis in patients with acute attack of bronchial asthma during hospitalization was 16.67%. The hospital stay, severity ratio, sVCAM1, MIF and IgE in the poor prognosis group were higher than those in the good prognosis group (P<0.05), and the forced expiratory volume in one second (FEV1)/forced lung capacity (FVC) in the poor prognosis group were lower than those in the good prognosis group (P<0.05).Logistic multivariate analysis showed that severity of the disease, elevated serum sVCAM1, elevated MIF and elevated IgE were all risk factors affecting the prognosis of patients with acute attack of bronchial asthma (OR=2.795, 3.142, 3.022, 3.449, P<0.05). ROC analysis showed that the best cut-off points of serum sVCAM1, MIF, and IgE for predicting the prognosis of patients with acute bronchial asthma attacks were 467.92 ng/L, 51.02 ng/mL, and 285.96 IU/ml, respectively. The area under the curve (AUC) of the triple combination was 0.890, which was higher than the AUC predicted by serum sVCAM1, MIF and IgE alone (P<0.05). 【Conclusion】 The expression of serum sVCAM1, MIF and IgE is higher in patients with acute bronchial asthma, and the combination of the three has a higher prognostic effect on patients with acute bronchial asthma. 2024 Vol. 41 (1): 62-65 [Abstract] ( 27 ) HTML (1 KB)  PDF (1290 KB)  ( 24 ) 66 Clinical Value of Predicting Long-term Prognosis of STEMI Patients with White Blood Cell/Average Platelet Volume QI Jiangang, LIU Xiqin DOI: 10.3969/j.issn.1671-7171.2024.01.018 【Objective】 To investigate the clinical value of white blood cell/mean platelet volume (WMR) in predicting the long-term prognosis of patients with acute ST-segment elevation myocardial infarction (STEMI). 【Methods】 A total of 161 patients with acute STEMI admitted to the Cardiology Department of our hospital from May 2017 to September 2019 were selected and treated with percutaneous coronary intervention (PCI). The patients were divided into a good prognosis group (n=32) and a poor prognosis group (n=129) based on their clinical prognosis. The clinical indicators of the two groups were compared, and multivariate logistic regression analysis was used to analyze the correlation between clinical indicators and long-term adverse prognosis of acute STEMI patients. The receiver operating characteristic (ROC) curve was used to evaluate the value of relevant clinical indicators in predicting the long-term prognosis of acute STEMI patients. 【Results】 The levels of cTnI, LDL-C, WBC, MPV, and WMR in the good prognosis group were significantly lower than those in the poor prognosis group, but the LVEF was higher than that in the poor prognosis group, with statistically significant differences (P<0.05). Multivariate logistic regression analysis showed that WMR, cTnI, MPV, and LVEF were associated with adverse prognosis in patients with acute STEMI (P<0.05), with odds ratios of 3.41, 5.18, 1.18, and 0.91, respectively. ROC curve analysis showed that cTnI had the highest predictive value for adverse prognosis in STEMI patients, significantly higher than WMR, MPV, and LVEF (P<0.01); WMR had a higher predictive value for adverse prognosis in STEMI patients than MPV and LVEF (P<0.05); the optimal diagnostic threshold of WMR was 0.63. Kaplan-Meier survival curve analysis showed that the survival time without major adverse cardiovascular events (MACEs) in the high WMR group was significantly lower than that in the low WMR group (P=0.033). 【Conclusion】 WMR is a potential clinical indicator for predicting the long-term prognosis of STEMI patients and is worthy of clinical reference. 2024 Vol. 41 (1): 66-69 [Abstract] ( 30 ) HTML (1 KB)  PDF (1226 KB)  ( 27 ) 70 Effect of Nifedipine Combined with Hemodialysis on Inflammation Level and Renal Function in Patients with Chronic Kidney Disease DU Wenwen DOI: 10.3969/j.issn.1671-7171.2024.01.019 【Objective】 To observe the clinical efficacy of nifedipine combined with hemodialysis in the treatment of chronic kidney disease (CKD),and effects on inflammation levels and renal function. 【Methods】 A total of 98 CKD patients who received regular hemodialysis(HD) in our hospital were randomly divided into the dialysis group (HD treatment) and the combined group (nifedipine combined with HD treatment), with 49 cases in each group. The levels of inflammatory factors, renal function, blood fat and oxidative stress indicators before and after treatment were compared between the two groups. The clinical efficacy and safety of the two groups were compared as well. 【Results】 After treatment, the levels of plasminogen activator inhibitor-1 (PAI-1), tumor necrosis factor-α (TNF-α), adiponectin, uric acid, serum creatinine (Scr), urea nitrogen (BUN), 24 h urine protein quantification, β2-microglobulin (β2-MG), total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL-C), malondialdehyde (MDA) in the combined group were lower than those in the dialysis group (P<0.05), while the glomerular filtration rate (eGFR), high-density lipoprotein cholesterol (HDL-C), catalase (CAT), glutathione peroxidase (GSH-Px) were higher than those in the dialysis group (P<0.05). The total effective rate of the combined group was higher than that of the dialysis group (P<0.05). There were no significant abnormality in blood routine and liver function before and after treatment in both groups, and no allergic reaction, drug intolerance or serious adverse reaction were found. 【Conclusion】 Nifedipine combined with HD can improve renal function and clinical efficacy of CKD patients, reduce inflammatory response and oxidative stress, reduce blood fat, and has high safety. 2024 Vol. 41 (1): 70-73 [Abstract] ( 32 ) HTML (1 KB)  PDF (1244 KB)  ( 56 ) 74 The Predictive Value of Plasma Lysophosphatidic Acid Receptor 1 Levels on the Prognosis of Hypertensive Intracerebral Hemorrhage Patients LIU Tao, ZHANG Hui, XU Fanye DOI: 10.3969/j.issn.1671-7171.2024.01.020 【Objective】 To explore the predictive value of plasma lysophosphatidic acid receptor 1 (LPAR1) levels on the prognosis of hypertensive intracerebral hemorrhage patients. 【Methods】 A total of 130 patients with hypertensive intracerebral hemorrhage admitted to our hospital from March 2016 to March 2020 were selected as the observation group, and 50 healthy individuals who underwent physical examinations at our hospital during the same period were selected as the control group. The plasma LPAR1 levels of two groups were detected using enzyme-linked immunosorbent assay (ELISA), and all patients were divided into a good prognosis group (n=67) and a poor prognosis group (n=63) based on the Glasgow Outcome Scale (GOS) scores after 30 days of onset. The factors affecting the poor prognosis of patients in the observation group were analyzed using multiple logistic regression, and the receiver operating characteristic (ROC) curve was plotted to evaluate the predictive value of plasma LPAR1 levels and poor prognosis in patients with hypertensive intracerebral hemorrhage. 【Results】 The plasma LPAR1 levels in the observation group were higher than those in the control group, and the difference was statistically significant (P<0.05). The difference in bleeding volume, NIHSS score, and treatment plan between the group with good prognosis and the group with poor prognosis was statistically significant (P<0.05). The plasma LPAR1 levels in patients with poor prognosis were higher than those in those with good prognosis, and the difference was statistically significant (P<0.05). Multivariate logistic regression analysis showed that LPAR1>4.22 μg/L and NIHSS score>(23.62±2.55) scores were independent risk factors for poor prognosis in patients with hypertensive intracerebral hemorrhage (P<0.05). ROC curve analysis showed that the AUC of plasma LPAR1 level for diagnosing poor prognosis in patients with hypertensive intracerebral hemorrhage was 0.857 (95%CI: 0.753-0.869), with a cutoff value of 3.68 μmol/L, with sensitivity and specificity of 81.3% and 85.6%, respectively.【Conclusion】 Plasma LPAR1 levels have certain predictive value for the prognosis of patients with hypertensive intracerebral hemorrhage, and can provide some reference for early clinical evaluation of patient prognosis. 2024 Vol. 41 (1): 74-77 [Abstract] ( 31 ) HTML (1 KB)  PDF (1202 KB)  ( 15 ) 78 Analysis of Nutritional Status and Influencing Factors of Malnutrition in Hospitalized Elderly Patients with Mental Disorders LI Xuan, LI Chao, JIAO Xueping, et al DOI: 10.3969/j.issn.1671-7171.2024.01.021 【Objective】 To explore the nutritional status and influencing factors of malnutrition in hospitalized elderly patients with mental disorders.【Methods】 A total of 397 hospitalized elderly patients with mental disorders admitted to our hospital from January 2018 to December 2021 were selected. They were divided into malnutrition group (n=63) and malnutrition group (n=334) using the Nutrition Risk Screening 2002 (NRS 2002) scale. We collected clinical data from two groups of patients and analyzed the influencing factors of malnutrition in elderly hospitalized psychiatric patients using a logistic multiple regression model.【Results】 The swallowing function, nutritional support, SDS score, SAS score, PANSS score of the malnutrition group were compared with those of the malnutrition group, and the differences were statistically significant (P<0.05). Logistic regression analysis showed that swallowing dysfunction, lack of nutritional support, SDS score>41.84, SAS score>42.41, and PANSS score>57.92 were risk factors for malnutrition in elderly hospitalized psychiatric patients. 【Conclusion】 Elderly hospitalized psychiatric patients have a higher risk of malnutrition, with swallowing function, nutritional support, SDS score, SAS score, and PANSS score as influencing factors. Clinicians can develop targeted treatment plans based on this to further improve patient prognosis. 2024 Vol. 41 (1): 78-80 [Abstract] ( 34 ) HTML (1 KB)  PDF (1218 KB)  ( 42 ) 81 The Expression and Clinical Significance of SOX2 and CARM1 in Stage Ⅰ Endometrioid Adenocarcinoma YAN Ruijuan, ZHANG Linyan DOI: 10.3969/j.issn.1671-7171.2024.01.022 【Objective】 To explore the expression and clinical significance of SOX2 and CARM1 in stage Ⅰ endometrial adenocarcinoma tissue.【Methods】 Pathological paraffin specimens of cancer tissue from patients with total hysterectomy for high and medium differentiated endometrioid adenocarcinoma, who admitted to the Department of Gynecology at the Affiliated Hospital of Inner Mongolia Medical University from January 2013 to December 2015, were enrolled in the observation group. While proliferative endometrial pathological paraffin specimens from patients who underwent total hysterectomy due to benign diseases such as uterine fibroids and adenomyosis were recruited in the control group. Immunohistochemical SP method was used to detect the expression levels of SOX2 protein and CARM1 protein in two groups and the results were compared between the two groups. 【Results】 The positive expression rates of both SOX2 protein and CARM1 protein in the observation group were significantly higher than those in the control group, with a statistically significant difference (P<0.05). The positive expression of SOX2 and CARM1 protein was related to histological differentiation in endometrioid adenocarcinoma (P<0.05). However, their expression was not related to patients' age, International Federation of Gynecology and Obstetrics (FIGO) and CA125 value (P> 0.05). There was a significant positive correlation between SOX2 and CARM1 protein expression in in endometrioid adenocarcinoma (P=0.010). 【Conclusion】 Highly expressed SOX2 protein and CARM1 protein may be involved in the pathogenesis of endometrioid adenocarcinoma. The two synergistically promote the occurrence and development of endometrioid adenocarcinoma. The higher expression level of SOX2 and CARM1 was found in moderately differentiated EAC compared to well differentiated ones, which may be novel factors that cause malignant behavior. 2024 Vol. 41 (1): 81-84 [Abstract] ( 26 ) HTML (1 KB)  PDF (1821 KB)  ( 28 ) 85 The Value of Ultrasonography Combined with Serum CEA and AFP Levels in the Differential Diagnosis of Breast Cancer TIAN Xiuli, LI Jinsong DOI: 10.3969/j.issn.1671-7171.2024.01.023 【Objective】 To investigate the clinical diagnostic value of ultrasonography combined with carcinoembryonic antigen (CEA) and alpha fetoprotein (AFP) in breast cancer. 【Methods】 A total of 90 patients with breast cancer (breast cancer group, n=90) and 87 patients with benign breast nodules (benign breast nodules group, n=87) admitted to our hospital from April 2019 to April 2023 were selected, and 100 healthy female volunteers (control group) were selected in the same period. All subjects were examined by ultrasound and serum CEA and AFP levels. The clinical diagnostic value of ultrasound combined with CEA and AFP in breast cancer was analyzed by receiver operating characteristic (ROC) curve. 【Results】 Vmax, RI and PI in breast cancer group were significantly higher than those in the benign breast nodules group and the control group (P<0.05). Serum CEA and AFP levels in the breast cancer group were significantly higher than those in the benign breast nodules group and the control group (P<0.05). Ultrasound combined with CEA and AFP had the highest diagnostic value for breast cancer (AUC=0.930), and the predictive sensitivity was 93.0% and 97.5%, respectively, which were higher than any single detection index (P<0.05). 【Conclusion】 Ultrasonography combined with CEA and AFP has high clinical value in the diagnosis of breast cancer. Compared with single detection, its combined application can significantly improve the diagnostic sensitivity and specificity of breast cancer. 2024 Vol. 41 (1): 85-87 [Abstract] ( 28 ) HTML (1 KB)  PDF (1235 KB)  ( 47 ) 88 The Effect of Inspiratory Muscle Training Combined with Weight-bearing Training on Joint Function Recovery and Incidence of Pulmonary Infection in Patients Undergoing Rehabilitation Training after Hip Replacement Surgery SHI Yaqin, SHENG Yani, WANG Zhaoli DOI: 10.3969/j.issn.1671-7171.2024.01.024 【Objective】 To explore the effects of inspiratory muscle training combined with weight-bearing training on joint function recovery and pulmonary infection incidence in patients undergoing rehabilitation training after hip replacement surgery.【Methods】 A total of 100 patients who underwent hip replacement surgery at the Xingyuan Hospital in Yulin City from January 2020 to January 2022 were selected and randomly divided into an observation group and a control group, with 50 patients in each group, using a random number table method. 7 days after hip replacement surgery, the control group received routine breathing training combined with weight-bearing rehabilitation training, while the observation group received inspiratory muscle training in addition to the control group. Two groups of pulmonary function indicators [forced expiratory volume at 1 second (FEV1), forced vital capacity (FVC), peak expiratory flow rate (PEF), and maximum expiratory pressure (MIP)], hip joint function, quality of life, and incidence of complications were compared before and after intervention. 【Results】 After intervention, both groups showed an increase in lung function indicators, hip joint function scores, and quality of life scores (P<0.05), with the observation group showing a more significant increase (P<0.05); The incidence of complications in the observation group was significantly lower than that in the control group (P<0.05). 【Conclusion】 The combination of inspiratory muscle training and weight-bearing training can promote the recovery of lung function and hip joint function in patients undergoing hip replacement surgery during the perioperative period, improve their quality of life, reduce the incidence of complications such as pulmonary infections, and have high clinical application value. 2024 Vol. 41 (1): 88-91 [Abstract] ( 27 ) HTML (1 KB)  PDF (1178 KB)  ( 55 ) 92 The Value of Escitalopram Combined with Magnesium Valproate in the Treatment of Depression Patients YANG Jian, LIU Zhe, FENG Yuhong DOI: 10.3969/j.issn.1671-7171.2024.01.025 【Objective】 To explore the efficacy of escitalopram combined with magnesium valproate in the treatment of depression. 【Methods】 A total of 84 depression patients who were treated at Xianyang Hospital of Yan'an University were randomly divided into two groups, with 42 patients in each group.The control group was treated with oral escitalopram, while the observation group was treated with a combination of escitalopram and magnesium valproate. We compared the treatment efficacy, hamilton depression scale (HAMD) scores, hamilton anxiety scale (HAMA) scores, wisconsin card sorting test (WCST) scores, and levels of 5-hydroxytryptamine (5-HT) and norepinephrine (NE) between two groups before and after treatment, as well as the occurrence of adverse reactions after treatment. 【Results】 The total effective rate of the observation group was 76.19%(32/42), significantly higher than the control group's 54.76%(23/42), and the difference was statistically significant (P<0.05); After treatment, the HAMD and HAMA scores of both groups were lower than before treatment (P<0.05), and the observation group was lower than the control group (P<0.05); After treatment, the levels of 5-HT and NE in both groups were higher than before treatment (P<0.05), and the observation group was higher than the control group (P<0.05); After treatment, the WCST scores in both groups were significantly better than before treatment (P<0.05), and the observation group was better than the control group (P<0.05); There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P>0.05).【Conclusion】 Escitalopram combined with magnesium valproate can effectively alleviate depression and anxiety in patients with depression, improve cognitive function, and have good safety. 2024 Vol. 41 (1): 92-94 [Abstract] ( 21 ) HTML (1 KB)  PDF (1221 KB)  ( 34 ) 95 Clinical Efficacy and Safety Analysis of the Combination of Vedolizumab and Mesalazine in the Treatment of Inflammatory Bowel Disease MA Zhenzhen, ZHU Bingyang, FANG Jintao DOI: 10.3969/j.issn.1671-7171.2024.01.026 【Objective】 To explore the clinical efficacy and safety of combination therapy with Vedolizumab and Mesalazine in the treatment of inflammatory bowel disease.【Methods】 A total of 84 patients with inflammatory bowel disease admitted to the First Affiliated Hospital of Nanyang Medical College from January 2021 to December 2022 were selected. They were randomly divided into a conventional group and a combination group using a random number table method, with 42 patients in each group. The conventional group was given Mesalazine, while the combination group was given Vedrizumab in addition to the conventional group. The treatment effect was observed in both groups at week 8. We compared the clinical efficacy, peripheral blood inflammatory factors [serum interleukin-4 (IL-4), interleukin-17 (IL-17)], and inflammatory bowel disease quality of life questionnaire (IBDQ) scores between two groups, and recorded the occurrence of adverse drug reactions during treatment.【Results】 The total effective rate of the combined group was 95.24%(40/42), which was higher than the conventional group's 78.57%(33/42), and the difference was statistically significant (χ2=5.126, P<0.05). After treatment, the serum levels of IL-4 and IL-17 in both groups of patients were lower than before treatment, and the combined group was lower than the conventional group, with statistical significance (P<0.05). The IBDQ scores of the conventional group and the combination group before treatment were (115.89±12.93) points and (113.27±11.85) points, respectively. After treatment, the scores of the two groups were (182.34±15.48) points and (198.15±7.26) points, respectively. After treatment, the IBDQ scores of the two groups of patients were higher than before treatment, and the combination group was higher than the conventional group, with a statistically significant difference (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (χ2=0.156, P=0.693). 【Conclusion】 The combination of Vedolizumab and Mesalazine in the treatment of inflammatory bowel disease can enhance the therapeutic effect, inhibit the synthesis of inflammatory factors, improve the quality of life of patients, and have good safety. 2024 Vol. 41 (1): 95-98 [Abstract] ( 32 ) HTML (1 KB)  PDF (1182 KB)  ( 45 ) 99 Effect of Panlongqi Tablets Combined with Nabumetone on Pain and Serum-Related Indicators in Patients with Lumbar Disc Herniation LIU Ji DOI: 10.3969/j.issn.1671-7171.2024.01.027 【Objective】 To explore the effect of Panlongqi tablets combined with nabumetone on pain symptoms and serum-related indicators in patients with lumbar disc herniation. 【Methods】 A total of 60 patients with lumbar disc herniation were randomly divided into an observation group and a control group, each with 30 patients. The control group received conventional medication + nabumetone treatment, while the observation group received Panlongqi tablets on top of the control group's treatment. The pain relief, serum inflammatory indicators, lumbar spine function indicators, clinical efficacy, and incidence of adverse reactions were compared in both groups. 【Results】 After 6, 9, and 12 weeks of treatment, the visual analog scale (VAS) scores in the observation group were lower than those in the control group. After treatment, serum tumor necrosis factor-alpha (TNF-α), interleukin-17 (IL-17), interleukin-1β (IL-1β) levels in the observation group were lower than those in the control group (P<0.05). The Oswestry Disability Index (ODI) scores in the observation group after 3, 6, 9, and 12 weeks of treatment were lower than those in the control group (P<0.05). The total effective rate in the observation group (80.00%) was higher than that in the control group (53.33%) (P<0.05). And the incidence of adverse reactions in both groups showed no significant difference (P>0.05). 【Conclusion】 Panlongqi tablets combined with nabumetone in treating patients with lumbar disc herniation can significantly alleviate pain symptoms, reduce serum inflammatory levels, and improve lumbar spine function with significant clinical effects and high medication safety. 2024 Vol. 41 (1): 99-101 [Abstract] ( 24 ) HTML (1 KB)  PDF (1214 KB)  ( 49 ) 102 The Application Effect of Early Swallowing Function Training Combined with Non Nutritive Sucking in Premature Infants with Difficulty in Oral Feeding HUO Jingyu, KE Lijun, WANG Qi DOI: 10.3969/j.issn.1671-7171.2024.01.028 【Objective】 To explore the application effect of early swallowing function training combined with non nutritive sucking in premature infants with difficulty in oral feeding.【Methods】 A total of 92 premature infants with oral feeding difficulties admitted to our hospital from November 2019 to December 2020 were randomly divided into a control group and an observation group, with 46 cases in each group. The control group received non nutritional sucking intervention, while the observation group received early swallowing function rehabilitation training intervention in combination with the control group. Before and 10 days after intervention, the growth and development indicators, gastrointestinal function recovery, and incidence of complications were compared between the two groups of children. 【Results】 After intervention, the weight, length, and head circumference of the two groups of patients were higher than before intervention, and the observation group was higher than the control group, with statistical significance (P<0.05). The observation group had shorter retention time of nasogastric tube, recovery time of body mass, and time to achieve total intestinal nutrition compared to the control group, and the increase in milk intake was higher than that of the control group, with statistical significance (P<0.05). The incidence of complications in the observation group was 2.17%(1/46), lower than the control group's 15.22%(7/46), and the difference was statistically significant (χ2=4.929, P<0.05).【Conclusion】 Implementing non nutritive suction combined with early swallowing function rehabilitation training for premature infants with difficulty in oral feeding can promote the growth and development of premature infants and the recovery of gastrointestinal function, reduce the incidence of complications, and is worthy of clinical reference. 2024 Vol. 41 (1): 102-105 [Abstract] ( 24 ) HTML (1 KB)  PDF (1175 KB)  ( 74 ) 106 The Effect of Different Blood Transfusion Volume Interventions on Coagulation Function in Elderly Patients with Severe Trauma YU Hongyun, QU Changjing, ZHU Feng, et al DOI: 10.3969/j.issn.1671-7171.2024.01.029 【Objective】 To observe the effect of different transfusion volumes on coagulation function in elderly patients with severe trauma. 【Methods】 A total of 110 severe trauma patients treated in our hospital were randomly divided into an observation group and a control group, with 55 cases in each group. All patients were given basic treatments such as oxygen therapy, anti infection, and anti shock. The control group received a small amount of blood transfusion intervention, while the observation group received a large amount of blood transfusion intervention, closely monitoring the changes in vital signs of patients after blood transfusion intervention. We compared the incidence and mortality rates of inflammation, coagulation function, blood gas, and multiple organ dysfunction syndrome (MODS) in two groups of patients before and three days after intervention. 【Results】 Three days after intervention, the levels of C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α(TNF-α) in the two groups of patients were significantly higher than before intervention (P<0.05), and the levels of various indicators in the observation group were higher than those in the control group (P<0.05); Three days after intervention, the levels of prothrombin time (PT), activated partial thromboplastin time (APTT), and thrombin time (TT) in two groups of patients were significantly higher than before intervention, while the levels of fibrinogen (FIB) and platelet count (PLT) were significantly lower than before intervention (P<0.05). In addition, the levels of PT, APTT, and TT in the observation group were higher than those in the control group, while the levels of FIB and PLT were lower than those in the control group (P<0.05); Three days after intervention, the pH and arterial oxygen pressure (PaO2) levels of the two groups of patients were significantly higher than before intervention, and the arterial carbon dioxide pressure (PaCO2) levels were significantly lower than before intervention (P<0.05). In addition, the pH and PaO2 levels of the observation group were higher than those of the control group, and the PaCO2 levels were lower than those of the control group (P<0.05); The incidence and mortality rate of MODS in the observation group were significantly lower than those in the control group (P<0.05). 【Conclusion】 The application of extensive blood transfusion intervention in elderly patients with severe trauma can effectively supplement their blood volume, improve blood gas indicators, and reduce mortality, but it is prone to trigger inflammatory reactions and lead to coagulation dysfunction. Therefore, when applying blood transfusion intervention to elderly patients with severe trauma, it is necessary to reasonably control the transfusion dose and closely monitor relevant indicators such as coagulation function. 2024 Vol. 41 (1): 106-108 [Abstract] ( 26 ) HTML (1 KB)  PDF (1226 KB)  ( 29 ) 109 Clinical Efficacy and Impact on Immune Function of Wushe Rongpi Decoction in the Treatment of Maintenance Hemodialysis Patients with Skin Itching YANG Xuemei, YU Guangqing, LI Wenli, et al DOI: 10.3969/j.issn.1671-7171.2024.01.030 【Objective】 To explore the clinical efficacy of Wushe Rongpi decoction in maintenance hemodialysis (MHD) patients with skin itching and its impact on their immune function. 【Methods】 A total of 100 patients with MHD accompanied by skin itching admitted to our hospital were randomly divided into an observation group and a control group, with 50 cases in each group. The control group received routine clinical treatment, while the observation group received Wushe Rongpi decoction. The clinical efficacy and incidence of adverse reactions were compared between the two groups after treatment. The TCM symptom score, immune function indicators, and serum levels of interleukin-2 (IL-2), interleukin-6 (IL-6), and tumor necrosis factor-α(TNF-α) were compared before and after treatment. 【Results】 The total effective rate of patients in the observation group was 92.00%, which was higher than 78.00% in the control group (P<0.05); The scores of skin itching, dark red rash, and increased erythema in the observation group after treatment were lower than those before treatment and in the control group after treatment (P<0.05); After treatment, the levels of CD3+ and CD4+ in the observation group were significantly higher than those before treatment and the control group, while the levels of CD8+ were significantly lower than those before treatment and the control group (P<0.05); The levels of IL-2, IL-6, and TFN-α in the observation group after treatment were lower than those before treatment and in the control group (P<0.05); There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05).【Conclusion】 The use of Wushe Rongpi decoction in the treatment of MHD patients with skin itching has a significant therapeutic effect, can improve the patient's immune function, reduce serum IL-2, IL-6, TFN-α levels, and traditional Chinese medicine symptom scores, and has minimal adverse reactions. 2024 Vol. 41 (1): 109-112 [Abstract] ( 31 ) HTML (1 KB)  PDF (1185 KB)  ( 33 )

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