Abstract 【Objective】 To explore the predictive value of plasma lysophosphatidic acid receptor 1 (LPAR1) levels on the prognosis of hypertensive intracerebral hemorrhage patients. 【Methods】 A total of 130 patients with hypertensive intracerebral hemorrhage admitted to our hospital from March 2016 to March 2020 were selected as the observation group, and 50 healthy individuals who underwent physical examinations at our hospital during the same period were selected as the control group. The plasma LPAR1 levels of two groups were detected using enzyme-linked immunosorbent assay (ELISA), and all patients were divided into a good prognosis group (n=67) and a poor prognosis group (n=63) based on the Glasgow Outcome Scale (GOS) scores after 30 days of onset. The factors affecting the poor prognosis of patients in the observation group were analyzed using multiple logistic regression, and the receiver operating characteristic (ROC) curve was plotted to evaluate the predictive value of plasma LPAR1 levels and poor prognosis in patients with hypertensive intracerebral hemorrhage. 【Results】 The plasma LPAR1 levels in the observation group were higher than those in the control group, and the difference was statistically significant (P<0.05). The difference in bleeding volume, NIHSS score, and treatment plan between the group with good prognosis and the group with poor prognosis was statistically significant (P<0.05). The plasma LPAR1 levels in patients with poor prognosis were higher than those in those with good prognosis, and the difference was statistically significant (P<0.05). Multivariate logistic regression analysis showed that LPAR1>4.22 μg/L and NIHSS score>(23.62±2.55) scores were independent risk factors for poor prognosis in patients with hypertensive intracerebral hemorrhage (P<0.05). ROC curve analysis showed that the AUC of plasma LPAR1 level for diagnosing poor prognosis in patients with hypertensive intracerebral hemorrhage was 0.857 (95%CI: 0.753-0.869), with a cutoff value of 3.68 μmol/L, with sensitivity and specificity of 81.3% and 85.6%, respectively.【Conclusion】 Plasma LPAR1 levels have certain predictive value for the prognosis of patients with hypertensive intracerebral hemorrhage, and can provide some reference for early clinical evaluation of patient prognosis.
LIU Tao,ZHANG Hui,XU Fanye. The Predictive Value of Plasma Lysophosphatidic Acid Receptor 1 Levels on the Prognosis of Hypertensive Intracerebral Hemorrhage Patients[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(1): 74-77.
[1] REZNIK M E, FAKHRI N, MOODY S, et al. Arrival blood pressure in hypertensive and non-hypertensive spontaneous intracerebral hemorrhage[J].J Neurol Sci,2020, 416(52):117000-117009.
[2] ZHANG Y M, SHI F, WANG C Q, et al. Analysis of clinical effect of humanized nursing mode on patients with hypertensive cerebral hemorrhage[J].Panminerva Med,2020, 95(2):1-10.
[3] 张建好, 李留霞, 郭瑞霞, 等. 妊娠期高血压疾病溶血磷脂酸及其受体的变化及意义[J].现代妇产科进展, 2009, 18(12):905-909.
[4] ALIOLI C A, DEMESMAY L, LAURENCIN-DALACIEUX S, et al. Expression of the type 1 lysophosphatidic acid receptor in osteoblastic cell lineage controls both bone mineralization and osteocyte specification[J].Biochim Biophys Acta Mol Cell Biol Lipids,2020, 1865(8):158715-158721.
[5] 骆明涛, 伍聪, 陶传元, 等. 《高血压性脑出血中国多学科诊治指南》急救诊治解读[J].中国急救医学, 2021, 41(3):185-190.
[6] TSAI H H, LEE B C, HUANG C Y, et al. Asymptomatic striatocapsular slit-like hemorrhage as a severity marker in patients with hypertensive angiopathy[J].J Stroke Cerebrovasc Dis, 2020, 29(10):105153-105159.
[7] MAHENDRA V, CLARK S L, SURESH M S. Neuropathophysiology of preeclampsia and eclampsia: A review of cerebral hemodynamic principles in hypertensive disorders of pregnancy[J].Pregnancy Hypertens,2021, 23(58):104-111.
[8] XIAO N, LIU T L, LI H, et al. Low serum uric acid levels promote hypertensive intracerebral hemorrhage by disrupting the smooth muscle cell-elastin contractile unit and upregulating the Erk1/2-MMP axis[J].Transl Stroke Res,2020, 11(5):1077-1094.
[9] AMALIA L, DALIMONTHE N Z. Clinical significance of Platelet-to-White Blood Cell Ratio (PWR) and National Institute of Health Stroke Scale (NIHSS) in acute ischemic stroke[J].Heliyon,2020, 6(10):e05033-e05039.
[10] EMANYI F, RAGHUNATHAN V. Lysophosphatidic acid and il-6 trans-signaling interact via YAP/TAZ and STAT3 signaling pathways in human trabecular meshwork cells[J].Invest Ophthalmol Vis Sci,2020, 61(13):29-38.
[11] 李祥雯, 金虹, 王志梅. 子痫前期患者胎盘组织中Edg2蛋白和mRNA的表达及意义[J].中国优生与遗传杂志, 2016, 24(11):76-78.
[12] 侯小红, 周桂银, 向成明, 等. 小鼠脑出血后继发性脑损伤调节因子Lpar1 mRNA和miR-200b的筛选、靶向关系预测验证[J].山东医药, 2020, 60(27):1-5.
2024, Vol. 41 
