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Quick Search     Adv Search 2019 Vol. 36, No. 4 Published: 2019-04-30   625 Clinical Application of Long Subcutaneous Jugular Tunnel-internal Jugular Vein-central Venous Catheter Implantation to Improve Catheter-related Blood Flow Infection in Elderly Patients WANG Feng-ling, MA Yan-na, MENG Qing-bo, et al DOI: 10.3969/j.issn.1671-7171.2019.04.001 【Objective】Clinical value of long subcutaneous jugular tunnel-internal jugular vein-central venous catheter implantation (LSJICC) in improving catheter-related bloodstream infections (CRBSIs) in elderly patients.【Methods】 Three hundred and forty-six elderly patients who needed central venous catheterization in our hospital from January 2013 to October 2016 were selected. All patients were followed up for one year. The distribution of pathogens in CRBSSIs patients was analyzed. Cox regression model was used to screen independent influencing factors on the prognosis of CRBSI patients.【Results】The poor prognosis rate was 9.54%. The top three pathogens of CRBSIs were Staphylococcus aureus, Acinetobacter baumannii and Candida. Multivariate Cox regression showed that age, smoking, catheterization time, type of bacteria and type of disease had significant influence on the poor prognosis of patients after operation (P<0.05).【Conclusion】LSJICC has certain clinical value in preventing CRBSIs in elderly patients. 2019 Vol. 36 (4): 625-627 [Abstract] ( 92 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 628 Study on Relationship between Thickness of Retinal Nerve Fiber Layer and Diopter WANG Lu, WANG Hong-tao, XUE Chun-yan DOI: 10.3969/j.issn.1671-7171.2019.04.002 【Objective】To study the relationship between the thickness of retinal nerve fiber layer and diopter. 【Methods】 A total of 90 eyes from 53 myopia patients in our department of ophthalmology between June 2014 to March 2016 were selected. The retinal nerve fiber layer (RNFL) thickness and axial length of patients were measured by optical correlation tomography (OCT). The relationship between RNFL thickness and diopter was analyzed by linear regression. 【Results】The mean RNFL thickness of 90 eyes from 53 myopic patients was (107.01±14.14)μm. There was no significant difference between men and women (P>0.05). RNFL thickness was positively correlated with diopter (r=0.347,P=0.001) and negatively correlated with axial length (r=-0.585,P=0.000). 【Conclusion】In the measurement of RNFL thickness, the impact of diopter and axial length should be considered to avoid misdiagnosis that may result in irreversible change in patients with glaucoma. 2019 Vol. 36 (4): 628-630 [Abstract] ( 94 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 631 Effect of Olanzapine and Risperidone on Cognition and Lipid Metabolism in Patients with Schizophrenia GUO Jun, JIA Rui-rong DOI: 10.3969/j.issn.1671-7171.2019.04.003 【Objective】To investigate the effects of olanzapine on cognitive function and lipid metabolism in patients with first-episode schizophrenia. 【Methods】Forty patients with first-episode schizophrenia diagnosed in our hospital from March 2015 to May 2017 were divided into the risperidone group and the olanzapine group. The patients in both groups were treated for 8 weeks. The positive symptom score, negative symptom score, PANSS total score, serum triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and cognitive function scores before and after treatment were compared between the two groups.【Results】After treatment, the positive symptoms, negative symptoms and PANSS total scores of the two groups were significantly lower than those of the same group before treatment (P<0.05), but the difference between the two groups was not statistically significant (P>0.05). Before treatment, the serum levels of TG, TC, HDL-C and LDL-C in the two groups were not statistically significant (P>0.05). After treatment, the serum levels of TG, TC and LDL-C in the two groups were significantly higher than those before treatment (P<0.05), and the serum TG and TC levels in the risperidone group were lower than those in the olanzapine group (P<0.05). After treatment, the SOP, CPT-IP, WMS-Ⅲ, HVLT-R, BVMT, NAB, and MSCEIT scores of the two groups were significantly higher than those of the same groups before treatment (P<0.05). 【Conclusion】Patients with first-episode schizophrenia treated with olanzapine and risperidone can effectively improve clinical symptoms and cognitive function; however, olanzapine has more pronounced effect on blood lipids than risperidone. 2019 Vol. 36 (4): 631-633 [Abstract] ( 62 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 634 Diagnostic Value of VAT and Serum Hcy in Elderly Patients with Posterior Circulation Ischemic Cerebral Infarction SU Jie, LI Yan-lan, CHANG Zhi-jun DOI: 10.3969/j.issn.1671-7171.2019.04.004 【Objective】To explore the clinical significance of vestibular rotation test (VAT) and serum homocysteine (Hcy) in elderly patients with posterior circulation ischemic cerebral infarction.【Methods】From November 2015 to October 2017, 98 elderly patients with posterior circulation ischemic cerebral infarction and 30 healthy persons were selected. The VAT and serum Hcy levels of the two groups were compared, and the diagnostic sensitivity, specificity, positive likelihood ratio and negative likelihood ratio were evaluated. 【Results】The increase rate of VAT horizontal and vertical gain and serum Hcy level in the observation group were significantly higher than those in the control group (P<0.05); the positive rate of VAT test, abnormal rate of serum Hcy, positive rate of combined detection of VAT and serum Hcy in the observation group were significantly higher than those in the control group (P<0.05); the specificity and positive likelihood of combined detection of VAT and serum Hcy in the observation group were significantly higher than those in the control group alone (P<0.05). VAT test and serum Hcy test were used (P<0.05).【Conclusion】VAT test alone can improve the diagnostic accuracy of senile posterior circulation ischemic cerebral infarction, and combined with serum Hcy test can further evaluate the development and prognosis of the disease, which has good clinical application value. 2019 Vol. 36 (4): 634-636 [Abstract] ( 82 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 637 Effects of IMB Model Combined with Continuous Nursing on Neurological Function Recovery, Lower Limb Function and Complications in Patients with Cerebral Infarction Treated by Bridging ZHONG Gui-ying, JIA Sheng-ju, HUANG Cheng-ping DOI: 10.3969/j.issn.1671-7171.2019.04.005 【Objective】To explore the effects of information-motivation-behavioral skills (IMB) model combined with continuous nursing on neurological function recovery, lower limb function, and complications in patients with cerebral infarction treated by bridging. 【Methods】 A total of 90 patients with cerebral infarction treated by bridging from January 2015 to October 2018 were randomly divided into the observation group and the control group. Patients in the control group received routine continuing nursing measures, while patients in the observation group were given IMB model combined with continuing nursing measures. Neurological function recovery, lower limb function, WHO Quality of Life Brief Scale (WHO-QOL-100), complications and nursing satisfaction were observed and compared in the two groups. 【Results】After nursing, the NIH Stroke Scale (NIHSS) of the observation group was lower than that of the control group (P<0.05). The Fugl-Meyer scores of the observation group were higher than those of the control group at one month and three months after nursing (P<0.05). The scores of WHO-QOL-100 scale in the two groups after nursing were higher than those before nursing, and changes in the observation group were higher than those in the control group (P<0.05). The incidence of total complications in the observation group was 11.11% (5/45), which was lower than 31.11% (14/45) in the control group (P<0.05). The nursing satisfaction rate of the observation group was 95.56% (43/45), which was significantly higher than 77.78% (35/45) of the control group (P<0.05). 【Conclusion】IMB model combined with continuing nursing is beneficial to the recoveries of nerve and lower limb function, reduces complications and improves the quality of life in patients with cerebral infarction bridging surgery. It is worthy of clinical application. 2019 Vol. 36 (4): 637-639 [Abstract] ( 83 ) HTML (1 KB)  PDF  (0 KB)  ( 16 ) 640 Effects of Zoledronic Acid on the Expression of VEGF-C and COX2 in Patients with Advanced Non-small Cell Lung Cancer WANG Wei DOI: 10.3969/j.issn.1671-7171.2019.04.006 【Objective】To investigate the clinical effects of zoledronic acid in patients with advanced non-small cell lung cancer(NSCLC) and its effects on the levels of vascular endothelial growth factor C (VEGF-C) and cyclooxygenase 2 (COX2). 【Methods】Sixty-eight patients with advanced NSCLC cancer with bone metastases were divided into two groups (n=34 in each group). Patients in the control group received routine TP chemotherapy, while patients in the observation group received zoledronic acid in addition to TP chemotherapy. The clinical effects were compared between the two groups. The expression levels of VEGF-C, COX2 , BLAP (the specific sequence of bone alkaline phosphatase) , PINP (type I procollagen N-terminal propeptide) β -CTX (type I collagen carboxy terminal peptide β) and β-crosslaps before and after treatment were also compared between the two groups. 【Results】The therapeutic effect rate of the observation group was 94.12% (32/34), which was higher than that of the control group (79.41%, 27/34) (P<0.05). The levels of BLAP, PINP, β-CTX, β-crosslaps, VEGF-C and COX2 in the observation group were lower than those in the control group(P<0.05). The incidence of rash, muscle , joint pain, myelosuppression, arrhythmia, kidney dysfunction, headache and fever in both groups was not statistically significant difference (P>0.05). 【Conclusion】The use of zoledronic acid in patients with advanced NSCLC bone metastasis can improve the biochemical markers of bone turnover, reduce the levels of VEGF-C and COX2, and have high drug safety. It is worthy of popularization and application. 2019 Vol. 36 (4): 640-642 [Abstract] ( 106 ) HTML (1 KB)  PDF  (0 KB)  ( 14 ) 643 Comparison of Effective Ventilation Volume, Blood Oxygen Concentration and Sleep and Quality of Life in Patients with Simple Snoring and Obstructive Sleep Apnea Hypopnea Syndrome during Sleep GAO Qian, JIANG Lin-lin, WANG Li-yan, et al DOI: 10.3969/j.issn.1671-7171.2019.04.007 【Objective】To investigate the effective ventilation volume, blood oxygen concentration, sleep and quality of life in patients with simple snoring and obstructive sleep apnea hypopnea syndrome (OSAS) during sleep. 【Methods】From January 2017 to May 2018, 50 patients with obstructive SAHS (group A), 50 patients with simple snoring (group B) and 50 healthy people (group C) were randomly selected. AHI, SaO2 and sleep quality during sleep were compared among the three groups. The quality of life of the group A and the group B was assessed by Calgary Quality of Life Scale and compared. 【Results】The AHI of the group A, the group B and the group C increased in turn, and the SaO2 decreased in turn, with significant difference between groups (P<0.05). Shallow sleep was dominant in the group A and the group B, while deep sleep was dominant in the group C, and the proportion of shallow sleep in the group A was significantly higher than that in the group B. The scores of daily activities, social interaction, emotions and symptoms in the group A were significantly lower than those in the group B, with significant difference (P<0.05). 【Conclusion】The patients with obstructive SAHS had higher AHI and lower SaO2, mainly with shallow sleep and lower quality of life. 2019 Vol. 36 (4): 643-644 [Abstract] ( 108 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 645 Study on Relationship between Corneal Shaping Effect and Myopia Correction after Wearing Corneal Plasticizer LUO Chao, LU Qiang, CAI Li-feng DOI: 10.3969/j.issn.1671-7171.2019.04.008 【Objective】 To explore the relationship between corneal shaping effect and the amount of myopia correction after wearing corneal plasticizer. 【Methods】A total of 500 cases of myopia were selected from January 2014 to January 2018 in our Hospital. Corneal plastic effects (ocular refraction, central corneal thickness, corneal curvature) and naked eye vision were measured before and after wearing glasses for 7 days, 3 months and 6 months. The relationship between corneal shaping effect and myopia correction was analyzed. 【Results】After 7 days, 3 months and 6 months of wearing glasses, the diopter, central corneal thickness and corneal curvature of myopia patients were significantly lower than those before wearing glasses. The visual acuity of naked eye was significantly higher than that before wearing glasses(P<0.05). There was no significant difference between the indexes of 3 months and 6 months after wearing glasses (P>0.05). Pearson correlation analysis showed that ocular diopter, central corneal thickness and corneal curvature were positively correlated with the increase of visual acuity of naked eye (P<0.05). 【Conclusion】The corneal shaping effect of myopic patients after orthokeratology is related to the amount of myopia correction. Eye refraction/diopter, central corneal thickness and corneal curvature can be used as important indicators to evaluate the effect of corneal shaping. 2019 Vol. 36 (4): 645-647 [Abstract] ( 70 ) HTML (1 KB)  PDF  (0 KB)  ( 20 ) 648 Observation on the Curative Effect of Kuntai Capsule Combined with Fenmotong(complex packing estradiol) in the Treatment of Perimenopausal Syndrome FU Li-Xia DOI: 10.3969/j.issn.1671-7171.2019.04.009 【Objective】To investigate the effect of Kuntai capsule combined with complex packing estradiol(Fenmotong) in the treatment of perimenopausal syndrome.【Methods】A total of 146 perimenopausal patients who were treated in our hospital from October 2016 to October 2017 were randomly divided into control group and observation group. Each group had 73 cases. The control group was given complex packing estradiol cycle sequential treatment. The observation group was given Kuntai Capsule on the basis of the control group. The clinical efficacy, ovarian function, quality of life and adverse drug reactions before and after treatment were compared between the two groups.【Results】There was no significant difference in FSH, AFC, LH, E2, MENQOL and clinical symptom score between the two groups before treatment (P>0.05); after treatment, the improvement effect of FSH, AFC, LH and E2 in the observation group was significantly higher than that in the control group (P<0.05); the clinical symptom score and ENQOL score in the observation group were significantly lower than those in the control group (P<0.05). In the control group (P<0.05), the total effective rate in the observation group was significantly higher than that in the control group (P<0.05); there was no significant difference in the incidence of side effects between the two groups (P>0.05). 【Conclusion】Kuntai capsule combined with Fenmotong in the treatment of perimenopausal syndrome can improve the clinical symptoms and ovarian function of patients, improve the clinical efficacy and quality of life, and is relatively safe, which is worthy of clinical application. 2019 Vol. 36 (4): 648-650 [Abstract] ( 141 ) HTML (1 KB)  PDF  (0 KB)  ( 20 ) 651 Clinical Efficacy of Nasojejunal Nutrition Tube Combined with Tailored Enterostomy in the Treatment of Neonatal High Jejunal Atresia WANG Jian-jun, WU Kai, HE Ji-xian, et al DOI: 10.3969/j.issn.1671-7171.2019.04.010 【Objective】To investigate the clinical effect of transnasal jejunal nutrition tube combined with tailored enterostomy in the treatment of neonatal high jejunal atresia.【Methods】The clinical data of 42 children with high jejunal atresia admitted to the Department of Neonatology, Zhujiang Hospital, Southern Medical University from January 2010 to December 2018 were retrospectively analyzed. According to the different surgical methods, they were divided into control group (intestinal anastomosis,n=20) and observation group (nasojejunal nutrition tube combined with tailored enterostomy,n=22). The incidence of complications, hospital stay, the first feeding time after operation and the total feeding time after operation were compared between the two groups.【Results】 There was no anastomotic leakage in the observation group and 1 case of intestinal obstruction after operation. On the 14th day after operation, intestinal adhesiolysis was performed. Postoperative recovery was good. In the control group, 2 cases had anastomotic leakage and 4 cases had intestinal obstruction after operation. There were significant differences in the cure rate, complication rate and mortality between the two groups (P<0.05). The first feeding time, total feeding time and hospitalization time in the observation group were significantly lower than those in the control group (P<0.05). 【Conclusion】Transnasojejunal nutrition tube combined with tailored jejunostomy can improve the surgical effect of congenital high jejunal atresia, shorten the hospital stay, reduce the complications of anastomotic leakage and intestinal obstruction after operation, and is an ideal surgical method for the treatment of congenital high jejunal atresia. 2019 Vol. 36 (4): 651-654 [Abstract] ( 75 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 655 Effect of Family Contract on Rehabilitation of Stroke Patients HE Min-lan, CHEN Yin-juan, YANG Hong-yu, et al DOI: 10.3969/j.issn.1671-7171.2019.04.011 【Objective】To explore the effect of family contract on rehabilitation of stroke patients. 【Methods】A total of 200 patients 200 patients with stroke sequelae admitted to our hospital from July 2017 to December 2018 were randomly divided into observation group and control group with 100 cases in each group. The patients in the control group received routine community rehabilitation intervention after discharge, while the patients in the observation group received rehabilitation intervention through the contracted services of community family doctors. After 3 months, 6 months and 9 months of intervention, the patients'ability to live completely independently was assessed by modified Rankin Scale (MRS), and the self-perceived Burden Scale (SPBS) was used to measure the patients' self-perceived burden. Family function scale (APGAR) was used to assess the family function of patients, 60s sit-and-stand (STS-60) were used to assess muscle endurance, and 5s sit-and-stand (STS-5) were used to assess muscle strength.【Results】 Before and 3 months after intervention, there was no significant difference in the scores between the two groups (P>0.05). After 6 months and 9 months of intervention, the MRS and SPB scores of the two groups were significantly lower than those before intervention (P<0.05), APGAR scores were significantly higher than those before intervention (P<0.05), and the MRS and SPB scores of the observation group were significantly lower than those of the control group (P<0.05), APGAR scores were significantly lower than those of the control group (P<0.05). It was significantly higher than that of the control group (P<0.05). Before intervention, there was no significant difference in STS-60 and STS-5 between the two groups (P>0.05); after 3 months, 6 months and 9 months of intervention, STS-60 in the two groups increased gradually (P<0.05), and that in the observation group was significantly higher than that in the control group (P<0.05), while that in the two groups decreased gradually (P<0.05), and that in the observation group was significantly lower than that in the control group (P<0.05).【Conclusion】 Community implementation of family contract has obvious effect on rehabilitation of stroke patients. It has obvious effect on improving patients'ability to live independently, exercise, family function and reducing their burden of self-feeling. With the passage of time, the effect of intervention becomes more obvious, and it is suitable for popularization and application. 2019 Vol. 36 (4): 655-656 [Abstract] ( 63 ) HTML (1 KB)  PDF  (0 KB)  ( 15 ) 657 Effect of Structural Psychological Nursing on Stress Response and Sleep Quality of Emergency Observant Patients ZHAI Chun-xia, ZHANG Li DOI: 10.3969/j.issn.1671-7171.2019.04.012 【Objective】To investigate the effects of structured psychological nursing on psychological stress response and sleep quality in emergency patients. 【Methods】A total of 112 patients in the emergency department from January 2018 to June 2018 were enrolled in the study. They were randomly divided into the treatment group and the control group. The control group was given routine nursing intervention including life weight monitoring, therapeutic nursing, general psychological nursing, etc., while the treatment group combined with structural psychological nursing intervention. The psychological stress response and sleep quality of the two groups of emergency patients were compared. 【Results】The emotional response and physical response scores of the treatment group were significantly lower than those of the control group, and the behavioral response score was significantly higher than that of the control group (P<0.05); The main sleep quality, sleep time, sleep efficiency, sleep disturbance, and daytime dysfunction scores were significantly lower than the control group (P<0.05). 【Conclusion】Structural psychological nursing can help alleviate the emotional response and physical response of patients in emergency department, promote behavioral changes and improve the quality of sleep. 2019 Vol. 36 (4): 657-659 [Abstract] ( 80 ) HTML (1 KB)  PDF  (0 KB)  ( 14 ) 660 Diagnostic value of ultrasonography for benign and malignant Hashimoto's thyroiditis a Meta analysis PENG Kai, ZHOU Ping DOI: 10.3969/j.issn.1671-7171.2019.04.013 【Objective】To analyze the value of ultrasonography in the diagnosis of benign and malignant nodules of Hashimoto's thyroiditis. 【Methods】Using ultrasound, Hashimoto's thyroiditis, benign and malignant nodules as the key words, the Chinese and English medical databases in the past 10 years were searched, and the related literatures were obtained, and the titles and abstracts of the literatures were extracted. According to the research literature screening criteria, the obtained literature was screened, and the research literature was selected as the research data. Revman 5.3 software was used for Meta analysis. Analyze and summarize the results and summarize them. 【Results】a total of 168 articles were obtained from the study, and 14 were selected as research materials, and the rate of literature selection was 8.3%. There are 8 high-quality literature and 6 low quality papers. Meta-analysis of diagnostic accuracy showed OR = 2.84, 95% CI[2.03, 3.98], overall effect test Z = 5.36, P<0.01, diamond on the right side of the middle line; diagnostic compliance Meta-analysis showed OR = 4.17, 95% CI[2.08, 8.34], overall effect test Z = 5.86, P<0.01. The diamond shape was on the right side of the middle line, and the missed diagnosis rate was OR=0.39, 95% CI[0.19, 0.77], and the overall effect test Z=5.26, P<0.01. The diamond shape was located on the left side of the middle line, and the sensitivity Meta analysis result was OR = 2.14, 95% CI [1.09, 4.18], and the overall effect test Z = 5.48, P<0.01. Diamond is located on the right side of the middle line. 【Conclusion】Ultrasound in the diagnosis of benign and malignant nodules of Hashimoto's thyroiditis has the advantages of high accuracy, low missed diagnosis rate, high sensitivity and high compliance rate, so it has the value of application and promotion. 2019 Vol. 36 (4): 660-663 [Abstract] ( 95 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 664 Changes in Serum CgA, Leptin and Adiponectin Levels and Correlation with Cardiac Function in Chronic Heart Failure Patients DING Wei, CHEN Wen-zhong DOI: 10.3969/j.issn.1671-7171.2019.04.014 【Objective】To investigate the changes of serum chromogranin (CgA), leptin and adiponectin (ADPN) in patients with chronic heart failure (CHF) and their relationship with cardiac function. 【Methods】A total of 110 patients with CHF (the CHF group) and 110 healthy subjects (the control group) were enrolled in our hospital from April 2016 to September 2017. Serum CgA, leptin and adiponectin levels were measured in all patients of the two groups. The New York Heart Association (NYHA) grading standards were used to analyze the correlation between serum CgA, leptin and adiponectin levels and cardiac function indicators. 【Results】Serum levels of CgA, leptin and adiponectin were significantly higher in the CHF group than in the control group (P<0.05). The LVEF of the CHF group was lower than that of the control group (P<0.05). The values of LVEDD, LAD, RVD and LVMI were higher than those of the control group (P<0.05). The levels of serum CgA, leptin and ADPN in NYHA class Ⅱ,Ⅲ and Ⅳ patients with CHF were gradually increased, and the differences were statistically significant (P<0.05). Serum levels of CgA, leptin and ADPN in the CHF group were significantly negatively correlated with LVEF (rCgA=-0.721, rleptin=-0.693,rADPN=-0.580, both P<0.05).【Conclusion】The levels of serum CgA, leptin and adiponectin in patients with CHF increase significantly and show negative correlation with LVEF indicating the deterioration of cardiac function in patients. 2019 Vol. 36 (4): 664-666 [Abstract] ( 72 ) HTML (1 KB)  PDF  (0 KB)  ( 15 ) 667 Clinical Observation of Xiaoshui Decoction in the Treatment of Communicating Hydrocephalus after Spontaneous Subarachnoid Hemorrhage MA Xiao-zhen, WANG De-liang, ZHANG Guo-qing DOI: 10.3969/j.issn.1671-7171.2019.04.015 【Objective】To explore the clinical effect of Xiaoshui Decoction on communicating hydrocephalus (aSAH-CHP) after spontaneous subarachnoid hemorrhage. 【Methods】From October 2016 to August 2018, 60 patients with aSAH-CHP admitted to the Department of Neurosurgery, Affiliated Hospital of Shandong University of Traditional Chinese Medicine and Neurosurgery, Weifang Hospital of Traditional Chinese Medicine were randomly divided into observation group and control group with 30 cases in each group. Patients in the control group were given conventional western medicine treatment, while patients in the observation group were given Xiaoshui drink on the basis of the same treatment in the control group. Two groups of patients were treated for 6 courses, followed by 3 months of observation and follow-up. After the end of the clinical study, we observed and recorded the improvement of clinical symptoms of TCM, the change of neurological deficit score, the disappearance of hydrocephalus and the adverse reactions during the medication.【Results】The effective rate of the observation group was 83.3% (25/30) significantly higher than that of the control group (56.7%) (17/30), the difference was statistically significant (χ2=-2.180,P=0.029<0.05). After treatment, the scores of main symptoms, secondary symptoms and total symptoms in the two groups were lower than those before treatment, and those in the observation group were lower than those in the control group, the difference was statistically significant (P<0.05). There were 26 cases (86.6%) with Evans index < 0.3 in the observation group and 24 cases (80.0%) in the control group. There was no significant difference in the disappearance rate of hydrocephalus between the two groups (P>0.05); 2 cases of diarrhea and 1 case of electrolyte abnormality in the observation group; 2 cases of abnormal liver and kidney function and 2 cases of electrolyte disturbance in the control group. There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).【Conclusion】On the basis of Western medicine, Xiaoshui Decoction can reduce the scores of TCM symptoms and improve clinical symptoms in patients with aSAH-CHP. 2019 Vol. 36 (4): 667-669 [Abstract] ( 79 ) HTML (1 KB)  PDF  (0 KB)  ( 15 ) 670 Effect of Remifentanil Combined with Sevoflurane on Anesthesia and Hemodynamics in Patients Undergoing Laparoscopic Cholecystectomy DONG Xiang, CHENG Yun-kun, XU Jing, et al DOI: 10.3969/j.issn.1671-7171.2019.04.016 【Objective】To explore the effect of remifentanil combined with sevoflurane on general anesthesia and hemodynamics in patients undergoing laparoscopic cholecystectomy(LC). 【Methods】A total of 80 patients with LC were randomly divided into two groups. Patients of the control group received the sufentanil, propofol and rocuronium bromide, while patients of the observation group received sevoflurane combined with remifentanil. The time of consciousness disappearance and awakening of the two groups were counted. MAP and HR of the two groups were recorded at the beginning of anesthesia (T1), 5 minutes after anesthesia (T2), the beginning of surgery (T3) and the end of surgery (T4). The adverse reactions were recorded in detail. 【Results】The duration of consciousness disappearance and awakening in the observation group was significantly shorter than in the control group (P＜0.01).At T1, there was no difference in MAP and HR between the two groups (P>0.05). During the whole anesthesia, the MAP and HR of the two groups showed high level at T1 and T3, while lower level at T2 and T4. At T2, T3 and T4, MAP and HR of the observation group were lower than those of the control group (P＜0.05). MAP and HR of the two groups showed high level in T1 and T3, low level in T2 and T4. The incidence of adverse reactions such as dizziness, lethargy, nausea/vomiting, agitation and respiratory depression in the observation group was significantly lower than that in the control group (P＜0.05). 【Conclusion】Remifentanil combined with sevoflurane is effective in anesthesia for LC surgery, which can obviously shorten the time of consciousness disappearing and awakening procedure, stabilize intraoperative hemodynamic and vital signs in patients, and has less drug adverse reaction. It is worthy of clinical application. 2019 Vol. 36 (4): 670-671 [Abstract] ( 73 ) HTML (1 KB)  PDF  (0 KB)  ( 15 ) 672 Clinical Efficacy of Biomimetic Electrical Stimulation Combined with Artificial Cycle Therapy in Moderate to Severe Intrauterine Adhesions WU, Fei, LUO, Jun, LONG, Ting, et al DOI: 10.3969/j.issn.1671-7171.2019.04.017 【Objective】To investigate the clinical efficacy of biomimetic electrical stimulation combined with artificial cycle therapy in the treatment of moderate to severe intrauterine adhesions (IUA). 【Methods】 In our hospital, 98 patients with moderate to severe IUA underwent hysteroscopic intrauterine adhesions (TCRA) were randomly divided into the study group (n=47) and the control group (n=51). The patients in the study group were treated with biomimetic electrical stimulation and artificial cycle therapy after TCRA, while patients in the control group were only treated with artificial cycle therapy after TCRA. The situation of menstruation, recovery of postoperative uterine cavity shape, B-ultrasound ovulation thickness of endometrium and uterine artery blood flow resistance index (RI) were recorded and compared in two groups before and after treatment. 【Results】After treatment,the menstrual improvement rate of the study group was 89.36% (42/47), which was better than that of the control group (70.59%, 36/51) (P<0.05). In the study group, the uterine cavity shape recovered better and the proportion of post-treatment adhesions that needed separation again was smaller compared to the control group (P<0.05). The difference between the two groups was statistically significant (P<0.05). The ovulation endometrial thickness of the study group increased more significantly than that of the control group (P<0.05). The uterine artery blood flow resistance after treatment decreased more in the study group than in the control group. The difference between the two groups was statistically significant (P<0.05). 【Conclusion】Biomimetic electrical stimulation combined with artificial cycle therapy can effectively improve the pelvic blood circulation and promote endometrial growth.This combined application brings better therapeutic effect than hormone treatment alone in moderate to severe IUA . 2019 Vol. 36 (4): 672-674 [Abstract] ( 79 ) HTML (1 KB)  PDF  (0 KB)  ( 19 ) 675 Clinical Study on Minimally Invasive Treatment of Hypertensive Intracerebral Hemorrhage by Improved Stereotaxy Plus Intraoperative B-mode Ultrasonography WANG Bo, WEI Ming-jiong, HUI Yi-ming, et al DOI: 10.3969/j.issn.1671-7171.2019.04.018 【Objective】 To explore the clinical effect of CT modified stereotactic plus intraoperative B-ultrasonography precise localization and minimally invasive treatment of hypertensive intracerebral hemorrhage.【Methods】The clinical data of 82 patients with hypertensive intracerebral hemorrhage admitted to the Second People's Hospital of Shaanxi Province from June 2013 to February 2017 were retrospectively analyzed. According to the different treatment methods, they were divided into craniotomy group (routine craniotomy, n=40) and minimally invasive group (CT modified stereotactic + intraoperative B-ultrasonography precise positioning minimally invasive hematoma clearance treatment, n=42). The clinical efficacy, Glasgow Prognosis Scale (GOS), Coma Score (GCS), Neurological Deficiency (NIHSS), Barthel Index of Living Ability were compared between the two groups. The clearance of hematoma and the rate of rebleeding were recorded.【Results】There was no significant difference in operation time and hematoma clearance rate between the two groups (P>0.05); the amount of bleeding, hospitalization time and rebleeding rate in the minimally invasive group were lower than those in the craniotomy group (P<0.05). The effective rate of minimally invasive group was 83.33% (35/42) higher than that of craniotomy group (70.00% (28/40), and the difference was statistically significant (χ2= 5.543, P=0.028<0.05). The GOS score of the two groups was good, moderate disability, severe disability, plant survival and death. The minimally invasive group was better than the craniotomy group (Z=-0.344, P<0.05). After treatment, GCS score and Barthel index increased and NIHSS score decreased in both groups, and the minimally invasive group was better than the craniotomy group (P<0.05).【Conclusion】CT modified stereotactic plus intraoperative B-ultrasonography precise localization minimally invasive treatment of hypertensive intracerebral hemorrhage has better clinical efficacy, postoperative neurological function, life ability improvement, and can reduce the risk of re-bleeding, with less bleeding, short hospitalization time and other advantages. 2019 Vol. 36 (4): 675-677 [Abstract] ( 69 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 678 Pathogen and Drug Resistance of Leukemia Patients after Chemotherapy in Hospital YU Guang-qiong, LIU Hang, HE Lin-lin, et al DOI: 10.3969/j.issn.1671-7171.2019.04.019 【Objective】To explore the pathogenic distribution with bloodstream infection and post-chemotherapy drug resistance in patients with leukemia. 【Methods】Retrospective analysis of the clinical data of 325 leukemia patients with blood stream infection after chemotherapy was conducted to investigate the distribution of pathogenic bacteria and drug resistance of blood stream infection. 【Results】Among the 350 pathogenic strains we checked, 100 were Gram-positive bacteria (G+)( 28.57%), 245 were Gram-negative bacteria (G-)(70.0%)and 5 were fungi(1.43%). The isolated pathogens were mainly Klebsiella pneumoniae (21.14%), Escherichia coli (20.57%), coagulase-negative staphylococci (17.71%), Pseudomonas aeruginosa (14.29%) and golden yellow Staphylococcus (4.86%). Escherichia coli and Klebsiella pneumoniae isolated from Gram-negative bacteria (G-), which produced the extended-spectrum β-lactamase, were more resistant to antibiotics than non-ESBLs strains. Enterobacteriaceae (intestinal bacilli) were less resistant to carbapenem drugs, tigecycline, and piperacillin (less than 14%). The resistance rates of Acinetobacter baumannii to cefotaxime and cefixime were both 7.0%, and their resistance rates to cefoxitin and cefazolin were both higher than 50.0%. In addition, they were sensitive to tigecycline. The resistance rate of Pseudomonas aeruginosa to various antimicrobial agents was below 12.0%. We did not detect any resistance to linezolid, vancomycin and tigecycline in Gram-positive bacteria (G+). 【Conclusion】 There are a variety of types of pathogenic bloodstream infections in leukemia patients after chemotherapy. Gram-negative bacteria (G-) are the main stains, which have more serious drug resistance. Linezolid, vancomycin and tigecycline can be applied to the treatment of Gram-positive bacteria (G+) bloodstream infections. 2019 Vol. 36 (4): 678-680 [Abstract] ( 93 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 681 Clinical Analysis of Loop Electrosurgical Excision Procedure Combined with Interferon Suppository in the Treatment of Cervical Intraepithelial Neoplasia LIANG Liang, ZANXIA La-mu, SILANG Qing-cuo DOI: 10.3969/j.issn.1671-7171.2019.04.020 【Objective】To investigate the clinical efficacy of loop electrosurgical excision procedure (LEEP) combined with interferon suppository in the treatment of cervical intraepithelial neoplasia (CIN). 【Methods】Eighty-two cases of cervical intraepithelial neoplasia treated in our hospital from April 2014 to April 2017 were randomly divided into two groups: the observation group and the control group. The patients in the control group were treated with LEEP, and the patients in the observation group were treated interferon suppository before and after LEEP. The clinical efficacy, intraoperative and postoperative immune function indexes, and 1-year postoperative recurrence rate were compared between the two groups.【Results】The cure rate of the observation group was 95.12% ,which was significantly higher than that of the control group 73.17% (P<0.05). Compared to the control group, the intraoperative bleeding volume, wound healing time, vaginal bleeding time and vaginal discharge time were significantly shortened in the observation group (P<0.05). Before treatment, there was no significant difference in immune function between the two groups. After treatment, the levels of IgA,IgG and IgM in the observation group were higher than that those before treatment, while the levels of IgA,IgG and IgM in the control group were lower than those before treatment (P<0.05). After treatment, the levels of IgA,IgG and IgM level in the observation group were higher than those in the control group (P<0.05). The recurrence rate in the observation group was 2.44%, which was significantly lower than that in the control group (12.2%) (P<0.05). 【Conclusion】The combination of LEEP and interferon in the treatment of cervical intraepithelial neoplasia can effectively improve the clinical curative effect, improve the immune function of the patient and reduce the postoperative recurrence rate, which is worthy of clinical popularization. 2019 Vol. 36 (4): 681-683 [Abstract] ( 73 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 684 Study on Cognitive Impairment and Influencing Factors in Patients with Sleep Disorders and Depression GU Hai-ping, SUN Ya-ming DOI: 10.3969/j.issn.1671-7171.2019.04.021 【Objective】To investigate the cognitive impairment and influencing factors in patients with sleep disorders and depression. 【Methods】A total of 160 patients with sleep disorders in our hospital from November 2014 to September 2016 were enrolled in this study. Among them, 60 patients with depression were treated as group A and 100 patients with simple sleep disorder as group B. Tests with repetitive neuropsychological status (RBANS) were used to evaluate the cognitive function of the two groups. The factors related to the cognitive impairment were explored by multivariate regression analysis method. 【Results】 The immediate memory, breadth of vision, speech function, attention, time- delayed memory and the total score of RBANS in group A were significantly lower than those in group B. the differences were statistically significant (P<0.05). The detection rate of cognitive impairment in group A was 46.67% (28/60), which was significantly higher than that in group B 7%(7/100). The difference was statistically significant (P<0.05). Carotid stenosis, prolonged course of sleep disorders and depression were independent risk factors for cognitive dysfunction in patients with sleep disorders (OR=2.296, OR=1.574, OR=1.309,P<0.05). 【Conclusion】Carotid stenosis, prolonged course of sleep disorders and depression are independent risk factors for cognitive dysfunction in patients with sleep disorders. Sleep disorders associated with depression will further increase the cognitive impairment of patients, so we must pay attention to the treatment of patients with depression. 2019 Vol. 36 (4): 684-686 [Abstract] ( 75 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 687 Clinical Characteristics of Intracranial Infection after Posterior Fossa Surgery WANG Liang, LIU Nan, GAO Ben-lin DOI: 10.3969/j.issn.1671-7171.2019.04.022 【Objective】To investigate th ors after surgical treatment.【Methods】The clinical data of 191 patients with posterior fossa tumors from January 2008 to January 2018 were retrospectively analyzed. 25 patients (13.09%) with intracranial infection after operation were monitored and recorded, including body temperature, C-reactive protein (CRP), peripheral blood leukocyte count (WBC), CSF examination results, serum procalcitonin (PCT), and the results of peak and first CSF examination, biochemical indicators, lumbar puncture time were compared.January 2018 were selected. Postoperative intracranial infection in 25 (13.09%)patients. The clinical symptoms and signs of patients with intracranial infection were monitored and recorded, including body temperature, C reactive protein, peripheral blood leukocyte count, CSF test results, serum procalcitonin monitoring. The peak time, the first CSF test results, biochemical indicators, lumbar puncture time were compared (continuous CSF examination of the highest number of nuclear cells in the time that is the peak number of CSF nucleated cells, if the first time the number of CSF patients with the highest nuclear cells, then according to the patient first time). The therapeutic effect and treatment time of the two groups were compared. The results of CSF culture were analyzed. 【Results】All the patients with intracranial infection had fever symptoms of varying degrees. The fever time after operation was (6.21±72) d, WBC was (14.32 ±4.78)×109/L , body temperature was (38.17±0.42)℃, CRP was (28.54±14.34) mg/L, PCT was (2.44±0.45) ng/mL. The above indexes were significantly increased [CRP<10 mg/L, WBC(4~10)×109/L, PCT<0.5 ng/mL was normal]. The infection control time was (15.58±4.89) days. The number of nucleated cells and protein content of CSF in peak period were significantly higher than those in the first time, and the chloride content in peak period was lower than that in the first time (P<0.05). CSF culture results showed that 5 cases were positive (20.00%). Four of them were gram-negative bacteria, including Streptococcus mitigatus, Staphylococcus hemolyticus, Moraxella Oslo, Acinetobacter baumannii complex, Escherichia coli and Pseudomonas sp. Two different strains of bacteria were cultured by CSF in one case, they were Streptococcus mitigatus (G+) and Escherichia coli (G-).【Conclusion】The early clinical characteristics of intracranial infection in patients with posterior cranial fossa tumors after surgical treatment are not specific. The CSF culture of patients has a low positive rate. After surgical treatment, patients suspected of intracranial infection should be examined by CSF many times. Anti-gram-negative drugs should be used empirically as soon as possible. 2019 Vol. 36 (4): 687-688 [Abstract] ( 68 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 689 Expression and Significance of Integrin α 5 and caspase 3 in Hepatocellular Carcinoma LIU Wen-ping DOI: 10.3969/j.issn.1671-7171.2019.04.023 【Objective】 To observe and analyze the expression and clinical significance of integrin α 5 and aspartate protease 3 containing cysteine (caspase 3) in patients with hepatocellular carcinoma(HCC). 【Methods】 Paraffin-embedded specimens of 40 HCC cancer and paracancerous tissues from January to December 2015 underwent surgical resection in our hospital HCC were collected. Immunohistochemical examination of integrin α 5 and caspase 3 expression was performed. Also, fresh HCC tissues and corresponding paracancerous tissues were collected from 30 HCC patients who underwent surgical resection between January to December, 2016. Fluorescence quantitative RT-PCR and Western blotting were used to detect integrin α 5 and caspase 3 expression.【Results】The expression rate of integrin α 5 in HCC was significantly higher than that in adjacent tissues, while the expression of caspase 3 in HCC was lower than that in paracancerous tissue (P<0.05). The expression of integrin α 5 protein in 40 patients with HCC was closely related to TNM stage and tumor metastasis (P<0.05), while caspase 3 protein expression was related to HBsAg,TNM stage and tumor metastasis (P<0.05). There was a negative correlation between integrin α 5 and caspase 3 expression in HCC (P<0.05). The relative expression of integrin α 5 mRNA in HCC was significantly higher than that in adjacent tissues.The caspase 3 mRNA in the liver cancerous tissue was significantly lower than that in the paracancerous tissue (P<0.05). 【Conclusion】The negative correlation between integrin α 5 and caspase 3 may be involved in the apoptosis of hepatoma cells. However, the mechanism of integrin α 5 on apoptosis of hepatoma cells requires further study. 2019 Vol. 36 (4): 689-692 [Abstract] ( 75 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 693 Analysis of Correlation between NT-proBNP and UA Levels and Cardiac Function Classification and Prognosis in Patients with Chronic Heart Failure ZENG Lei, LIU Zhi-hong DOI: 10.3969/j.issn.1671-7171.2019.04.024 【Objective】To study the correlation of cardiac function classification and prognosis with the level of NT-proBNP and uric acid of elderly patients with chronic heart failure. 【Methods】The clinical data of 70 elderly patients with chronic heart failure admitted to our hospital from October 2016 to August 2017 were selected. The serum NT-proBNP and UA levels of patients with different cardiac function grades and prognosis were compared, and the correlation was analyzed. The ROC curve was drawn to obtain the predictive value and cut-off value of the observation indicators for prognosis. 【Results】Serum NT-proBNP and UA levels increased with the increase of cardiac function classification, and there was a significant difference between the two groups (P<0.05). The correlation analysis showed that NT-proBNP and UA levels were positively correlated with cardiac function classification (rNT-proBNP=0.143, P=0.006<0.05; rUA=0.115,P=0.026<0.05). After treatment, the levels of NT-proBNP and UA in the poor prognosis group and the good prognosis group were significantly lower than those before treatment, while the levels of NT-proBNP and UA in the poor prognosis group were significantly higher than those in the good prognosis group before and after treatment, with statistical significance (P<0.05). The ROC curve of NT-proBNP predicting poor prognosis showed that the sensitivity and specificity were the highest when NT-proBNP level was 10 850 pg/mL, 73.4% and 72.0% respectively. The ROC curve of UA predicting poor prognosis showed that the sensitivity and specificity were the highest(60.3% and 64.1% respectively) when UA was 436.4 umol/L. 【Conclusion】The higher the grade of cardiac function in elderly patients with chronic heart failure, the higher the serum NT-proBNP and UA levels, the worse the prognosis of patients. Both of them have certain guiding role in judging the prognosis of patients. 2019 Vol. 36 (4): 693-695 [Abstract] ( 81 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 696 Clinical Study of Nedaplatin Combined with Recombinant Human Vascular Endostatin Hyperthermia Chemotherapy On the Treatment of Cancerous Ascites HUANG Han-sheng, FU Jun-min, WEN Jian-mei, et al DOI: 10.3969/j.issn.1671-7171.2019.04.025 【Objective】To analyze the clinical application of nedaplatin combined with recombinant human vascular endostatin hyperthermia chemotherapy in the treatment of cancerous ascites. 【Methods】The clinical data of 60 patients with cancerous ascites admitted to our hospital from December 2015 to December 2018 were analyzed. They were divided into two groups with 30 cases each: the control group was treated with nedaplatin hyperthermia chemotherapy and the observation group was treated with nedaplatin combined with recombinant human vascular endostatin hyperthermia chemotherapy. The clinical efficacy of the two groups was analyzed before and after treatment. 【Results】In the observation group, there were 14 cases of complete remission and 13 cases of partial remission. Its total effective rate was 90.00%. In the control group, there were 6 cases of complete remission and 14 cases of partial remission. So, the total effective rate was 66.67%. The difference was statistically significant (χ2=4.812, P=0.028<0.05).There were no significant differences between the two groups in the levels of tumor markers CEA, glycoprotein antigen 19-9 (CA19-9) ,vascular endothelial growth factor (VEGF) and tumor necrosis factor alpha (TNF-α) before treatment (P>0.05). The levels of CEA, CA19-9,VEGF and TNF-α in the observation group were lower than those in the control group (P<0.05).The quality of life (Karnofsky score) in the observation group was 96.67% (29/30), which was significantly higher than that of the control group 73.33% (22/30). The difference was statistically significant (χ2=6.405,P=0.011<0.05). The adverse reactions of the two groups were all in grade Ⅰ~Ⅱ, and the occurrence of adverse reactions in the two groups was not statistically significant (P>0.05). 【Conclusion】Nedaplatin combined with recombinant human vascular endostatin thermal perfusion for the treatment of cancerous ascites has better clinical efficacy, which can reduce the levels of tumor markers, improve patients' quality of life without increasing adverse reactions. 2019 Vol. 36 (4): 696-698 [Abstract] ( 69 ) HTML (1 KB)  PDF  (0 KB)  ( 16 ) 699 Diagnostic Value of Ovarian Vein Tracking Based on Multiplanar Reconstituted CT in Ovarian Origin Tumors YANG Lin-lin, WEI Ming-hua, ZHANG Shu-yi, et al DOI: 10.3969/j.issn.1671-7171.2019.04.026 【Objective】To explore the diagnostic value of ovarian vein tracking based on multiplanar reconstructed CT in identifying ovarian tumors. 【Methods】From March 2015 to March 2017, 116 cases of female pelvic tumors were examined by CT and treated surgically in our hospital. Multiplanar reconstructed CT ovarian vein tracing was used to determine whether the pelvic tumors were ovarian sources. The sensitivity, specificity, positive predictive value and negative predictive value of CT ovarian vein tracing were analyzed. 【Results】There were 141 pelvic tumors in 116 patients, 108 ovarian tumors and 33 non-ovarian tumors. 104 of 108 ovarian tumors were identified as ipsilateral ovarian tumors by CT, 3 unilateral ovarian tumors were identified as bilateral and 1 non-ovarian tumors; 26 of 33 non-ovarian tumors were identified as non-ovarian tumors by CT and 7 as ipsilateral ovarian tumors. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of CT in identifying ipsilateral ovarian tumors were 96.3%, 78.8%, 92.2%, 93.7% and 86.7%, respectively.【Conclusion】Ovarian vein tracing based on multi-planar reorganization CT is a simple, accurate and reproducible method for identifying ovarian tumors, which has important clinical application value. 2019 Vol. 36 (4): 699-701 [Abstract] ( 69 ) HTML (1 KB)  PDF  (0 KB)  ( 14 ) 702 Experimental Study on the Relationship between Serum Bone Formation Markers and Longitudinal Bone Growth in Rats JIANG Xiu-fang, CHU Li-min, CHENG Si-si, et al DOI: 10.3969/j.issn.1671-7171.2019.04.027 【Objective】 To investigate the relationship between serum bone formation markers and bone longitudinal growth. 【Methods】Forty-seven clean male SD rats aged 3 weeks were randomly divided into dexamethasone group (27 rats) and control group (20 rats). The rats in the dexamethasone group were intraperitoneally injected with dexamethasone daily, while the rats in the control group were intraperitoneally injected with saline of equal volume for 10 days. The nasal tail length, body weight and tibial length of rats in the two groups were measured. Tibial tissue with growth plate was prepared and the total thickness of growth plate, the thickness of growth plate proliferation zone and the thickness of growth plate hypertrophy zone were measured. The levels of serum bone formation markers [osteocalcin (OC), I collagen carboxyl terminal propeptide (PICP) and alkaline phosphatase (ALP)] were measured by ELISA method in two groups of rats.【Results】The body weight, nasal tail length and tibia length of rats in the dexamethasone group were significantly lower than those in the control group (P<0.05); the thickness of growth plate, proliferative zone and hypertrophic zone of rats in the dexamethasone group were significantly lower than those in the control group (P<0.05); there were no significant differences in serum OC, ALP and PICP levels between the two groups (P>0.05). In the dexamethasone group, serum OC was positively correlated with tibial length and thickness of proliferative zone (P<0.05), serum ALP was negatively correlated with tibial length (P<0.05), and serum PICP was positively correlated with nasal tail length (P<0.05). 【Conclusion】Glucocorticoids can significantly inhibit the longitudinal growth of rat skeleton. OC, ALP and PICP may be potential indicators of the longitudinal growth of rat skeleton. 2019 Vol. 36 (4): 702-704 [Abstract] ( 82 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 705 Clinical Effect of Minimally Invasive FasT-Fix Suture Repair in the Treatment of Knee Meniscus Injury DAI Yan-kun, TANG Jin-shan, XIE Xue-guan, et al DOI: 10.3969/j.issn.1671-7171.2019.04.028 【Objective】To investigate the clinical effect of minimally invasive FasT-Fix suture repair in the treatment of knee meniscus injury. 【Methods】 A total of 72 patients with knee meniscus injury in our hospital from February 2015 to December 2016 were treated with minimally invasive FasT-Fix suture repair was performed. The IKDC and Lysholm scoring systems were used to evaluate the function of knee joint. γ-glutamyltransferase (GGT), alkaline phosphatase (ALP), interleukin -4 (IL-4), IL-8, tumor necrosis factor (TNF-α)and C reactive protein (CRP) before and after treatment were detected. 【Results】The surgery time frame was 17~45min with average surgery time (27.80 ± 6.81) min. The amount of intraoperative blood loss was 5~30 mL with average amount 15.40 ± 6.11 mL. The follow-up time ranged from 9 to 31 months, the average follow-up time was (20.42 ± 6.88) months.The clinical healing rate was 90.28%.The IKDC and Lysholm scores at 1, 3, and 6 months after surgery were significantly improved compared to before surgery (P<0.05).The levels of TNF-α, IL-4, IL-8 and CRP at 3 d and 7 d post-operation did not show significant differences compared to pre-operation (P>0.05). 【Conclusion】Minimally invasive FasT-Fix suture repair for the treatment of knee meniscus injury is effective for better postoperative knee function recovery and less inflammatory response. It is worthy of clinical application. 2019 Vol. 36 (4): 705-706 [Abstract] ( 63 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 707 Changes in Serum NSE and ProGRP in Patients with NSCLC and Their Relationship with Disease Development ZHOU Wei, PAN De-jian, ZHOU Xi-jian, et al DOI: 10.3969/j.issn.1671-7171.2019.04.029 【Objective】To investigate the changes and clinical significance of serum neuron specific enolase (NSE) and gastrin releasing peptide precursor fragment 31-98 (ProGRP) in non-small cell lung cancer (NSCLC) . 【Methods】A total of 90 patients with NSCLC in our hospital from January 2017 to September 2017 were enrolled in the NSCLC group and 90 healthy subjects were recruited in the control group. Serum NSE and ProGRP levels were measured and compared between the two groups. The difference in serum NSE and ProGRP levels in patients with NSCLC who had pleural effusion, lymph node metastasis, different TNM stages, and histological differentiation were analyzed. 【Results】 Serum levels of NSE and ProGRP were significantly higher in the NSCLC group than in the control group (P<0.05). Serum NSE and ProGRP levels in patients with TNM stage Ⅲ~Ⅳ and lymph metastasis were significantly higher than those with TNM stage Ⅰ~Ⅱ and no lymph metastasis The difference was statistically significant (P<0.05). The serum levels of NSE and ProGRP did not show difference in patients with different degrees of NSCLC differentiation and with pleural effusion; the difference was not statistically significant (P>0.05). 【Conclusion】Serum NSE and ProGRP levels were significantly elevated in NSCLC patients, and the increase was more significant in the serum of patients with lymph node metastasis and advanced TNM stage. 2019 Vol. 36 (4): 707-709 [Abstract] ( 73 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 710 Analysis of Correlation between Changes of Blood Lipid Level and Complications and Prognosis after PCI in Patients with Acute Myocardial Infarction WANG Jiao-long, LI Feng, NING Wei DOI: 10.3969/j.issn.1671-7171.2019.04.030 【Objective】To explore the correlation between blood lipid level and complications and prognosis of patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI).【Methods】The clinical data of 150 patients with AMI undergoing PCI from August 2014 to August 2016 were selected and divided into hyperlipidemia group (hyperlipidemia level higher than normal reference standard, n=80) and non-hyperlipidemia group (normal blood lipid level, n=70). The occurrence of complications and the time of first occurrence were recorded. Logistic multivariate analysis was used to analyze the risk factors affecting the occurrence of complications. Spearman correlation coefficient was used to analyze the correlation between blood lipid index and the time of complications. 【Results】Serum total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) levels in hyperlipidemia group were significantly higher than those in non-hyperlipidemia group, and serum high density lipoprotein cholesterol (HDL-C) levels were significantly lower than those in non-hyperlipidemia group (P<0.05). The incidence of stent thrombosis, recurrent myocardial infarction, target vessel restenosis and ischemic stroke in hyperlipidemia group was significantly higher than that in non-hyperlipidemia group (P<0.05). Spearman coefficient correlation analysis showed that TC, TG and LDL-C were negatively correlated with the time of complications (r=-0.589, -0.677, -0.899, all P<0.05), while HDL-C was positively correlated with the time of complications (r=0.869,P<0.05). The disease-free survival curve was drawn by Kaplan-meier method and tested by log-rank method. The results showed that the prognosis of non-hyperlipidemia group was significantly better than that of hyperlipidemia group (χ2=5.014,P=0.025). Logistic multivariate analysis showed that TC and TG were risk factors for the prognosis of patients with AMI (P<0.05).【Conclusion】The incidence of complications in AMI patients with hyperlipidemia treated by PCI is higher than that in non-hyperlipidemia patients, and the level of blood lipid is significantly correlated with the time of complications. TC and TG are the risk factors affecting the prognosis of patients. 2019 Vol. 36 (4): 710-712 [Abstract] ( 114 ) HTML (1 KB)  PDF  (0 KB)  ( 15 )

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