Abstract 【Objective】To investigate the diagnostic value of superior vena cava (SVC) blood flow spectrum parameters in children with pulmonary hypertension (PAH).【Methods】From September 2019 to May 2022, 49 patients with PAH diagnosed by cardiac catheterization in our hospital (PAH group) were selected; In addition, 15 healthy children (control group) who were examined in our hospital at the same time were selected. All subjects were examined by transthoracic echocardiography, collected the SVC blood flow spectrum curve, and evaluated the diagnostic value of SVC blood flow spectrum parameters for PAH using the subject's work characteristic (ROC) curve. 【Results】 The SVC spectrum of the control group showed four phase wave [Systolic concentric wave (S wave), diastolic concentric wave (D wave), late systolic centrifugal wave (VR wave), and atrial late systolic centrifugal wave (AR wave)]; In the PAH group, 44 patients had four phase waves and 5 patients had non four phase waves. The peak velocity of AR wave, the peak velocity of VR wave, and AR/S in the PAH group were significantly higher than those in the control group (P<0.05). The peak velocity of S wave, the peak velocity of D wave, and AR/D, VR/S, VR/D in the two groups had no significant difference (P>0.05). The ROC curve analysis showed that the area under the AR/S curve was 0.812, which was the best for the diagnosis of PAH; When AR/S cut-off value was 0.43, the sensitivity of PAH diagnosis was 68.00%, and the sensitivity of moderate and severe PAH diagnosis was 74.00%. 【Conclusion】 The changes of SVC blood flow spectrum can reflect the changes of PAH. Among them, AR/S has certain diagnostic value for PAH, especially for moderate and severe PAH. When tricuspid regurgitation is not obvious or more ultrasonic support is needed, AR/S can become an effective reference index for clinical diagnosis of PAH in children.
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