硝苯地平控释片与苯磺酸氨氯地平片对清晨高血压患者的降压效果及血压变异性的影响比较

doi:10.3969/j.issn.1671-7171.2026.04.019

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Abstract 【Objective】 To compare the antihypertensive effects and impacts on blood pressure variability between nifedipine controlled-release tablets and amlodipine besylate tablets in patients with morning hypertension. 【Methods】 A total of 109 patients with morning hypertension admitted to our hospital from April 2021 to April 2024 were enrolled and randomly divided into group A (treated with nifedipine controlled-release tablets, n=54) and group B (treated with amlodipine besylate tablets, n=55). Both groups were treated for 12 weeks. The clinical efficacy, incidence of adverse reactions, morning systolic blood pressure (SBP), morning diastolic blood pressure (DBP), morning blood pressure target achievement rate, and blood pressure variability before and after treatment were compared between the two groups. 【Results】 The total effective rates of group A and group B were 96.30% (52/54) and 92.73% (51/55), respectively, with no statistically significant difference (χ²=0.667, P=0.414). At 4, 8, and 12 weeks of treatment, morning DBP and SBP in both groups were lower than those before treatment, and those in group B were lower than group A (P<0.05). There was no significant difference in morning blood pressure target achievement rate between the two groups at 4 and 8 weeks (P>0.05); at 12 weeks, the rate in group B was significantly higher than that in group A (P<0.05). After treatment, systolic blood pressure variability (SBPV) and diastolic blood pressure variability (DBPV) in both groups were significantly lower than those before treatment, and those in group B were significantly lower than group A (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (χ²=0.724, P=0.394). 【Conclusion】 Both nifedipine controlled-release tablets and amlodipine besylate tablets can effectively reduce morning blood pressure, but amlodipine besylate tablets perform better in stabilizing blood pressure, improving the morning blood pressure target achievement rate and reducing blood pressure variability.

Key words： Hypertension Nifedipine Amlodipine Hypotension, Controlled

Received: 09 January 2026

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R544.1

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	LU Ling
	KE Yaqiong
	FAN Linpeng

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LU Ling,KE Yaqiong,FAN Linpeng. Comparison of Antihypertensive Effects and Impacts on Blood Pressure Variability between Nifedipine Controlled-Release Tablets and Amlodipine Besylate Tablets in Patients with Morning Hypertension[J]. JOURNAL OF CLINICAL RESEARCH, 2026, 43(4): 595-598.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2026.04.019 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2026/V43/I4/595

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