血清TLR4、sIL-2R联合HLA-B27水平对不同病原菌感染早产儿预后的预测价值

doi:10.3969/j.issn.1671-7171.2026.04.018

Abstract
Figure/Table
References (0)
Related Citation (15)

Download: PDF (1304 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】 To analyze the predictive value of serum Toll-like receptor 4 (TLR4), soluble interleukin-2 receptor (sIL-2R) combined with human leukocyte antigen B27 (HLA-B27) levels for the prognosis of infection in preterm infants. 【Methods】 A retrospective analysis was conducted on the medical records of 197 premature infants with infections admitted to our hospital from December 2022 to April 2025. Before the treatment, pathogenic bacteria in the infected specimens from all children were identified. The infants were followed up until discharge and they were divided into the good prognosis group (166 cases) and the poor prognosis group (31 cases) according to the prognosis of infection in premature infants. The levels of serum HLA-B27, sIL-2R and TLR4 and the clinical data of the two groups were compared. The influencing factors for poor prognosis of infection in premature infants were assessed; and the predictive values of each detection index for poor prognosis of infection in premature infants were analyzed. 【Results】 A total of 157 pathogenic bacteria were detected in 197 cases of premature infants with infection comprising 93 Gram-negative bacteria and 64 Gram-positive bacteria . Serum TLR4, sIL-2R and HLA-B27 levels in the poor prognosis group were higher than those in the good prognosis group (P<0.05). The length of hospital stay in the poor prognosis group was longer than that in the good prognosis group (P<0.05), and the proportion of newborns with a 5-minute Apgar score of ≤7 in the poor prognosis group was higher than that in the good prognosis group (P<0.05). The ROC curve analysis revealed that the area under the curve (AUC) values of serum TLR4, sIL-2R, HLA-B27 level alone and the combination of the three for predicting poor prognosis of infection in preterm infants were 0.805, 0.846, 0.801, and 0.909 respectively (P<0.05). Moreover, the combined predictive value of these three markers was significantly higher (P<0.05). Logistic regression analysis revealed that serum levels of TLR4 > 404.65 mg/L, sIL-2R > 387.21 ng/L, and HLA-B27 > 99.23 U/mL, as well as a neonatal Apgar score ≤ 7, were independent risk factors for poor prognosis in preterm infants with infection (all P<0.05). 【Conclusion】 The levels of serum TLR4, sIL-2R and HLA-B27 have significant value in predicting the prognosis of infection in premature infants, and the combined predictive value of the three is even higher.

Key words： Infant, Premature Infections Toll-Like Receptor 4 Receptors, Interleukin-2 HLA Antigens Prognosis

Received: 29 December 2025

PACS:

R722

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	GUO Xiaohe
	KANG Yingge
	ZHANG Yuanjing

Cite this article:

GUO Xiaohe,KANG Yingge,ZHANG Yuanjing. Analysis of the Prognostic Value of Serum TLR4, sIL-2R Combined with HLA-B27 Levels in Predicting Infection in Premature Infants[J]. JOURNAL OF CLINICAL RESEARCH, 2026, 43(4): 591-594.

URL:

http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2026.04.018 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2026/V43/I4/591

[1] ZHAO S L, JIANG H M, MIAO Y Q, et al. Factors influencing necrotizing enterocolitis in premature infants in China: a systematic review and meta-analysis[J].BMC Pediatr,2024,24(1):148.
[2] WILKINS D, YUAN Y, CHANG Y, et al. Durability of neutralizing RSV antibodies following nirsevimab administration and elicitation of the natural immune response to RSV infection in infants[J].Nat Med,2023,29(5):1172-1179.
[3] KAWAI T, IKEGAWA M, ORI D, et al. Decoding Toll-like receptors: Recent insights and perspectives in innate immunity[J].Immunity,2024,57(4):649-673.
[4] 王芳,李璐,范超超. 血清超敏C-反应蛋白可溶性肿瘤坏死因子受体-Ⅰ及TOLL样受体4对早产儿早期感染的诊断价值[J].中国妇幼保健,2023,38(4):650-653.
[5] HIRAMI Y, NISHIMURA M F, URATA T, et al. Comparison of serum sIL-2R and LDH levels in patients with intravascular large B-cell lymphoma and patients with advanced stage diffuse large B-cell lymphoma[J].J Clin Exp Hematop,2023,63(1):25-31.
[6] LI Z, KHAN M K, VAN DER LINDEN S M, et al. HLA-B27, axial spondyloarthritis and survival[J].Ann Rheum Dis,2023,82(12):1558-1567.
[7] WEI X F, LIANG J H, ZHANG H, et al. Clinical features and risk factors of Klebsiella pneumoniae infection in premature infants: a retrospective cohort study[J].BMC Infect Dis,2024,24(1):1311.
[8] AKSU B, AFONSO A C, AKIL I, et al. Urine soluble TLR4 levels may contribute to predict urinary tract infection in children: the UTILISE Study[J].Pediatr Nephrol,2024,39(2):483-491.
[9] TANG D M, CAO X X, YUAN B B, et al. Correlation analysis between IL-1R/TLRs pathway and superficial dermatomycosis[J].Eur J Med Res,2025,30(1):191.
[10] 桂冬梅,尹杨艳,陈丹丹,等. 重症儿童感染性休克外周血单个核细胞TLRs信号通路及细胞免疫炎症因子水平变化[J].中华医院感染学杂志,2022,32(23):3648-3652.
[11] WANG W, LIU X, YANG S, et al. Serum levels of soluble interleukin 2 receptor (sIL-2R), tumor necrosis factor-alpha (TNF-alpha), and immunoglobulin M are correlated with the disease extent in childhood Langerhans cell histiocytosis[J].J Cancer Res Clin Oncol,2023,149(13):11431-11442.
[12] 李小伟,刘栩,宫晶,等. CRP/ALB和sIL-2R水平与新生儿肺部感染病情程度及预后的相关性分析[J].中国实验诊断学,2024,28(5):509-514.
[13] WERKL P, RADEMACHER J, PLEYER U. HLA-B27-positive anterior uveitis: Clinical aspects, diagnostics, interdisciplinary management, and treatment[J].Ophthalmologie,2024,121(Suppl 1):12-22.
[14] 刘菁,王宇,汤艳芬,等. 肺结核患者血清HLA-B27和SAA水平表达与病情严重程度及并发肺部其他病原菌感染的相关性研究[J].现代检验医学杂志,2025,40(1):132-137.

[1]	. [J]. JOURNAL OF CLINICAL RESEARCH, 2026, 43(4): 690-692.