FSCN1、hTERT蛋白在卵巢癌组织中的表达及其临床意义

doi:10.3969/j.issn.1671-7171.2026.01.018

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Abstract 【Objective】 To investigate the expression of fascin-1(FSCN1) and human telomerase reverse transcriptase(hTERT) in ovarian cancer and their clinical significance.【Methods】 A total of 44 patients with ovarian cancer were included as the observation group, and 44 patients with benign epithelial ovarian tumors during the same period were selected as the control group. The expression levels of FSCN1 and hTERT proteins in ovarian lesion tissues were compared between the two groups. The correlations between FSCN1 and hTERT expression and clinicopathological characteristics were analyzed in the observation group.【Results】 The high expression rates of FSCN1 and hTERT in the observation group were 70.45% and 72.73%, respectively, which were significantly higher than those in the control group(36.36% and 31.82%, respectively)(P<0.05). In the observation group, FSCN1 and hTERT expression were not associated with age, tumor size, pathological type, or lymph node metastasis(P>0.05), but were related to FIGO stage(P<0.05). Higher FIGO stages were associated with higher expression levels of FSCN1 and hTERT.【Conclusion】 FSCN1 and hTERT are highly expressed in ovarian cancer, and their expression levels are associated with FIGO stage.

Key words： Ovarian Neoplasms Telomerase Gene Expression

Received: 02 September 2025

PACS:

R737.31

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	ZHONG Di
	LI Peng

Cite this article:

ZHONG Di,LI Peng. Expression and Clinical Significance of FSCN1 and hTERT in Ovarian Cancer[J]. JOURNAL OF CLINICAL RESEARCH, 2026, 43(1): 66-68.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2026.01.018 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2026/V43/I1/66

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