透明细胞性肾细胞癌组织中CPEB4的表达变化及其临床意义

doi:10.3969/j.issn.1671-7171.2026.01.017

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Abstract 【Objective】 To investigate the expression of cytoplasmic polyadenylation element binding protein 4(CPEB4) in clear cell renal cell carcinoma(CCRCC) tissues and its clinical significance.【Methods】 Cancer tissues and adjacent normal tissues were collected from 80 patients with CCRCC. The mRNA and protein expression levels of CPEB4 were detected. The relationships between CPEB4 expression and clinicopathological characteristics as well as prognosis were analyzed.【Results】 The relative mRNA expression level of CPEB4 in tumor tissues(1.883 ± 0.053) was significantly higher than that in adjacent normal tissues(0.809 ± 0.032)(P<0.05). The positive rate of CPEB4 protein expression in tumor tissues was 63.8%(51/80), which was higher than that in normal tissues(31.3%, 25/80)(P<0.05). CPEB4 expression was associated with TNM stage, Fuhrman grade, and distant metastasis. Patients with negative CPEB4 expression had better survival than those with positive expression(P<0.05).【Conclusion】 CPEB4 is highly expressed in CCRCC tissues and is closely associated with clinicopathological features and prognosis.

Key words： Carcinoma, Renal Cell Immunohistochemistry

Received: 10 May 2025

PACS:

R737.11

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	Articles by authors
	LIU Zhengdao
	WANG Zhi
	XIE Liulei
	ZHANG Lei
	LI Xin
	WANG Hong

Cite this article:

LIU Zhengdao,WANG Zhi,XIE Liulei, et al. Expression Changes and Clinical Significance of CPEB4 in Clear Cell Renal Cell Carcinoma Tissues[J]. JOURNAL OF CLINICAL RESEARCH, 2026, 43(1): 63-65.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2026.01.017 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2026/V43/I1/63

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