膀胱癌患者血清CEA、CA19-9、β2-MG水平与预后的相关性分析

doi:10.3969/j.issn.1671-7171.2026.01.019

Abstract
Figure/Table
References (0)
Related Citation (15)

Download: PDF (1201 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】 To explore the correlation between prognosis and levels of serum carcinoembryonic antigen(CEA), carbohydrate antigen 19-9(CA19-9), and β2-microglobulin(β2-MG) in bladder cancer patients.【Methods】 The serum levels of CEA, CA19-9, and β2-MG were measured in 106 bladder cancer patients(the observation group) and 85 healthy individuals(the control group). The relationship between these markers and prognosis as well as the risk factors for death in bladder cancer patients were analyzed.【Results】 The levels of CEA, CA19-9, and β2-MG in the observation group were higher than those in the control group. Furthermore, the preoperative levels of these markers in the observation group were higher than their postoperative levels(all P<0.05). During a 36-month follow-up, 63 of the 106 bladder cancer patients survived(the survival group), while 43 died(the death group). The death group had a higher proportion of patients in TNM stages Ⅲ-Ⅳ and poorly differentiated tumors, as well as higher expression levels of CEA, CA19-9, and β2-MG compared to the survival group(P<0.05). Logistic multivariate regression analysis revealed that TNM stages Ⅲ-Ⅳ, poorly differentiated tumors, and high expression of CEA, CA19-9, and β2-MG were significant risk factors for death in bladder cancer patients(P<0.05). The 3-year survival rate in the high expression groups of CEA, CA19-9, and β2-MG was significantly lower than that in the low expression groups(P<0.05).【Conclusion】 Serum levels of CEA, CA19-9, and β2-MG are closely related to the prognosis of bladder cancer patients. These markers can serve as independent prognostic indicators for bladder cancer.

Key words： Urinary Bladder Neoplasms Carcinoembryonic Antigen CA19-9 Antigen Beta 2-Microglobulin Prognosis

Received: 19 March 2025

PACS:

R694

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	MENG Jiali
	LIN Hai
	MENG Wei

Cite this article:

MENG Jiali,LIN Hai,MENG Wei. Correlation Analysis of Serum CEA, CA19-9, and β2-MG Levels with Prognosis in Bladder Cancer Patients[J]. JOURNAL OF CLINICAL RESEARCH, 2026, 43(1): 69-72.

URL:

http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2026.01.019 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2026/V43/I1/69

[1] 张添辉,程亚宝,杜秀梅,等. 基于不同机器学习算法联合MRI影像组学构建膀胱癌肌层浸润预测模型的比较研究[J].实用放射学杂志,2024,40(6):940-943.
[2] 王浩宇,石文达,赵晓彬,等. 乳腺X线征象、ADC值联合血清CA125、CEA水平预测乳腺癌新辅助化疗后腋窝淋巴结病理状态的价值[J].放射学实践,2024,39(9):1178-1183.
[3] 胡菲,邹丹丹,韦丽光,等. DBT参数与CA19-9、ALP的相关性及对乳腺癌的诊断价值[J].中国实验诊断学,2024,28(7):795-798.
[4] 徐亚光,张静静,王天舒. 罗沙司他联合血液透析对尿毒症患者的疗效及对claudin-1、β2-MG水平的影响[J].国际泌尿系统杂志,2024,44(2):323-328.
[5] 路慧青,赵友为,刘巍. 膀胱癌病人血清miR-143-3p、ATG2B水平与临床病理及预后生存的关系[J].临床外科杂志,2024,32(7):757-761.
[6] 盛永亮,吕双武,张扬,等. 血清PON1联合AGR检测对膀胱癌根治术后尿道复发的预测价值[J].广东医学,2022,43(9):1150-1154.
[7] 王芳,齐亚鹏,刘学艳,等. 外周血NLR、CEA、D二聚体水平在胃癌根治术患者预后评估中的价值[J].实用癌症杂志,2023,38(5):734-736.
[8] 林承奎,朱成圣,王宇. CEA、CYFRA21-1联合影像学对肺癌患者预后判断的临床研究[J].中国临床药理学杂志,2024,40(10):1405-1408.
[9] 薛慧英,李鸿斌,赵少成. 术前血清sTim-3、HMGB1水平与肌层浸润性膀胱癌根治术后预后的关系[J].检验医学与临床,2024,21(16):2417-2421.
[10] 朱丽娜,魏翔宇,耿坚. 磁共振联合血清KMT2D检测在膀胱癌诊断中的临床意义[J].中国CT和MRI杂志,2024,22(1):114-116.
[11] 任文镇,王宏浩,向田,等. 术前外周血炎性参数与术后淋巴结比率在胃癌化疗患者预后中的作用[J].肿瘤防治研究,2023,50(5):490-497.
[12] 曾海荣,黄丹,张建军,等. 外周血CD4⁺CD25⁺、CD8⁺CD28⁺调节性T细胞水平对早期宫颈癌患者腹腔镜根治术后预后的预测价值[J].中国临床新医学,2024,17(7):800-805.
[13] 杨晶晶,殷丽霞,段婷,等. 胃癌组织中高表达ATP5A1与患者术后的不良预后和肿瘤细胞的糖代谢有关[J].南方医科大学学报,2024,44(5):974-980.
[14] 陈善勤,白傲祥,管佳佳,等. 降钙素受体表达与胃癌临床病理特征及预后的关系[J].中国综合临床,2024,40(5):369-374.

[1]	. [J]. JOURNAL OF CLINICAL RESEARCH, 2025, 42(9): 1645-1647.