复神灵窍汤治疗痰气郁结型精神分裂症的疗效

doi:10.3969/j.issn.1671-7171.2025.01.009

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (1178 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】To investigate the efficacy and clinical value of Fushen Lingqiao decoction in the treatment of Tanqi Yujie schizophrenia. 【Methods】A total of 80 patients with Tanqi Yujie schizophrenia who were admitted to our hospital from September 2022 to March 2023 were randomly divided into the control group (treated with conventional western medicine) and the observation group (treated with Fushen Lingqiao decoction on the top of the control group), with 40 cases in each group. The clinical efficacy, positive and negative symptom scale (PANSS) scores, Lowingston Occupational Therapy Cognitive Rating Scale (LOTCA) score, neurological function [brain-derived neurotrophic factor (BDNF), neuron-specific enolase (NSE), serotonin (5-HT)], endocrine function [melatonin (MT), thyroid-stimulating hormone (TSH), dopamine (DA)] and adverse reactions were compared between the two groups. 【Results】 The clinical effective rate of the observation group was higher than that of the control group, the difference was statistically significant (P<0.05). After treatment, the PANSS scores of the two groups were lower than those before treatment, their LOTCA scores were higher than those before treatment. The PANSS score of the observation group was lower than that of the control group, and the LOTCA score of the observation group was higher than that of the control group. The differences were statistically significant(P<0.05). After treatment, the serum levels of BDNF and 5-HT in the two groups were higher than those before treatment, and the NSE level was lower than before treatment. The levels of NSE in the observation group were higher than those in the control group, while the level of NSE in the observation group was lower than that in the control group. The differences were statistically significant (P<0.05). After treatment, the serum levels of MT, TSH and DA in the two groups were higher than those before treatment, and levels of MT, TSH and DA in the observation group was higher than those in the control group. The differences were statistically significant (P<0.05). The incidence of adverse reactions was 15.00% (6/40) in the observation group and 7.50% (3/40) in the control group, and the difference was not statistically significant (P>0.05). 【Conclusion】Fushen Lingqiao decoction combined with conventional western medicine has significant efficacy in the treatment of phlegm-qi schizophrenia, which can significantly improve clinical symptoms and cognitive function, regulate neurological function and endocrine function. It is safe treatment and is worthy of clinical promotion.

Key words： Schizophrenia Combined Application of Chinese Medicine and Western Medicine Treatment Outcome

Received: 10 July 2023

PACS:

R749.3

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	LIU Ting
	LI Qiong

Cite this article:

LIU Ting,LI Qiong. Observation of Therapeutic Effect of Fushen Lingjiao Decoction in the Treatment of Tanqi Yujie Schizophrenia[J]. JOURNAL OF CLINICAL RESEARCH, 2025, 42(1): 30-33.

URL:

http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2025.01.009 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2025/V42/I1/30

[1] DANIEL C J.Cognitive impairment associated with schizophrenia: from pathophysiology to treatment[J].Annu Rev Pharmacol Toxicol,2023,63(20):119-141.
[2] 程秀, 童亦滨, 李栋栋,等.贵州省某市社区精神分裂症患者免费发放药物管理效果研究[J].现代预防医学, 2019,46(2):265-269.
[3] JOSHUA T K, CHRISTOPH U C, RAKESH J,et al. New developments in the treatment of schizophrenia: an expert roundtable[J].Int J Neuropsychopharmacol,2023,26(5):322-330.
[4] 宁艳哲,朱虹,尹冬青,等.精神分裂症超高危人群研究现状及中医药干预思路探讨[J].中华中医药杂志, 2019,34(4):1334-1337.
[5] 徐义勇,艾志福,周步高,等.精神分裂症中医古籍文献考略[J].中华中医药杂志, 2019,34(9):4231-4233.
[6] 中华医学会精神病学分会.中国精神障碍分类与诊断标准第三版(精神障碍分类)[J].中华精神科杂志,2001,34(3):184-188.
[7] 国家中医药管理局.中医病证诊断疗效标准[M].南京:南京大学出版社,1994:67-69.
[8] 王长虹, 张伟平, 吕路线,等.河南省精神障碍流行病学调查精神分裂症流行情况分析[J].中华精神科杂志, 2020,53(1):23-28.
[9] 朱淼,尹岸民,张东良.奥氮平与利培酮对精神分裂症患者血清BDNF、NGF、IL-6水平的影响及临床应用效果比较[J].医学临床研究,2020,37(9):1340-1342.
[10] 林琴韵, 杨朝阳.中医药治疗精神分裂症研究进展[J].河南中医,2022,42(9):1429-1434.
[11] 张秀胜, 符为民, 王永生.符为民教授辨治精神分裂症思路及经验探讨[J].中国中西医结合杂志, 2019,39(7):881-883.
[12] JIE X S, CHENG F F, HUA L,et al. Traditional Chinese Medicine decoction combined with antipsychotic for chronic schizophrenia treatment: a systematic review and meta-analysis[J].Front Pharmacol,2020,20(11):616088.
[13] 潘琳琳, 王玉凤, 金坤,等.张志远治疗精神分裂症经验[J].中医杂志, 2019,60(1):14-16.
[14] 丁德正.试论“痰火扰心”[J].中华中医药杂志, 2022,37(2):809-812.
[15] 张毅杰, 李晶晶, 杭晓屹,等.近现代医家治疗癫狂的用药规律分析[J].世界中医药,2022,17(6):868-873.