The Clinical Efficacy of the Combination of Butylphthalide and Gangliosides in the Treatment of Acute Cerebral Infarction and its Impact on the Neurological Function of Patients
LU Hongli, ZHENG Haijing, MA Qi
The Seventh People's Hospital of Zhengzhou,Zhengzhou Henan 450000
Abstract 【Objective】To explore the clinical efficacy of the combination of butylphthalide and gangliosides in the treatment of acute cerebral infarction (ACI) and its impact on the neurological function of patients. 【Methods】A total of 98 ACI patients admitted to our hospital from March 2021 to December 2022 were selected and randomly divided into a control group and an observation group using a random number table method, with 49 cases in each group. The control group received treatment with gangliosides, while the observation group received treatment with a combination of butylphthalide and gangliosides. We compared two groups of clinical total effective rates, related scores [Barthel Index Rating Scale (BI), Stroke Specific Quality of Life Scale (SS-QOL), National Institutes of Health Stroke Scale (NIHSS)], neurological function indicators [Neuron Specific Enolase (NSE), Central Nervous System Specific Protein (S100β), Myelin Basic Protein (MBP)] levels, hemodynamic indicators(WBV, FIB) Blood cell hematocrit (HCT), coagulation factor (PV), and serum levels of vascular endothelial growth factor (VEGF), trimethylamine oxide (TMAO), thromboxane A2 (TXA2), and endothelin 1 (ET-1). 【Results】The total clinical effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). After treatment, the NIHSS score of the two groups of patients was lower than before treatment, while the BI score and SS-QOL score were higher than before treatment. The difference between the observation group and the control group was statistically significant (P<0.05); The levels of NSE, S100β, and MBP in both groups were lower than before treatment, while the observation group was lower than the control group, and the difference was statistically significant (P<0.05); The levels of HCT, WBV, FIB, and PV in the two groups of patients were lower than before treatment, and the observation group was lower than the control group, with statistical significance (P<0.05); The serum VEGF levels of the two groups were higher than before treatment, while the levels of ET-1, TMAO, and TXA2 were lower than before treatment. The difference between the observation group and the control group was statistically significant (P<0.05). 【Conclusion】The combination of butylphthalide and gangliosides has a good therapeutic effect on ACI, and improve the quality of life of patients.
LU Hongli,ZHENG Haijing,MA Qi. The Clinical Efficacy of the Combination of Butylphthalide and Gangliosides in the Treatment of Acute Cerebral Infarction and its Impact on the Neurological Function of Patients[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(2): 265-268.
2024, Vol. 41 
