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| Dynamic Changes in Hct, LP(a), MPV and their Correlation with Vascular Endothelial Function in Patients with Coronary Heart Disease after CABG Surgery |
| DENG Chuying, WANG Xiaohui, LI Chun |
| The Ninth People's Hospital of Zhengzhou,Zhengzhou Henan 450000 |
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Abstract 【Objective】To explore the dynamic changes in hematocrit (Hct), lipoprotein (a) [LP(a)], mean platelet volume (MPV), and their correlation with vascular endothelial function in patients with coronary heart disease after coronary artery bypass grafting (CABG). 【Methods】A total of 89 patients with coronary heart disease who underwent non extracorporeal circulation CABG surgery in our hospital from January 2020 to December 2022 were selected. They were divided into an angina group (n=30) and a non angina group (n=59) based on whether angina occurred 90 days after surgery. We compared the changes in Hct, LP(a), MPV levels, and vascular endothelial function indicators [endothelin-1 (ET-1), nitric oxide (NO)] between two groups of patients before surgery, 4 days after surgery, and 14 days after surgery. The correlation between Hct, LP(a), MPV levels and ET-1 and NO was analyzed at postoperative 4 days and 14 days, and the predictive value of Hct, LP(a), and MPV levels for recurrent angina after CABG was analyzed. 【Results】The Hct, LP(a), and MPV levels of the two groups of patients were lower than before surgery on the 4th and 14th postoperative days, and the non angina group was lower than the angina group, with statistical significance (P<0.05). At postoperative 4 days and 14 days, the levels of ET-1 in both groups were lower than before surgery, while the levels of NO were higher than before surgery, and the differences were statistically significant (P<0.05); The levels of ET-1 and NO in the non angina group were significantly different from those in the angina group (P<0.05). Pearson correlation analysis showed that Hct, LP(a), MPV were positively correlated with ET-1 (P<0.05) and negatively correlated with NO (P<0.05) at postoperative 4 days and 14 days. The analysis of the working characteristic curve of the subjects showed that the area under the curve of Hct, LP(a), and MPV combined prediction for postoperative angina pectoris in CABG was greater than that of single prediction (P<0.05). 【Conclusion】The dynamic changes of Hct, LP(a), and MPV in patients with coronary heart disease after CABG are related to vascular endothelial function. The combination of Hct, LP(a), and MPV has high clinical application value in predicting recurrent angina after CABG.
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Received: 07 April 2023
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2024, Vol. 41 
