Abstract 【Objective】To analyze the expression and value of miRNA-21 with related clinical indicators in lupus nephritis (LN) with renal failure. 【Methods】A total of of 85 patients with LN were selected in our hospital. Patients with renal failure were included in the observation group (n=19),the others were grouped as the control group (n=66). Levels of miRNA-21 and its related clinical indicators in serum were detected and compared between two groups,then receiver operating characteristic (ROC) curve analysis was used to evaluate the value of miRNA-21 in renal failure. Meanwhile,the influencing factors of renal failure were analyzed by using logistic regression analysis. 【Results】The estimate glomerular filtration rate (eGFR) and complement C3 levels in the observation group were lower than those in the control group,while the SLE disease activity index (SLEDAI)-2000 score,blood urea nitrogen (BUN),serum creatinine (Scr),erythrocyte sedimentation rate (ESR) and miRNA-21 in the observation group were significantly higher in the control group. The difference between the two groups was statistically significant (P<0.05).SLEDAI-2000 score,ESR and miRNA-21 were closely related to renal failure in LN,whose odds ratios (OR) (95%CI) were 3.137 (1.775-5.543),4.894 (2.472-9.687) and 1.227 (1.091-1.531),respectively.The area under the curve (AUC)(95%CI) of miRNA-21 in diagnosis of renal failure with LN was 0.78(0.65-0.91). 【Conclusion】The level of miRNA-21,SLEDAI-2000 score and ESR are higher in LN with renal failure,and miRNA-21 may be a useful indicator for diagnosing renal failure in LN.
SUN Ying,ZHUANG Li,SUN Li-ping, et al. Expression and Value of miRNA-21 and its Related Clinical Indicators in Lupus Nephritis with Renal Failure[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(5): 680-682.
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2023, Vol. 40 
