miRNA-21及相关临床指标在狼疮性肾炎肾衰竭患者中的表达及其意义

doi:10.3969/j.issn.1671-7171.2023.05.011

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Abstract 【Objective】To analyze the expression and value of miRNA-21 with related clinical indicators in lupus nephritis (LN) with renal failure. 【Methods】A total of of 85 patients with LN were selected in our hospital. Patients with renal failure were included in the observation group (n=19),the others were grouped as the control group (n=66). Levels of miRNA-21 and its related clinical indicators in serum were detected and compared between two groups,then receiver operating characteristic (ROC) curve analysis was used to evaluate the value of miRNA-21 in renal failure. Meanwhile,the influencing factors of renal failure were analyzed by using logistic regression analysis. 【Results】The estimate glomerular filtration rate (eGFR) and complement C3 levels in the observation group were lower than those in the control group,while the SLE disease activity index (SLEDAI)-2000 score,blood urea nitrogen (BUN),serum creatinine (Scr),erythrocyte sedimentation rate (ESR) and miRNA-21 in the observation group were significantly higher in the control group. The difference between the two groups was statistically significant (P<0.05).SLEDAI-2000 score,ESR and miRNA-21 were closely related to renal failure in LN,whose odds ratios (OR) (95%CI) were 3.137 (1.775-5.543),4.894 (2.472-9.687) and 1.227 (1.091-1.531),respectively.The area under the curve (AUC)(95%CI) of miRNA-21 in diagnosis of renal failure with LN was 0.78(0.65-0.91). 【Conclusion】The level of miRNA-21,SLEDAI-2000 score and ESR are higher in LN with renal failure,and miRNA-21 may be a useful indicator for diagnosing renal failure in LN.

Key words： Lupus Nephritis Renal Insufficiency MicroRNAs

Received: 09 May 2022

PACS:

R593.242

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	SUN Ying
	ZHUANG Li
	SUN Li-ping
	et al

Cite this article:

SUN Ying,ZHUANG Li,SUN Li-ping, et al. Expression and Value of miRNA-21 and its Related Clinical Indicators in Lupus Nephritis with Renal Failure[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(5): 680-682.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2023.05.011 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2023/V40/I5/680

[1] SOLÉ C,MOLINé T,VIDAL M,et al. An exosomal urinary mirna signature for early diagnosis of renal fibrosis in lupus nephritis[J].Cells,2019,8(8):773.
[2] 张彦平,贺军涛,殷鉴,等. 尿液免疫球蛋白轻链检测对系统性红斑狼疮肾脏损伤的诊断价值[J].陕西医学杂志,2020,49(9):1172-1174.
[3] PAN T Y,JIA P,CHEN N,et al. Delayed remote ischemic preconditioning confers renoprotection against septic acute kidney injury via exosomal miR-21[J].Theranostics,2019,9(2):405-423.
[4] ZHONG X,CHUNG A C,CHEN H Y,et al. miR-21 is a key therapeutic target for renal injury in a mouse model of type 2 diabetes [J].Diabetologia,2013,56(3):663-674.
[5] 中华医学会风湿病学分会. 系统性红斑狼疮诊断和治疗指南[J].中华风湿病学杂志,2010,14(5):342-346.
[6] 张明娇,吴勇. SLE及LN患者血清C1q的表达水平及意义[J].分子诊断与治疗杂志,2020,12(6):827-830.
[7] 龚妹羽,陈观生,刘伟敬,等. 狼疮性肾炎持续性蛋白尿影响因素研究进展[J].中国中西医结合肾病杂志,2017,18(8):744-746.
[8] GIADMAN D D,LBANEZ D,UROWITZ M B. Systemic lupus erythematosus disease activity index 2000 [J].J Rheumatol, 2002, 29(2):288-291.
[9] 鲁冰,任东升,王松. 三种微小RNA在糖尿病肾脏疾病肾纤维化患者中的水平变化及临床应用研究[J].中国糖尿病杂志,2019,27(3):189-193.
[10] 王雪艳,焦军东. MiR-21与肾脏疾病关系的研究进展[J].中国中西医结合肾病杂志,2017,18(3):259-261.
[11] 雷学智,徐小龙,胡建敏,等. MicroRNA-21在单侧输尿管梗阻大鼠间质纤维化肾脏组织中的表达及意义[J].重庆医学,2015,44(24):3319-3322.
[12] 袁芸,胡琼英. 糖尿病肾病中表达上调miRNA在肾脏内皮-间充质转化中的调控机制研究进展[J].山东医药,2020,60(32):85-89.
[13] LU X X.Ursolic acid attenuates diabetic mesangial cell injury through the up-regulation of autophagy via miRNA-21/PTEN/Ak/mTOR suppression[J].PLoS One,2015,10(2):e0117400.