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| Relationship of Serum PCT,CRP,SAA and IL-6 Levels with Respiratory Tract Infection in Patients with AECOPD |
| TAO Yun, WANG Xiao-xu |
| Department of Clinical Laboratory,Ankang People's Hospital,Ankang Shaanxi 725000 |
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Abstract 【Objective】 To explore the relationship of serum procalcitonin (PCT),C-reactive protein (CRP),serum amyloid A (SAA),and interleukin-6 (IL-6) levels with respiratory tract infection in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). 【Methods】 The clinical data of 85 patients with AECOPD admitted to our hospital from April 2019 to April 2022 were retrospectively analyzed. According to whether the patients were complicated with respiratory tract infection,they were divided into two groups,namely,the infected group (n=30) and the uninfected group (n=55). The general data and serum levels of PCT,CRP,SAA and IL-6 were compared between the two groups. The value of PCT,CRP,SAA and IL-6 in predicting respiratory tract infection in AECOPD patients was analyzed by ROC analysis. The risk factors of AECOPD patients complicated with respiratory tract infection were determined by multivariate logistic regression analysis. 【Results】 The proportion of patients with respiratory failure and AECOPD attacks ≥ 3 times within one year in the infected group was significantly higher than that in the uninfected group (P<0.05),and the levels of PCT,CRP,SAA and IL-6 in the infected group were significantly higher than those in the uninfected group (P<0.05). By ROC and logistic analysis,the areas under the curve of PCT,CRP,SAA and IL-6 predicting AECOPD patients with respiratory tract infection were 0.778,0.809,0.865 and 0.816,respectively (P<0.05). Respiratory failure,AECOPD attacks ≥ 3 times within 1 year,PCT≥4.795 μg/L,CRP≥5.730 mg/L,SAA≥25.310 mg/L and IL-6≥10.535 ng/L were the risk factors of respiratory tract infection in AECOPD patients (P<0.05). 【Conclusion】 The levels of serum PCT,CRP,SAA and IL-6 are closely related to AECOPD patients with respiratory tract infection,and can be used as serum indicators to assist in the diagnosis of AECOPD patients with respiratory tract infection.
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Received: 15 August 2022
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2023, Vol. 40 
