|
|
|
| Observation of Myocardial Injury Markers and T Lymphocyte Subsets in Children with Rotavirus Enteritis |
| ZHANG Xiaomei, ZHAO Yunai |
| Shenmu Hospital, Shenmu Shaanxi 719300 |
|
|
|
|
Abstract 【Objective】To explore the myocardial injury and changes in T lymphocytes in children with rotavirus enteritis and their correlation. 【Methods】 A retrospective analysis was conducted on 80 children with rotavirus enteritis admitted to our hospital from January 2019 to January 2022 (observation group). According to the severity of dehydration, the observation group was divided into non dehydration group (n=26), mild dehydration group (n=32), and moderate dehydration group (n=22). Another 80 children with enteritis who tested negative for rotavirus and were admitted to our hospital during the same period were selected as the control group. Myocardial injury biomarkers between two groups and cases with different degrees of dehydration [Creatine kinase (CK), creatine kinase isoenzyme (CK-MB), lactate dehydrogenase (LDH), α-hydroxybutyrate dehydrogenase (α-HBDH)] levels and T lymphocyte subpopulations (CD3+, CD4+, CD8+, and calculate the CD4+/CD8+ ratio) were compared.【Results】The levels of CK, CK-MB, LDH, and α-HBDH in the observation group were significantly higher than those in the control group, with statistical significance (P<0.05). The levels of CK, CK-MB, LDH, and α-HBDH in the mild and moderate groups of children were higher than those in the non dehydration group, while those in the moderate group were higher than those in the mild group, with statistical significance (P<0.05). The CD8+ in the observation group was higher than that in the control group, and the CD3+, CD4+, and CD4+/CD8+ values were lower than those in the control group, with statistical significance (P<0.05). The CD8+ levels in the mild and moderate groups were higher than those in the non dehydrated group, and the levels of CD3+, CD4+, and CD4+/CD8+ were lower than those in the non dehydrated group. Moreover, the above indicators in the mild group were significantly different from those in the moderate group (P<0.05). 【Conclusion】Myocardial injury markers and T lymphocyte subsets can accurately evaluate the dehydration status of children with early-stage viral enteritis, which is of great significance for guiding clinical treatment in the later stage.
|
|
Received: 06 October 2022
|
|
|
|
|
|
[1] WANG X Y, YANG Q, ZHOU X F, et al. Shenling Baizhu powder inhibits RV-SA11-Induced inflammation and rotavirus enteritis via TLR4/MyD88/NF-κB signaling pathway[J].Front Pharmacol,2021,12(9):642685.
[2] 孙蓓蓓,封东进,王光猛,等. 葡萄糖酸锌颗粒联合消旋卡多曲颗粒对轮状病毒肠炎患儿血浆炎性因子、心肌酶指标及免疫功能的影响[J].现代生物医学进展,2020,20(23):4543-4546.
[3] 张向荣,汪宏斌,李红. 轮状病毒肠炎患儿并发心肌损伤的危险因素分析[J].中西医结合心脑血管病杂志,2021,19(8):1361-1363.
[4] 中华医学会儿科学分会消化学组,中华医学会儿科学分会感染学组,《中华儿科杂志》编辑委员会. 儿童腹泻病诊断治疗原则的专家共识[J].中华儿科杂志,2009,47(8):634-636.
[5] KIM J H, KIM K, KIM W. Genipin inhibits rotavirus-induced diarrhea by suppressing viral replication and regulating inflammatory responses[J].Sci Rep,2020,10(1):15836.
[6] 李燕,邵利红. 双歧三联活菌联合重组人干扰素α1b对轮状病毒肠炎患儿肠道菌群和心肌损伤标志物的影响[J].中国妇幼保健,2021,36(8):1793-1796.
[7] ARAKAKI L, TOLLEFSON D, KHARONO B,et al. Prevalence of rotavirus among older children and adults with diarrhea: A systematic review and meta-analysis[J].Vaccine,2021,39(33):4577-4590.
[8] 尚小玉,聂楠. CRP、心肌损伤标志物、肝功能检测在小儿轮状病毒感染性腹泻诊治中的应用价值[J].贵州医药,2021,45(3):454-455.
[9] 王淑珍. 轮状病毒感染腹泻并心肌损伤患儿心肌酶学指标变化及其危险因素[J].临床与病理杂志,2021,41(6):1294-1299.
[10] 王正华,丁培,许乔雯,等. 五加减正气散治疗寒湿型小儿轮状病毒肠炎的效果及对血清心肌损伤标志物、炎症因子的影响[J].中国医药导报,2021,18(33):107-110.
[11] 孟祥会,陈营,董旭. NF-κB、25-(OH)D3、CK-MB在儿童病毒性腹泻中的表达及临床意义[J].中国实验诊断学,2022,26(2):225-228.
[12] LIU P, ZOU R, ZHAO J, et al. Changes in humoral immunity, myocardial damage, trace elements, and inflammatory factor levels in children with rotavirus enteritis[J].Am J Transl Res,2022,14(1):452-459.
[13] 王艳妮,钟文,丁琳,等. 轮状病毒感染患儿Treg/Th17平衡与NK细胞及白细胞介素-37的表达及意义[J].中华医院感染学杂志,2020,30(3):433-437.
[14] 杨雨婷,张冉,汪雅,等.Treg/Th17失衡及体液免疫功能紊乱与轮状病毒肠炎伴心肌损害患儿发病风险的关系[J].中国病原生物学杂志,2022,17(6):689-692. |
|
|
|
2023, Vol. 40 
