Abstract 【Objective】To investigate the effects of different doses of atropine on short-term prognosis of patients with acute organophosphorus pesticide poisoning (AOPP). 【Methods】A total of 120 patients with AOPP were randomly divided into high-dose group and low-dose group, with 60 patients in each group. The high-dose group received an initial dose of atropine of 5-10 mg, and intravenous injection of 2-5 mg every 10-30 min according to the patient's response, until the patient was atropinized. The low-dose group received an initial dose of atropine of 2-5 mg, and intravenous injection of 1-2 mg every 10-30 min according to the patient's response, until the patient was atropinized. The clinical efficacy, changes in blood cell parameters [white blood cell count (WBC), neutrophil count (NC), lymphocyte count (LC), and neutrophil/lymphocyte ratio (NLR)], changes in C-reactive protein (CRP), eosinophils (EOS), acetylcholinesterase (AchE), superoxide dismutase (SOD), malondialdehyde (MDA) levels, and drug safety were compared between the two groups.【Results】The cure rate in the high-dose group was 85.00% (51/60), which was significantly better than 68.33% (41/60) in the low-dose group (P<0.05). The amount of atropine used in the high-dose group was significantly higher than that in the low-dose group (P<0.05), but there was no significant difference in mechanical ventilation, ICU stay, and hospital stay between the two groups (P>0.05). After treatment, WBC, NC, and NLR in both groups were lower than before treatment, while LC was higher than before treatment (P<0.05); CRP and EOS were lower than before treatment (P<0.05); AchE and SOD were higher than before treatment, while MDA was lower than before treatment (P<0.05); and the above indexes in the high-dose group were better than those in the low-dose group (P<0.05). The incidence of adverse events in the high-dose group was slightly higher than that in the low-dose group, but there was no significant difference between the two groups (P>0.05). 【Conclusion】 High-dose atropine treatment for AOPP is significantly better than low-dose treatment, which can significantly improve blood cell parameters, regulate inflammatory factors and oxidative stress levels, and has good drug safety.
YAN Wanshu,CHANG Yuxin,YAO Weiwei, et al. Effects of Different Doses of Atropine on Short-term Prognosis of Patients with Acute Organophosphorus Pesticide Poisoning[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(10): 1496-1499.