Abstract 【Objective】To investigate the expression levels of TP53INP1 and RAI2 in triple-negative breast cancer (TNBC) tissues and their relationships with the clinical and pathological characteristics and prognosis of patients. 【Methods】The protein expression levels of TP53INP1 and RAI2 in 168 TNBC patients were detected and analyzed in relation to the patients' clinical and pathological characteristics and prognosis. 【Results】The positive rates of TP53INP1 and RAI2 in TNBC cancer tissues were 23.21% (39/168) and 32.74% (55/168) respectively, significantly lower than the 53.57% (90/168) and 58.93% (99/168) in adjacent non-tumor tissues (P<0.05). The expression level of TP53INP1 was correlated with lymph node metastasis, histological grade, and TNM staging (P<0.05), while the expression level of RAI2 was correlated with lymph node metastasis and histological grade (P<0.05). Univariate analysis showed that lymphatic metastasis, TNM stage, TP53INP1 expression, and RAI2 expression were risk factors affecting overall survival and disease-free survival rates. The 5-year disease-free survival rate and overall survival rate of groups without lymph node metastasis, TNM stages Ⅰ-Ⅱ,high TP53INP1 expression, and high RAI2 expression were significantly higher than their corresponding groups, with statistically significant differences (P<0.05). Cox hazard regression model analysis showed that the expressions of TP53INP1, RAI2, and lymph node metastasis were independent prognostic factors affecting disease-free survival. 【Conclusion】The expression levels of TP53INP1 and RAI2 are closely related to the occurrence, progression, and poor prognosis of TNBC. High expression of TP53INP1 and RAI2 may indicate a good prognosis.
PANG Zongxin,SUN Xuan,LIANG Qingna, et al. Expression of TP53INP1 and RAI2 in Triple-Negative Breast Cancer and their Relationship with Patient Prognosis[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(10): 1500-1503.
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2023, Vol. 40 
