颈动脉狭窄与糖尿病和肥胖相关基因的相关性分析

doi:10.3969/j.issn.1671-7171.2022.06.011

Abstract
Figure/Table
References (0)
Related Citation (15)

Download: PDF (1149 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】 To investigate the relationship between 14 gene loci related to risk factors such as diabetes and obesity and carotid artery stenosis. 【Methods】A total of 196 patients with carotid artery stenosis (observation group) admitted to the neurosurgery department of our hospital were selected. The carotid artery stenosis was diagnosed by CTA or DSA. A total of 360 volunteers (control group) who underwent physical examination in our hospital during the same period were selected. 14 loci of 12 genes,including CAMTA1,SLC30A8,CDKN2A/B,TCF7L2,SLC2A9,IGF1,PDGFB,FTO,KCNJ15,ESR1,were genotyped. The differences in SNP locus gene frequencies between the two groups were compared by Pearson χ². 【Results】 The analysis of 14 candidate SNP loci showed that the frequency of ESR1 rs722208 allele G in the observation group was higher than that in the control group (P=0.019),and the frequency of KCNJ15 rs3746876 allele T was higher than that in the control group (P=0.034). In this study,115 patients with unilateral carotid artery stenosis and 81 patients with bilateral carotid artery stenosis were observed in the observation group. Further analysis was made on the association between the genotype of ESR1 rs722208 and KCNJ15 rs3746876 and the number of carotid artery lesions. There was significant difference between patients with bilateral carotid artery stenosis and the control group ESR1 rs722208 (P=0.007,OR=1.628,95%CI:1.139~2.326) and KCNJ15 rs3746876 (P=0.026,OR=1.809,95%CI:1.066~3.073) (P<0.05). 【Conclusion】ESR1 rs722208 and KCNJ15 rs3746876 mutations may be related to the occurrence and development of carotid artery stenosis.

Key words： Carotid Stenosis Diabetes Mellitus Obesity Genes

Received: 06 May 2021

PACS:

R654.3

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHANG Li-tong
	LI Ran
	LIANG Hong-lei
	et al

Cite this article:

ZHANG Li-tong,LI Ran,LIANG Hong-lei, et al. Correlation Analysis of Carotid Artery Stenosis with Diabetes and Obesity Related Genes[J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(6): 838-842.

URL:

http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2022.06.011 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2022/V39/I6/838

[1] NING G,BLOOMGARDEN Z. Diabetes in China:prevalence,diagnosis,and control[J].J Diabetes,2013,5(4):372.
[2] TRAYLOR M,FARRALL M,HOLLIDAY E G,et al. Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration):a meta-analysis of genome-wide association studies[J].Lancet Neurol,2012,11(11):951-962.
[3] ZHANG X,MU Y,YAN W,et al. Prevalence of stroke and metabolic disorders in the middle-aged and elderly Chinese with type 2 diabetes[J].Chin Med J (Engl),2014,127(20):3537-3542.
[4] TUTTOLOMONDO A,PINTO A,DI R D,et al. Prospective study of type 1 and type 2 diabetes and risk of stroke subtypes:the Nurses' Health Study:response to Janghorbani et al[J].Diabetes Care,2007,30(11):e114.
[5] ISO H,IMANO H,KITAMURA A,et al. Type 2 diabetes and risk of non-embolic ischaemic stroke in Japanese men and women[J].Diabetologia,2004,47(12):2137-2144.
[6] BEVAN S,TRAYLOR M,ADIB-SAMII P,et al. Genetic heritability of ischemic stroke and the contribution of previously reported candidate gene and genomewide associations[J].Stroke,2012,43(12):3161-3167.
[7] LAZAROS L,MARKOULA S,XITA N,et al. Association of estrogen receptor-alpha gene polymorphisms with stroke risk in patients with metabolic syndrome[J].Acta Neurol Scand,2008,117(3):186-190.
[8] STRAND M,SODERSTROM I,WIKLUND P G,et al. Estrogen receptor alpha gene polymorphisms and first-ever intracerebral hemorrhage[J].Cerebrovasc Dis,2007,24(6):500-508.
[9] OKAMOTO K,IWASAKI N,DOI K,et al. Inhibition of glucose-stimulated insulin secretion by KCNJ15,a newly identified susceptibility gene for type 2 diabetes[J].Diabetes,2012,61(7):1734-1741.
[10] SOUSA A G,MARQUEZINE G F,LEMOS P A,et al. TCF7L2 polymorphism rs7903146 is associated with coronary artery disease severity and mortality[J].PLoS One,2009,4(11):e7697.
[11] LUSCHER T F,CREAGER M A,BECKMAN J A,et al. Diabetes and vascular disease:pathophysiology,clinical consequences,and medical therapy:Part Ⅱ[J].Circulation,2003,108(3):1655-1661.
[12] CAUCHI S,PROENCA C,CHOQUET H,et al. Analysis of novel risk loci for type 2 diabetes in a general French population:the D.E.S.I.R. study[J].J Mol Med (Berl),2008,86(3):341-348.
[13] BOCHENEK G,HASLER R,EL MOKHTARI N E,et al. The large non-coding RNA ANRIL,which is associated with atherosclerosis,periodontitis and several forms of cancer,regulates ADIPOR1,VAMP3 and C11ORF10[J].Hum Mol Genet,2013,22(22):4516-4527.
[14] MOTTERLE A,PU X,WOOD H,et al. Functional analyses of coronary artery disease associated variation on chromosome 9p21 in vascular smooth muscle cells[J].Hum Mol Genet,2012,21(18):4021-4029.
[15] LYSSENKO V,LUPI R,MARCHETTI P,et al. Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes[J].J Clin Invest,2007,117(8):2155-2163.
[16] BURACZYNSKA M,SWATOWSKI A,MARKOWSKA-GOSIK D,et al. Transcription factor 7-like 2 (TCF7L2) gene polymorphism and complication/comorbidity profile in type 2 diabetes patients[J].Diabetes Res Clin Pract,2011,93(3):390-395.
[17] OWENS G K,KUMAR M S,WAMHOFF B R. Molecular regulation of vascular smooth muscle cell differentiation in development and disease[J].Physiol Rev,2004,84(3):767-801.
[18] IMAI Y,CLEMMONS D R. Roles of phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways in stimulation of vascular smooth muscle cell migration and deoxyriboncleic acid synthesis by insulin-like growth factor-I[J].Endocrinology,1999,140(9):4228-4235.
[19] WINTER Y,SANKOWSKI R,BACK T. Genetic determinants of obesity and related vascular diseases[J].Vitam Horm,2013,91:29-48.
[20] AL-ATTAR S A,POLLEX R L,BAN M R,et al. Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample[J].Cardiovasc Diabetol,2008,7:5.
[21] HELLSTROM M,KALEN M,LINDAHL P,et al. Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse[J].Development,1999,126(14):3047-3055.
[22] MCDONOUGH C W,PALMER N D,HICKS P J,et al. A genome-wide association study for diabetic nephropathy genes in African Americans[J].Kidney Int,2011,79(5):563-572.
[23] O'DONNELL C J,CUPPLES L A,D'AGOSTINO R B,et al. Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study[J].BMC Med Genet,2007,8(Suppl 1):S4.