血清MMP-9、β-hCG联合检测对胎膜早破合并宫内支原体感染的预测价值

doi:10.3969/j.issn.1671-7171.2022.06.012

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Abstract 【Objective】To investigate the predictive value of serum matrix metalloproteinase-9 (MMP-9) and β-human chorionic gonadotropin (β-hCG) in predicting premature rupture of membranes (PROM) complicated with intrauterine mycoplasma infection. 【Methods】A total of 199 cases of PROM pregnant women in AVIC Xi'an Hospital from March 2018 to May 2020 were selected. They were divided into non infection group (126 cases) and mycoplasma infection group (73 cases) according to the pathological examination of postpartum fetal membrane. Another 100 cases of normal pregnant women in our hospital during the same period were selected as the control group. The expression levels of MMP-9 and β-hCG in serum were detected by enzyme-linked immunosorbent assay (ELISA),body mass index (BMI),birth history,abortion/induced labor history,gestational diabetes mellitus and pregnancy induced hypertension were collected and compared among the three groups; the receiver operating characteristic (ROC) curve was drawn to evaluate the predictive value of serum MMP-9 and β-hCG in pregnant women with PROM complicated with intrauterine mycoplasma infection; and multivariate Logistic regression model was used to analyze the influencing factors of PROM complicated with intrauterine mycoplasma infection. 【Results】There were no significant differences in age,BMI,gestational weeks,the proportion of primipara and the proportion of gestational diabetes mellitus between the control group,the non infection group and the mycoplasma infection group (P>0.05),while the differences in the proportion of abortion/induced labor history and the proportion of pregnancy induced hypertension were statistically significant (P<0.05); compared with those in the control group,the levels of serum MMP-9 and β-hCG in the non infection group and the mycoplasma infection group were higher (P<0.05); compared with those in the non infection group,the levels of serum MMP-9 and β-hCG in the mycoplasma infection group were higher (P<0.05); the area under the curve (AUC) of serum MMP-9 and β-hCG in predicting PROM complicated with intrauterine mycoplasma infection in pregnant women was 0.814,0.834,respectively,the cut-off value was 370.72 ng/L and 16.46 mol/ml,respectively,the sensitivity was 74.00% and 83.60% respectively,the specificity was 77.00% and 71.00%,respectively. The AUC of combined prediction was 0.907,the sensitivity was 79.50%,and the specificity was 88.50%; the high expression of MMP-9 and the high expression of β-hCG were independent risk factors of PROM complicated with intrauterine mycoplasma infection (P<0.05). 【Conclusion】The levels of serum MMP-9 and β-hCG are closely related to the occurrence of PROM complicated with intrauterine mycoplasma infection in pregnant women. The combined diagnosis efficiency of the two methods is high,which may be the auxiliary biological indicators for the early diagnosis of PROM complicated with intrauterine mycoplasma infection.

Key words： Fetal Membranes, Premature Rupture/CO Mycoplasma Infections Metalloproteases/BL Chorionic Gonadotropin, beta Subunit, Human/BL

Received: 06 December 2021

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R681.2

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	LI Hong-ni
	GUO Liang
	XI Cui-ping

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LI Hong-ni,GUO Liang,XI Cui-ping. Predictive Value of Serum MMP-9 and β-hCG for Premature Rupture of Membranes Complicated with Intrauterine Mycoplasma Infection[J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(6): 843-846.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2022.06.012 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2022/V39/I6/843

[1] 宋春红,马倩,甄娟,等. NOD2、TNF-α、MMP-9及Caspase-3在胎膜早破发病中的作用及意义[J].天津医药,2019,47(4):417-420.
[2] BROWN R G,MARCHESI J R,LEE Y S,et al. Vaginal dysbiosis increases risk of preterm fetal membrane rupture,neonatal sepsis and is exacerbated by erythromycin[J].BMC Med,2018,16(1):9-23.
[3] 程荣琴,余蓓萌,赵萍萍,等. 产妇宫内感染对早产儿免疫功能及细胞因子水平的影响[J].中华医院感染学杂志,2018,28(3):448-451.
[4] 应海琼,徐道芬,单晓雪,等. 晚期妊娠宫内感染对母婴的影响[J].中华医院感染学杂志,2019,29(4):614-616.
[5] ZHANG S M,TIAN F J,ZENG W H,et al. XCL1-XCR1 pathway promotes trophoblast invasion at maternal-fetal interface by inducing MMP-2/MMP-9 activity[J].Am J Reprod Immunol,2018,80(3):1-11.
[6] 张岩,杨飚,范娟,等. 血清β-人绒毛膜促性腺激素与C-反应蛋白对胎膜早破妊娠患者宫内感染的预测效果[J].中华医院感染学杂志,2018,28(6):911-914.
[7] 中华医学会妇产科学分会产科学组. 胎膜早破的诊断与处理指南(2015)[J].中华围产医学杂志,2015,18(3):161-167.
[8] 朱薏,路妍妍,田耕. 未足月胎膜早破产妇及新生儿结局的影响因素分析[J].实用医学杂志,2018,34(12):2046-2048.
[9] 宋宇博. 早产胎膜早破产妇残余羊水指数与母儿结局的关系[J].医学临床研究,2019,36(5):954-956.
[10] 李燕,张金玲,安文茜,等. 宫内感染产妇血清及羊水MMP-2、MMP-9含量与新生儿脑损伤的相关性分析[J].中国医师杂志,2020,22(4):574-576.
[11] 王倩,鲍雪,卢丹. MST4、TRAF6及NF-κB在胎膜早破合并宫内感染患者中的表达及临床意义[J].中国医师杂志,2020,22(5):704-708.
[12] 邓睿,刘杰,林佳,等. 胎膜早破孕妇胎膜组织中HLA-G、MMP-9的表达及意义[J].中国妇幼保健,2018,33(20):4575-4578.
[13] ZIOLKOWSKA K,DYDOWICZ P,SOBKOWSKI M,et al. The clinical usefulness of biochemical (free β-hCg,PaPP-a) and ultrasound (nuchal translucency) parameters in prenatal screening of trisomy 21 in the first trimester of pregnancy[J].Ginekol Pol,2019,90(3):161-166.