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| Value of Combined Detection of Tissue MicroRNA in Predicting 1-year Survival Rate of Cervical Cancer |
| WANG Qiao-ge, TIAN Lu |
| Department of Pathology, Northwest Women's and Children's Hospital, Xi'an Shaanxi 710061 |
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Abstract 【Objective】To explore the value of combined detection of MicroRNA in cervical cancer tissues in predicting the 1-year survival rate of cervical cancer. 【Methods】A total of 70 patients with cervical cancer admitted to Northwest Women's and Children's hospital from April 2017 to April 2019 were selected for the study. All selected patients were followed up for one year. The 1-year survival rate of the patients was counted and divided into the death group (n=12) and the survival group (n=58). The age, FIGO stage, pathological grade, lymph node metastasis and tumor size of the two groups were compared. MicroRNA-21 (miR-21), microRNA-143 (miR-143) and microrna-373 (miR-373) were measured immediately after admission. Multivariate Logistic regression analysis was used to investigate the risk factors of cervical cancer death in 1-year survival. 【Results】The proportion of age>50 years old, FIGO Ⅲ and Ⅳ stage, moderately differentiated and poorly differentiated in pathological grade, lymph node metastasis and tumor size larger than 4 cm in the death group was significantly higher than that in survival group. The difference was statistically significant(P<0.05).The Ct value of miR-21 in the dead group was significantly lower than that in the survival group. The difference was statistically significant (P<0.05).The Ct values of miR-143 and miR-373 in the death group were significantly higher than those in the surviving group, and the difference were statistically significant (P<0.05).Age > 50 years, FIGO stage Ⅲ/Ⅳ, low differentiation, lymph node metastasis, tumor size >4 cm, miR-21＜20.10,miR-143＞26.23 and miR-373＞34.55 were risk factors for 1-year death in cervical cancer patients (P<0.05). 【Conclusion】MicroRNA is associated with the prognosis of cervical cancer, which can provide valuable reference,if combined with other clinical information of patients, for the evaluation of 1-year survival rate of cervical cancer.
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Received: 03 December 2021
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2022, Vol. 39 
