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| Effects of Mifepristone Combined with Guizhi Fuling Capsule on Serum Estrogen, Progesterone and Oxidative Stress Factors in Patients with Uterine Fibroids |
| ZHENG Yu, DAI Qiu-xiang, LIANG Ju, et al |
| Department of Pharmacy, Hainan Modern Women and Children's Hospital, Hainan Haikou 571100 |
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Abstract 【Objective】 To investigate the effect of mifepristone combined with Guizhi Fuling Capsule on serum estrogen, progesterone and oxidative stress factors in patients with uterine fibroids.【Methods】 A total of 66 patients with uterine fibroids in our hospital from January 2017 to February 2018 were selected and divided into observation group and control group according to different treatment methods. The control group was treated with mifepristone, and the observation group was treated with Guizhi Fuling Capsule on the basis of the control group. The clinical efficacy, serum levels of estradiol (E2), progesterone (P), matrix metalloproteinase-2 (MMP-2), MMP-9, malondialdehyde (MDA), superoxide dismutase (SOD), human epididymal protein 4 (HE4) and hemorheological indexes were observed before and after treatment. The recurrence rate of uterine fibroids was observed after 1 year follow-up.【Results】 Before treatment, there was no significant difference in uterine fibroid volume, MMP-2, MMP-9, P, E2, HE4, MDA, SOD levels between the two groups before treatment (P>0.05); after treatment, the uterine fibroid volume of the observation group was smaller than that of the control group, the levels of MMP-2, MMP-9, P, E2, HE4 and MDA in the observation group were significantly lower than those in the control group, and the SOD level was significantly higher than that in the control group (P<0.05); there was no difference in the hemorheological indexes between the two groups before treatment. After treatment, the whole blood high shear viscosity, low shear viscosity and plasma viscosity of the observation group were significantly lower than those of the control group (P<0.05). There was no significant difference in adverse reactions and recurrence rate after 3 months between the two groups (P>0.05). 【Conclusion】 Mifepristone combined with Guizhi Fuling Capsule in the treatment of uterine leiomyoma can reduce the volume of leiomyoma, reduce the expression levels of estrogen, progesterone and HE4, improve hemorheological indexes, reduce oxidative stress injury, and has high safety, which is worthy of clinical application.
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Received: 05 June 2019
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2020, Vol. 37 
