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| Correlation Analysis of Anticardiolipin Antibodies with Severity of Hypertensive Disorder Complicating Pregnancy and Outcomes of Maternal and Infant |
| LI Jun, XU Ying, HU Zheng |
| Department of Obstetrics and Gynecology, Minhang District Central Hospital, Shanghai 201199 |
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Abstract 【Objective】 To investigate the effects of anticardiolipin antibodies (ACA) on the severity of hypertensive disorder complicating pregnancy (HDCP) and outcomes in maternal and fetal. 【Methods】 A total of 133 pregnant women with gestational hypertension who received childbirth in our hospital from January to February 2018 were selected as the observation group. According to the severity of the disease, the patients were divided into the hypertension group (n=56) and the preeclampsia group (n=77). During the same period, 50 normal pregnant women who gave birth in our hospital were enrolled in the control group. The levels of anticardiolipin antibodies (ACA), blood pressure, urine protein, maternal and infant outcomes premature delivery, fetal growth restriction, placental abruption, perinatal death were compared among groups. The relationship of anticardiolipin antibody levels (ACA-IgG, ACA-IgM and ACA-IgA) with blood pressure, urine protein, and maternal and fetal outcomes was analyzed. 【Results】 The ACA-IgG, ACA-IgM, diastolic blood pressure, systolic blood pressure and urine protein levels in the preeclampsia group and hypertension group were higher than those in the control group (P<0.05). The ACA-IgG, ACA-IgM, diastolic blood pressure, systolic blood pressure and urine protein levels in the preeclampsia group were higher than those in the hypertension group (P<0.05). There was no significant difference in ACA-IgA between the three groups (P>0.05). The incidence of premature delivery, fetal growth restriction, placental abruption, and perinatal death in the preeclampsia group was significantly higher than that in the hypertension group (P<0.05). The incidence of premature delivery, fetal growth restriction, placental abruption, and perinatal death in the hypertension group was significantly higher than that in the control group (P<0.05). ACA-IgG was positively correlated with systolic blood pressure, diastolic blood pressure and premature birth (r=0.317, 0.453, 0.521, P<0.05). ACA-IgM was positively correlated with premature delivery and placental abruption (r=0.650, 0.524, P<0.05). 【Conclusion】 The serum ACA level of pregnant women with hypertensive disorder complicating pregnancy is closely related to the severity of the disease and outcomes of maternal and infant. The detection of serum ACA level has certain reference value for predicting the outcome of poor maternal and child.
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Received: 15 July 2019
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2020, Vol. 37 
