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| Correlation between Prognosis and Depth of Invasion and Postoperative Chemotherapy in Primary Bladder Adenocarcinoma |
| ZHANG Lu, DUAN Wei, SUN Xiao-dong, et al |
| Department of Oncology, Yan'an University Affiliated Hospital, Yan'an, Shaanxi 716000 |
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Abstract 【Objective】To investigate the effect of tumor invasion depth and postoperative adjuvant chemotherapy on the prognosis of patients with primary bladder adenocarcinoma. 【Methods】 A total of 78 patients with primary bladder adenocarcinoma treated in our hospital were divided into survival group (49 cases) and death group (29 cases) according to the 3-year follow-up results. The age, gender, operation mode, pathological stage, pathological differentiation degree, tumor number, maximum diameter of lesion, depth of invasion, lymph node metastasis and postoperative adjuvant chemotherapy were compared between the two groups. Cox proportional hazard regression model was used to analyze the related factors affecting the prognosis of patients. 【Results】There was no significant difference in age, gender, operation mode, tumor number and maximum diameter between the two groups (P>0.05); there were significant differences in pathological stage, tumor differentiation degree, depth of invasion, postoperative adjuvant chemotherapy between survival group and death group (P<0.05); Cox proportional hazard model analysis showed that: the increased pathological stage of primary bladder adenocarcinoma, the decreased tumor differentiation and myometrial invasion were independent risk factors for poor prognosis (P<0.05). Postoperative adjuvant chemotherapy had no significant effect on the prognosis of patients (P>0.05). 【Conclusion】There are many factors that affect the prognosis of patients with primary bladder adenocarcinoma. Myometrial invasion is one of the independent risk factors. However, the effect of postoperative adjuvant chemotherapy on prognosis is not significant, which may need to be further extended for further study.
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Received: 08 May 2020
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2020, Vol. 37 
