Expression and Significance of Serum Silent Information Regulatory Factor-2-related Enzyme-1 (SIRT1) with Cardiac Function NYHA Classification in Patients with Chronic Heart Failure
YU Yan-yan, WU Cong
Shandong Provincial Third Hospital, Jinan Shandong, 250031, China
Abstract【Objective】To investigate the relationship between serum silent information regulator 2-related enzyme 1 (SIRT1) level and cardiac function NYHA classification in patients with chronic heart failure (CHF). 【Methods】A total of 103 patients with CHF in our hospital from January 2017 to June 2018 were selected as the observation group, and 51 healthy volunteers in the same period were selected as the control group. Serum SIRT1 levels were detected. Serum SIRT1 levels of patients with different NYHA grades in the two groups were compared. The correlation between serum SIRT1 levels and NYHA grading was analyzed. The serum SIRT1 levels of patients with different prognosis were compared after 2 years of follow-up. 【Results】The serum SIRT1 level in the observation group was lower than that in the control group and the difference was statistically significant (P<0.05). With increase of NYHA grade, the serum SIRT1 level decreased and the difference was statistically significant (P<0.05). The Pearson correlation coefficient model analysis showed that the serum SIRT1 level was negatively correlated with NYHA grade (P<0.05) The 2-year mortality rate was 23.47% (23/98) and serum SIRT1 level of the patients who died was lower than that of the patients who survived (P<0.05). 【Conclusion】Serum SIRT1 level in CHF patients is significantly decreased and the degree of reduction is closely related to cardiac function and prognosis, which can provide reference for clinical evaluation of cardiac function and prognosis and guide the improvement of treatment plan.
YU Yan-yan,WU Cong. Expression and Significance of Serum Silent Information Regulatory Factor-2-related Enzyme-1 (SIRT1) with Cardiac Function NYHA Classification in Patients with Chronic Heart Failure[J]. JOURNAL OF CLINICAL RESEARCH, 2020, 37(12): 1847-1849.
2020, Vol. 37 
