血清沉默信息调节因子2相关酶1水平变化与慢性心力衰竭患者NYHA分级及临床意义

doi:10.3969/j.issn.1671-7171.2020.12.026

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (0 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】To investigate the relationship between serum silent information regulator 2-related enzyme 1 (SIRT1) level and cardiac function NYHA classification in patients with chronic heart failure (CHF). 【Methods】A total of 103 patients with CHF in our hospital from January 2017 to June 2018 were selected as the observation group, and 51 healthy volunteers in the same period were selected as the control group. Serum SIRT1 levels were detected. Serum SIRT1 levels of patients with different NYHA grades in the two groups were compared. The correlation between serum SIRT1 levels and NYHA grading was analyzed. The serum SIRT1 levels of patients with different prognosis were compared after 2 years of follow-up. 【Results】The serum SIRT1 level in the observation group was lower than that in the control group and the difference was statistically significant (P<0.05). With increase of NYHA grade, the serum SIRT1 level decreased and the difference was statistically significant (P<0.05). The Pearson correlation coefficient model analysis showed that the serum SIRT1 level was negatively correlated with NYHA grade (P<0.05) The 2-year mortality rate was 23.47% (23/98) and serum SIRT1 level of the patients who died was lower than that of the patients who survived (P<0.05). 【Conclusion】Serum SIRT1 level in CHF patients is significantly decreased and the degree of reduction is closely related to cardiac function and prognosis, which can provide reference for clinical evaluation of cardiac function and prognosis and guide the improvement of treatment plan.

Key words： Heart Failure Chronic Disease Silent Information Regulator Proteins/BL

Received: 14 September 2020

PACS:

R541.6

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	YU Yan-yan
	WU Cong

Cite this article:

YU Yan-yan,WU Cong. Expression and Significance of Serum Silent Information Regulatory Factor-2-related Enzyme-1 (SIRT1) with Cardiac Function NYHA Classification in Patients with Chronic Heart Failure[J]. JOURNAL OF CLINICAL RESEARCH, 2020, 37(12): 1847-1849.

URL:

http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2020.12.026 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2020/V37/I12/1847

[1] 黄洁,杨海英,王德伟,等.循环组织型金属蛋白酶抑制剂4与可溶性E选择素联合检测对慢性心力衰竭病情及预后的评估价值[J].中国心血管杂志,2017,22(02):121-125.
[2] 韩大兴,王芳芳,周宇廷,等.慢性心力衰竭患者血清肌钙蛋白Ⅰ脑钠肽与纽约心脏病协会心功能分级及心脏超声参数相关性分析[J].山西医药杂志,2017,46(9):1022-1024.
[3] Chen X,Chen C,Fan S,et al.Omega-3 polyunsaturated fatty acid attenuates the inflammatory response by modulating microglia polarization through SIRT1-mediated deacetylation of the HMGB1/NF-κB pathway following experimental traumatic brain injury[J].J Neuroinflammation,2018,15(1):116.
[4] 中国中西医结合学会,中国医师协会中西医结合医师分会.慢性心力衰竭中西医结合诊疗专家共识[J].中国中西医结合杂志,2016,36(2):133-141.
[5] 甄海旭.老年高血压合并慢性心力衰竭患者血清TGF-β1、CTGF水平变化及其与心功能的相关性分析[J].医学临床研究,2019,36(1):74-76.
[6] 邱伯雍.慢性心力衰竭流行病学及防治研究进展[J].中华实用诊断与治疗杂志,2017,31(6):619-621.
[7] Lee JH,Moon JH,Lee YJ,et al.SIRT1,a Class Ⅲ histone deacetylase,regulates LPS-induced inflammation in human keratinocytes and mediates the anti-inflammatory effects of hinokitiol[J].J Invest Dermatol,2017,137(6):1257-1266.
[8] 鄢晓丽,高电萨,龙梦云,等.慢性心力衰竭患者血清SIRT1水平变化及其对预后评估的价值[J].山东医药,2018,1102(28):65-68.
[9] 王韦,张政.辛伐他汀联合抗阻训练对慢性心力衰竭患者心功能及外周血单个核细胞内沉默信息调节因子2相关酶3和核转录因子-κB信号通路的影响[J].中国慢性病预防与控制,2019,27(2):97-101.
[10] 陈珏.利心冲剂调控Sirt1/PGC-1α蛋白干预心衰模型心肌能量代谢的机制[D].南京中医药大学,2017.