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| Relationship of Treg, Th17 Cells and serum FGF23 with Carotid Atherosclerosis in Patients with MHD |
| PAN Yan-zi, ZHANG Juan |
| Department of Nephrology, Baoji Hospital of Traditional Chinese Medicine 721001 |
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Abstract 【Objective】To investigate the relationship of peripheral blood regulatory T cells (Treg), helper T cell (Th17) and serum fibroblast growth factor-23 (FGF23) with carotid atherosclerosis in patients with maintenance hemodialysis (MHD) treatment. 【Methods】A total of 120 patients who underwent MHD received color Doppler ultrasonography (CDFI) to measure the intima-media thickness (IMT) of carotid artery. There were 52 cases belonging to the sclerotic group with IMT≥1.0 mm and 68 cases were in the non-sclerotic group. The levels of Treg, Th17 cells and serum FGF23 in the peripheral blood were compared between the two groups. The correlation between the above indicators and IMT was analyzed. 【Results】There were no significant differences in age, gender, primary disease composition, hyperlipidemia, smoking, and alcohol consumption between the sclerotic group and the non-sclerosis group (P>0.05). compared to the non-sclerotic group, patients in the sclerosis group had longer dialysis treatment (P<0.05). Levels of Th17 cells, serum FGF23, and carotid IMT of the peripheral blood in the sclerotic group were higher than those in the non-sclerotic group (P<0.05). While the Treg level in the sclerotic group was significantly lower than that in the non-sclerotic group (P<0.05). Pearson linear correlation analysis showed that the peripheral blood levels of Th17 cells and serum FGF23 in MHD patients were positive correction with IMT (P<0.05); while Treg value showed a significant negative correlation with IMT (P<0.05). 【Conclusion】Immunity imbalance and elevated serum FGF23 level in patients with MHD may be associated with carotid atherosclerosis.
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Received: 12 August 2019
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2020, Vol. 37 
