失代偿期乙型肝炎肝硬化患者血清PA、MMP-2、CYFRA21-1水平及意义

doi:10.3969/j.issn.1671-7171.2020.11.028

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Abstract 【Objective】To investigate the levels and significance of serum prealbumin (PA), matrix metalloproteinase-2 (MMP-2) and cytokeratin 19 fragment (CYFRA21-1) in patients with decompensated hepatitis B(HB) cirrhosis. 【Methods】Sixty-eight patients with chronic HB (chronic group), 50 patients with compensatory HB cirrhosis (compensatory group) and 42 patients with decompensated HB cirrhosis (decompensated group) were selected,and 60 healthy volunteers were selected as control group;serum PA, MMP-2 and CYFRA21-1 level were detected. 【Results】The levels of serum PA from low to high were the decompensated group, the bcompensatory group, the chronic group and the control group, and the differences were significant (P<0.05). MMP-2 and CYFRA21-1 from high to low were the decompensated group, the compensatory group, the chronic group and the control group, and there were significant differences among each group (P<0.05). In the decompensated group, serum PA was (37.22±9.94) mg/L, which was significantly lower than that of survival patients (P<0.05), while MMP-2 and CYFRA21-1 were (1.50±0.27) ng/L and (1.56±0.24) ng/mL, which were significantly higher than those of survival patients (P<0.05). The area under ROC curve for predicting death of patients with decompensated hepatitis B cirrhosis by serum PA, MMP-2 and CYFRA21-1 was 0.911, 0.736 and 0.686, respectively( All P<0.05). 【Conclusion】Serum PA is significantly decreased in patients with decompensated hepatitis B cirrhosis, while MMP-2 and CYFRA21-1 are significantly increased in patients with decompensated hepatitis B cirrhosis.The three methods have certain application value in predicting prognosis.

Key words： Hepatitis B/CO Liver Cirrhosis/ET Matrix Metalloproteinase 2/BL Prealbumin/BL Keratins/BL

Received: 12 August 2019

PACS:

R657.31

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	XIA Xiao-xiao
	SHI Dong-tao

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XIA Xiao-xiao,SHI Dong-tao. Levels and Significance of Serum PA, MMP-2, CYFRA21-1 in Patients with Decompensated Hepatitis B Cirrhosis[J]. JOURNAL OF CLINICAL RESEARCH, 2020, 37(11): 1691-1693.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2020.11.028 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2020/V37/I11/1691

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