中性粒细胞与淋巴细胞比值与老年心血管疾病患者全因死亡的相关性研究<sup>*</sup>

doi:10.3969/j.issn.1671-7171.2026.05.002

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Abstract 【Objective】 To investigate the relationship between neutrophil to lymphocyte ratio (NLR) and all-cause mortality in elderly patients with cardiovascular disease (CVD). 【Methods】 A total of 3206 elderly patients with CVD were included from the National Health and Nutrition Examination Survey of America from 1999 to 2018. The participants were divided into four groups according to the quartiles of NLR: Q1 (NLR<1.74), Q2 (1.74≤NLR< 2.37), Q3 (2.37≤NLR < 3.23), and Q4 (NLR≥3.23). The association between NLR and all-cause mortality was analyzed, and the predictive value of NLR for all-cause mortality was evaluated. 【Results】 The Kaplan-Meier survival analysis showed that the higher NLR level group had a lower survival rate. The Cox proportional hazards regression model showed that after adjusting for confounding factors, there is a significant positive association between elevated NLR levels and the risk of all-cause mortality. Compared with the lowest NLR level group Q1, the highest NLR level group Q4 had a 45% increased risk of all-cause mortality (P<0.05). Restricted cubic spline analysis showed a non-linear positive correlation between NLR and all-cause mortality risk (P<0.05). The time-dependent receiver operating characteristic (ROC) curve analysis showed that the area under the curve for predicting all-cause mortality in elderly CVD patients using NLR at 1, 3, 5, and 10 years were 0.649, 0.625, 0.617, and 0.597, respectively. 【Conclusion】 Elevated NLR levels are independently associated with increasing all-cause mortality in elderly patients with cardiovascular disease, which helps identify high-risk individuals in this population.

Key words： Neutrophils Lymphocytes Cardiovascular Diseases Aged Correlation of Data

Received: 28 November 2025

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R543

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2026.05.002 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2026/V43/I5/708

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