麻醉诱导前应用右美托咪定对老年妇科腹腔镜手术患者术后认知功能的影响

doi:10.3969/j.issn.1671-7171.2026.05.015

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Abstract 【Objective】 To investigate the effect of dexmedetomidine (Dex) administered before anesthesia induction on postoperative cognitive function in elderly patients undergoing gynecological laparoscopic surgery. 【Methods】 A total of 88 elderly patients scheduled for gynecological laparoscopic surgery were randomly divided into an observation group and a control group, with 44 patients in each group. Before anesthesia induction, the observation group received 0.5 μg/kg Dex, while the control group received an equal volume of normal saline. Perioperative indicators were compared between the two groups. Diastolic blood pressure (DBP), systolic blood pressure (SBP), heart rate (HR), norepinephrine (NE), and renin activity were measured before administration (T₀), 30 min after administration (T₁), 10 min before extubation (T₂), and 10 min after extubation (T₃). Mini-Mental State Examination (MMSE) scores, Visual Analogue Scale (VAS) scores, and the incidence of adverse reactions were recorded before and after surgery. 【Results】 There were no statistically significant differences between the two groups in operation time, anesthesia time, intraoperative blood loss, or fluid infusion volume (P>0.05). The awakening agitation score (RS) in the observation group was lower than that in the control group (P<0.05). Significant differences were observed in SBP, DBP, and HR at T₁, T₂, and T₃ between the two groups (P<0.05). NE and renin activity levels at T₂ and T₃ also showed significant differences between the two groups (P<0.05). VAS scores at postoperative day 3 were lower than those at postoperative day 1 in both groups (P<0.05), and the VAS scores in the control group were higher than those in the observation group (P<0.05). The postoperative MMSE score in the control group was lower than that before surgery of the control group and it was lower than that in the observation group after surgery (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】 Administration of Dex before anesthesia induction in elderly patients undergoing gynecological laparoscopic surgery can reduce the risk of postoperative cognitive dysfunction and postoperative adverse reactions, with good safety.

Key words： Laparoscopy Gynecologic Surgical Procedures Dexmedetomidine Anesthesia Cognition Aged

Received: 13 October 2024

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R713

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	GENG Fengxin
	LIU Yuanyuan
	LI Jifeng

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GENG Fengxin,LIU Yuanyuan,LI Jifeng. Effect of Dexmedetomidine Administered before Anesthesia Induction on Postoperative Cognitive Function in Elderly Patients Undergoing Gynecological Laparoscopic Surgery[J]. JOURNAL OF CLINICAL RESEARCH, 2026, 43(5): 758-761.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2026.05.015 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2026/V43/I5/758

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